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Identification of Antiglycative Compounds in Japanese Red Water Pepper (Red Leaf Variant of the Persicaria hydropiper Sprout).

Takabe W, Yamaguchi T, Hayashi H, Sugimura N, Yagi M, Yonei Y.

Molecules. 2018 Sep 11;23(9). pii: E2319. doi: 10.3390/molecules23092319.


Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death.

Takabe W, Urano Y, Vo DH, Shibuya K, Tanno M, Kitagishi H, Fujimoto T, Noguchi N.

J Lipid Res. 2016 Nov;57(11):2005-2014. Epub 2016 Sep 19.


Age-related diseases of the skin and anti-aging medicine.

Yonei Y, Ichihashi M, Takabe W.

Nihon Rinsho. 2016 Sep;74(9):1541-1547. Japanese.


Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.

Shibuya K, Watanabe T, Urano Y, Takabe W, Noguchi N, Kitagishi H.

Bioorg Med Chem. 2016 Jun 1;24(11):2559-66. doi: 10.1016/j.bmc.2016.04.024. Epub 2016 Apr 12.


New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death.

Noguchi N, Urano Y, Takabe W, Saito Y.

Free Radic Biol Med. 2015 Oct;87:366-72. doi: 10.1016/j.freeradbiomed.2015.06.036. Epub 2015 Jul 9. Review.


Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.

Morita M, Sekine A, Urano Y, Nishimura T, Takabe W, Arai H, Hamakubo T, Kodama T, Noguchi N.

J Biochem. 2015 Oct;158(4):331-8. doi: 10.1093/jb/mvv044. Epub 2015 May 21.


24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8.

Vo DK, Urano Y, Takabe W, Saito Y, Noguchi N.

Steroids. 2015 Jul;99(Pt B):230-7. doi: 10.1016/j.steroids.2015.02.007. Epub 2015 Feb 16.


Disturbed flow enhances inflammatory signaling and atherogenesis by increasing thioredoxin-1 level in endothelial cell nuclei.

Go YM, Son DJ, Park H, Orr M, Hao L, Takabe W, Kumar S, Kang DW, Kim CW, Jo H, Jones DP.

PLoS One. 2014 Sep 29;9(9):e108346. doi: 10.1371/journal.pone.0108346. eCollection 2014.


Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos.

Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2268-75. doi: 10.1161/ATVBAHA.114.303345. Epub 2014 Aug 21.


The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis.

Son DJ, Kumar S, Takabe W, Kim CW, Ni CW, Alberts-Grill N, Jang IH, Kim S, Kim W, Won Kang S, Baker AH, Woong Seo J, Ferrara KW, Jo H.

Nat Commun. 2013;4:3000. doi: 10.1038/ncomms4000.


Disturbed flow: p53 SUMOylation in the turnover of endothelial cells.

Takabe W, Alberts-Grill N, Jo H.

J Cell Biol. 2011 May 30;193(5):805-7. doi: 10.1083/jcb.201104140.


Anti-atherogenic effect of laminar shear stress via Nrf2 activation.

Takabe W, Warabi E, Noguchi N.

Antioxid Redox Signal. 2011 Sep 1;15(5):1415-26. doi: 10.1089/ars.2010.3433. Epub 2011 Apr 21. Review.


Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling.

Takabe W, Jen N, Ai L, Hamilton R, Wang S, Holmes K, Dharbandi F, Khalsa B, Bressler S, Barr ML, Li R, Hsiai TK.

Antioxid Redox Signal. 2011 Sep 1;15(5):1379-88. doi: 10.1089/ars.2010.3645. Epub 2011 Apr 14.


Electrocardiogram signals to assess zebrafish heart regeneration: implication of long QT intervals.

Yu F, Li R, Parks E, Takabe W, Hsiai TK.

Ann Biomed Eng. 2010 Jul;38(7):2346-57. doi: 10.1007/s10439-010-9993-6. Epub 2010 Mar 11.


Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis.

Takabe W, Li R, Ai L, Yu F, Berliner JA, Hsiai TK.

Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):436-41. doi: 10.1161/ATVBAHA.109.202135. Epub 2010 Feb 5.


Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD.

Li R, Beebe T, Cui J, Rouhanizadeh M, Ai L, Wang P, Gundersen M, Takabe W, Hsiai TK.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):406-12. doi: 10.1016/j.bbrc.2009.08.022. Epub 2009 Aug 8.


Optimization of intravascular shear stress assessment in vivo.

Ai L, Yu H, Takabe W, Paraboschi A, Yu F, Kim ES, Li R, Hsiai TK.

J Biomech. 2009 Jul 22;42(10):1429-37. doi: 10.1016/j.jbiomech.2009.04.021. Epub 2009 May 19.


Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation.

Li R, Ning Z, Cui J, Khalsa B, Ai L, Takabe W, Beebe T, Majumdar R, Sioutas C, Hsiai T.

Free Radic Biol Med. 2009 Mar 15;46(6):775-82. doi: 10.1016/j.freeradbiomed.2008.11.025. Epub 2008 Dec 11.


Monitoring oxidative stress in vascular endothelial cells in response to fluid shear stress: from biochemical analyses to micro- and nanotechnologies.

Rouhanizadeh M, Takabe W, Ai L, Yu H, Hsiai T.

Methods Enzymol. 2008;441:111-50. doi: 10.1016/S0076-6879(08)01207-X. Review.


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