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Items: 1 to 20 of 104


Targeting SOX2 Protein with Peptide Aptamers for Therapeutic Gains against Esophageal Squamous Cell Carcinoma.

Liu K, Xie F, Zhao T, Zhang R, Gao A, Chen Y, Li H, Zhang S, Xiao Z, Li J, Hong X, Shang L, Huang W, Wang J, El-Rifai W, Zaika A, Chen X, Que J, Lan X.

Mol Ther. 2020 Jan 15. pii: S1525-0016(20)30036-8. doi: 10.1016/j.ymthe.2020.01.012. [Epub ahead of print]


Claudin-1, A Double-Edged Sword in Cancer.

Bhat AA, Syed N, Therachiyil L, Nisar S, Hashem S, Macha MA, Yadav SK, Krishnankutty R, Muralitharan S, Al-Naemi H, Bagga P, Reddy R, Dhawan P, Akobeng A, Uddin S, Frenneaux MP, El-Rifai W, Haris M.

Int J Mol Sci. 2020 Jan 15;21(2). pii: E569. doi: 10.3390/ijms21020569. Review.


Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers.

Gomaa A, Peng D, Chen Z, Soutto M, Abouelezz K, Corvalan A, El-Rifai W.

Sci Rep. 2019 Nov 18;9(1):16970. doi: 10.1038/s41598-019-53174-6.


PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.

Wang S, Chen Z, Zhu S, Lu H, Peng D, Soutto M, Naz H, Peek R Jr, Xu H, Zaika A, Xu Z, El-Rifai W.

Redox Biol. 2020 Jan;28:101319. doi: 10.1016/j.redox.2019.101319. Epub 2019 Sep 5.


APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma.

Lu H, Bhat AA, Peng D, Chen Z, Zhu S, Hong J, Maacha S, Yan J, Robbins DJ, Washington MK, Belkhiri A, El-Rifai W.

Cancer Res. 2019 Sep 1;79(17):4426-4438. doi: 10.1158/0008-5472.CAN-19-0237. Epub 2019 Jul 15.


Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.

Soutto M, Chen Z, Bhat AA, Wang L, Zhu S, Gomaa A, Bates A, Bhat NS, Peng D, Belkhiri A, Piazuelo MB, Washington MK, Steven XC, Peek R Jr, El-Rifai W.

Nat Commun. 2019 Jul 10;10(1):3039. doi: 10.1038/s41467-019-11011-4.


Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells.

Zhu S, Soutto M, Chen Z, Blanca Piazuelo M, Kay Washington M, Belkhiri A, Zaika A, Peng D, El-Rifai W.

Oncogene. 2019 Jul;38(29):5805-5816. doi: 10.1038/s41388-019-0843-1. Epub 2019 Jun 24.


NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.

Peng D, Lu H, Zhu S, Zhou Z, Hu T, Chen Z, Zaika A, El-Rifai W.

Cancer Lett. 2019 Aug 28;458:46-55. doi: 10.1016/j.canlet.2019.05.031. Epub 2019 May 24.


Phase IB Study of Induction Chemotherapy With XELOX, Followed by Radiation Therapy, Carboplatin, and Everolimus in Patients With Locally Advanced Esophageal Cancer.

Saba NF, Force S, Staley C, Fernandez F, Willingham F, Pickens A, Cardona K, Chen Z, Goff L, Cardin D, Lambright E, Nesbitt J, Krasinskas A, Higgins K, Harvey RD, Owonikoko T, Ramalingam SS, Shin DM, Beitler JJ, El-Rayes BF, Salaria S, El-Rifai W, Landry J, Chakravarthy AB.

Am J Clin Oncol. 2019 Apr;42(4):331-336. doi: 10.1097/COC.0000000000000524.


Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage.

Zhou Z, Lu H, Zhu S, Gomaa A, Chen Z, Yan J, Washington K, El-Rifai W, Dang C, Peng D.

J Exp Clin Cancer Res. 2019 Jan 9;38(1):13. doi: 10.1186/s13046-018-1021-y.


Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis.

Chen Z, Li Z, Soutto M, Wang W, Piazuelo MB, Zhu S, Guo Y, Maturana MJ, Corvalan AH, Chen X, Xu Z, El-Rifai WM.

Gastroenterology. 2019 Mar;156(4):1127-1139.e8. doi: 10.1053/j.gastro.2018.11.052. Epub 2018 Nov 28.


Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.

Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W.

Gastroenterology. 2019 Feb;156(3):662-675.e7. doi: 10.1053/j.gastro.2018.10.030. Epub 2018 Oct 17.


Correction to: Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.

Goff LW, Azad NS, Stein S, Whisenant JG, Koyama T, Vaishampayan U, Hochster H, Connolly R, Weise A, LoRusso PM, Salaria SN, El-Rifai W, Berlin JD.

Invest New Drugs. 2018 Dec;36(6):1158. doi: 10.1007/s10637-018-0679-5.


Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.

Goff LW, Azad NS, Stein S, Whisenant JG, Koyama T, Vaishampayan U, Hochster H, Connolly R, Weise A, LoRusso PM, Salaria SN, El-Rifai W, Berlin JD.

Invest New Drugs. 2019 Apr;37(2):315-322. doi: 10.1007/s10637-018-0663-0. Epub 2018 Sep 6. Erratum in: Invest New Drugs. 2018 Oct 18;:.


TFF1 antagonizes TIMP-1 mediated proliferative functions in gastric cancer.

Omar OM, Soutto M, Bhat NS, Bhat AA, Lu H, Chen Z, El-Rifai W.

Mol Carcinog. 2018 Nov;57(11):1577-1587. doi: 10.1002/mc.22880. Epub 2018 Aug 14.


Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1.

Bhat AA, Lu H, Soutto M, Capobianco A, Rai P, Zaika A, El-Rifai W.

Oncogene. 2018 Nov;37(46):6011-6024. doi: 10.1038/s41388-018-0388-8. Epub 2018 Jul 10.


Helicobacter pylori-induced miR-135b-5p promotes cisplatin resistance in gastric cancer.

Shao L, Chen Z, Soutto M, Zhu S, Lu H, Romero-Gallo J, Peek R, Zhang S, El-Rifai W.

FASEB J. 2019 Jan;33(1):264-274. doi: 10.1096/fj.201701456RR. Epub 2018 Jul 9.


Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells.

Horvat A, Noto JM, Ramatchandirin B, Zaika E, Palrasu M, Wei J, Schneider BG, El-Rifai W, Peek RM Jr, Zaika AI.

Oncogene. 2018 Sep;37(37):5054-5065. doi: 10.1038/s41388-018-0343-8. Epub 2018 May 30.


Methylation of the HOXA10 Promoter Directs miR-196b-5p-Dependent Cell Proliferation and Invasion of Gastric Cancer Cells.

Shao L, Chen Z, Peng D, Soutto M, Zhu S, Bates A, Zhang S, El-Rifai W.

Mol Cancer Res. 2018 Apr;16(4):696-706. doi: 10.1158/1541-7786.MCR-17-0655. Epub 2018 Feb 16.


A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers.

Zhu S, Chen Z, Wang L, Peng D, Belkhiri A, Lockhart AC, El-Rifai W.

Clin Cancer Res. 2018 Apr 15;24(8):1905-1916. doi: 10.1158/1078-0432.CCR-17-1716. Epub 2018 Jan 31.

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