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Items: 1 to 20 of 144


Tunability of Biodegradable Poly(amine- co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications.

Kauffman AC, Piotrowski-Daspit AS, Nakazawa KH, Jiang Y, Datye A, Saltzman WM.

Biomacromolecules. 2018 Sep 10;19(9):3861-3873. doi: 10.1021/acs.biomac.8b00997. Epub 2018 Aug 28.


Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection.

Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8114-E8115. doi: 10.1073/pnas.1810136115. Epub 2018 Aug 10. No abstract available.


Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.

Lopez Sambrooks C, Baro M, Quijano A, Narayan A, Cui W, Greninger P, Egan R, Patel A, Benes CH, Saltzman WM, Contessa JN.

Cancer Res. 2018 Sep 1;78(17):5094-5106. doi: 10.1158/0008-5472.CAN-18-0505. Epub 2018 Jul 19.


Oligosaccharyltransferase inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity.

Baro M, Lopez Sambrooks C, Quijano A, Saltzman WM, Contessa JN.

Clin Cancer Res. 2018 Jul 2. pii: clincanres.0792.2018. doi: 10.1158/1078-0432.CCR-18-0792. [Epub ahead of print]


In utero nanoparticle delivery for site-specific genome editing.

Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM.

Nat Commun. 2018 Jun 26;9(1):2481. doi: 10.1038/s41467-018-04894-2.


Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors.

Chen EM, Quijano AR, Seo YE, Jackson C, Josowitz AD, Noorbakhsh S, Merlettini A, Sundaram RK, Focarete ML, Jiang Z, Bindra RS, Saltzman WM.

Biomaterials. 2018 Sep;178:193-203. doi: 10.1016/j.biomaterials.2018.06.024. Epub 2018 Jun 18.


Focus on Fundamentals: Achieving Effective Nanoparticle Targeting.

Tietjen GT, Bracaglia LG, Saltzman WM, Pober JS.

Trends Mol Med. 2018 Jul;24(7):598-606. doi: 10.1016/j.molmed.2018.05.003. Epub 2018 Jun 5. Review.


A "top-down" approach to actuate poly(amine-co-ester) terpolymers for potent and safe mRNA delivery.

Jiang Y, Gaudin A, Zhang J, Agarwal T, Song E, Kauffman AC, Tietjen GT, Wang Y, Jiang Z, Cheng CJ, Saltzman WM.

Biomaterials. 2018 Sep;176:122-130. doi: 10.1016/j.biomaterials.2018.05.043. Epub 2018 May 25.


Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing.

Ricciardi AS, Quijano E, Putman R, Saltzman WM, Glazer PM.

Molecules. 2018 Mar 11;23(3). pii: E632. doi: 10.3390/molecules23030632. Review.


Nanomaterials for convection-enhanced delivery of agents to treat brain tumors.

Seo YE, Bu T, Saltzman WM.

Curr Opin Biomed Eng. 2017 Dec;4:1-12. doi: 10.1016/j.cobme.2017.09.002. Epub 2017 Sep 22.


From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection.

Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E802-E811. doi: 10.1073/pnas.1717932115. Epub 2017 Dec 26. Erratum in: Proc Natl Acad Sci U S A. 2018 Mar 12;:.


Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities.

Quijano E, Bahal R, Ricciardi A, Saltzman WM, Glazer PM.

Yale J Biol Med. 2017 Dec 19;90(4):583-598. eCollection 2017 Dec. Review.


Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy.

Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM.

Mol Ther Nucleic Acids. 2017 Dec 15;9:111-119. doi: 10.1016/j.omtn.2017.09.001. Epub 2017 Sep 12.


Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys.

Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaam6764. doi: 10.1126/scitranslmed.aam6764.


Improved threshold selection for the determination of volume of distribution of nanoparticles administered by convection-enhanced delivery.

Chi DL, Song E, Gaudin A, Saltzman WM.

Comput Med Imaging Graph. 2017 Dec;62:34-40. doi: 10.1016/j.compmedimag.2017.08.001. Epub 2017 Aug 24.


Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir.

Mohideen M, Quijano E, Song E, Deng Y, Panse G, Zhang W, Clark MR, Saltzman WM.

Biomaterials. 2017 Nov;144:144-154. doi: 10.1016/j.biomaterials.2017.08.029. Epub 2017 Aug 15.


Multifunctional Poly(amine-co-ester-co-ortho ester) for Efficient and Safe Gene Delivery.

Zhang J, Cui J, Deng Y, Jiang Z, Saltzman WM.

ACS Biomater Sci Eng. 2016 Nov 14;2(11):2080-2089. doi: 10.1021/acsbiomaterials.6b00502. Epub 2016 Sep 26.


Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas.

King AR, Corso CD, Chen EM, Song E, Bongiorni P, Chen Z, Sundaram RK, Bindra RS, Saltzman WM.

Mol Cancer Ther. 2017 Aug;16(8):1456-1469. doi: 10.1158/1535-7163.MCT-16-0788. Epub 2017 May 31.


Surface chemistry governs cellular tropism of nanoparticles in the brain.

Song E, Gaudin A, King AR, Seo YE, Suh HW, Deng Y, Cui J, Tietjen GT, Huttner A, Saltzman WM.

Nat Commun. 2017 May 19;8:15322. doi: 10.1038/ncomms15322.


Quantitative microscopy-based measurements of circulating nanoparticle concentration using microliter blood volumes.

Tietjen GT, DiRito J, Pober JS, Saltzman WM.

Nanomedicine. 2017 Aug;13(6):1863-1867. doi: 10.1016/j.nano.2017.04.003. Epub 2017 Apr 13.


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