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Items: 1 to 20 of 37

1.

BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.

Rath EM, Cheng YY, Pinese M, Sarun KH, Hudson AL, Weir C, Wang YD, Håkansson AP, Howell VM, Liu GJ, Reid G, Knott RB, Duff AP, Church WB.

PLoS One. 2018 Aug 29;13(8):e0203003. doi: 10.1371/journal.pone.0203003. eCollection 2018.

2.

Fragment Screening of Human Kynurenine Aminotransferase-II.

Jayawickrama GS, Nematollahi A, Sun G, Church WB.

SLAS Discov. 2018 Jul;23(6):511-519. doi: 10.1177/2472555218764620. Epub 2018 Mar 14.

PMID:
29537924
3.

Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives.

Jayawickrama GS, Nematollahi A, Sun G, Gorrell MD, Church WB.

Sci Rep. 2017 Dec 14;7(1):17559. doi: 10.1038/s41598-017-17979-7.

4.

Neutron scattering shows a droplet of oleic acid at the center of the BAMLET complex.

Rath EM, Duff AP, Gilbert EP, Doherty G, Knott RB, Church WB.

Proteins. 2017 Jul;85(7):1371-1378. doi: 10.1002/prot.25298. Epub 2017 Apr 22.

PMID:
28380660
5.

Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human Group IIA phospholipase A2.

Kim RR, Malde AK, Nematollahi A, Scott KF, Church WB.

Proteins. 2017 May;85(5):827-842. doi: 10.1002/prot.25235. Epub 2017 Mar 16.

PMID:
28056488
6.

Host-Guest Complexes of Carboxylated Pillar[n]arenes With Drugs.

Wheate NJ, Dickson KA, Kim RR, Nematollahi A, Macquart RB, Kayser V, Yu G, Church WB, Marsh DJ.

J Pharm Sci. 2016 Dec;105(12):3615-3625. doi: 10.1016/j.xphs.2016.09.008. Epub 2016 Oct 21.

PMID:
27776769
7.

Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders.

Nematollahi A, Sun G, Jayawickrama GS, Hanrahan JR, Church WB.

Molecules. 2016 Jun 29;21(7). pii: E856. doi: 10.3390/molecules21070856.

8.

Kynurenine Aminotransferase Isozyme Inhibitors: A Review.

Nematollahi A, Sun G, Jayawickrama GS, Church WB.

Int J Mol Sci. 2016 Jun 15;17(6). pii: E946. doi: 10.3390/ijms17060946. Review.

9.

Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution.

Nematollahi A, Sun G, Harrop SJ, Hanrahan JR, Church WB.

Int J Mol Sci. 2016 Mar 25;17(4):446. doi: 10.3390/ijms17040446.

10.

Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.

Sun G, Nematollahi A, Nadvi NA, Kwan AH, Jeffries CM, Church WB.

Protein Expr Purif. 2016 May;121:41-5. doi: 10.1016/j.pep.2016.01.004. Epub 2016 Jan 8.

PMID:
26773745
11.

Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia.

Jayawickrama GS, Sadig RR, Sun G, Nematollahi A, Nadvi NA, Hanrahan JR, Gorrell MD, Church WB.

Curr Med Chem. 2015;22(24):2902-18. Review.

PMID:
26051411
12.

In silico evaluation of the influence of the translocon on partitioning of membrane segments.

Tessier D, Laroum S, Duval B, Rath EM, Church WB, Hao JK.

BMC Bioinformatics. 2014 May 21;15:156. doi: 10.1186/1471-2105-15-156.

13.

Small-angle X-ray scattering of BAMLET at pH 12: a complex of α-lactalbumin and oleic acid.

Rath EM, Duff AP, Håkansson AP, Knott RB, Church WB.

Proteins. 2014 Jul;82(7):1400-8. doi: 10.1002/prot.24508. Epub 2014 Jan 25.

PMID:
24408789
14.

Kink characterization and modeling in transmembrane protein structures.

Werner T, Church WB.

J Chem Inf Model. 2013 Nov 25;53(11):2926-36. doi: 10.1021/ci400236s. Epub 2013 Oct 29.

PMID:
24127817
15.

Phage display as a technology delivering on the promise of peptide drug discovery.

Hamzeh-Mivehroud M, Alizadeh AA, Morris MB, Church WB, Dastmalchi S.

Drug Discov Today. 2013 Dec;18(23-24):1144-57. doi: 10.1016/j.drudis.2013.09.001. Epub 2013 Sep 17. Review.

PMID:
24051398
16.

Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2.

Zhou F, Zheng J, Zhu L, Jodal A, Cui PH, Wong M, Gurney H, Church WB, Murray M.

AAPS J. 2013 Oct;15(4):1099-108. doi: 10.1208/s12248-013-9515-1. Epub 2013 Aug 6.

17.

A benchmark server using high resolution protein structure data, and benchmark results for membrane helix predictions.

Rath EM, Tessier D, Campbell AA, Lee HC, Werner T, Salam NK, Lee LK, Church WB.

BMC Bioinformatics. 2013 Mar 27;14:111. doi: 10.1186/1471-2105-14-111.

18.

The use of soluble protein structures in modeling helical proteins in a layered membrane.

Lee HW, Lee HC, Lee LK, Teber ET, Church WB.

J Biomol Struct Dyn. 2014;32(2):308-18. doi: 10.1080/07391102.2013.765808. Epub 2013 Mar 25.

PMID:
23527746
19.

Selective inhibition of human group IIA-secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes.

Lee LK, Bryant KJ, Bouveret R, Lei PW, Duff AP, Harrop SJ, Huang EP, Harvey RP, Gelb MH, Gray PP, Curmi PM, Cunningham AM, Church WB, Scott KF.

J Biol Chem. 2013 May 24;288(21):15269-79. doi: 10.1074/jbc.M112.397893. Epub 2013 Mar 12.

20.

Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I.

Akladios FN, Nadvi NA, Park J, Hanrahan JR, Kapoor V, Gorrell MD, Church WB.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1579-81. doi: 10.1016/j.bmcl.2011.12.138. Epub 2012 Jan 10.

PMID:
22281190

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