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Items: 1 to 20 of 171


Impact of p53 function on the sulfotransferase-mediated bioactivation of the alkylated polycyclic aromatic hydrocarbon 1-hydroxymethylpyrene in vitro.

Wohak LE, Monien B, Phillips DH, Arlt VM.

Environ Mol Mutagen. 2019 May 18. doi: 10.1002/em.22299. [Epub ahead of print]


Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid.

Jelaković B, Dika Ž, Arlt VM, Stiborova M, Pavlović NM, Nikolić J, Colet JM, Vanherweghem JL, Nortier JL.

Semin Nephrol. 2019 May;39(3):284-296. doi: 10.1016/j.semnephrol.2019.02.007. Review.


A Compendium of Mutational Signatures of Environmental Agents.

Kucab JE, Zou X, Morganella S, Joel M, Nanda AS, Nagy E, Gomez C, Degasperi A, Harris R, Jackson SP, Arlt VM, Phillips DH, Nik-Zainal S.

Cell. 2019 May 2;177(4):821-836.e16. doi: 10.1016/j.cell.2019.03.001. Epub 2019 Apr 11.


Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.

Indra R, Černá T, Heger Z, Hraběta J, Wilhelm M, Dostálová S, Lengálová A, Martínková M, Adam V, Eckschlager T, Schmeiser HH, Arlt VM, Stiborová M.

Toxicology. 2019 May 1;419:40-54. doi: 10.1016/j.tox.2019.03.009. Epub 2019 Mar 23.


Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.

Kolarik M, Indra R, Adam V, Heger Z, Kopeckova K, Arlt VM, Stiborova M.

Neuro Endocrinol Lett. 2019 Feb;39(7):515-524.


Co-exposure to polystyrene plastic beads and polycyclic aromatic hydrocarbon contaminants in fish gill (RTgill-W1) and intestinal (RTgutGC) epithelial cells derived from rainbow trout (Oncorhynchus mykiss).

Bussolaro D, Wright SL, Schnell S, Schirmer K, Bury NR, Arlt VM.

Environ Pollut. 2019 May;248:706-714. doi: 10.1016/j.envpol.2019.02.066. Epub 2019 Feb 22.


Determination of genomic N3-methylthymidine in human cancer cells treated with nitrosamines using capillary electrophoresis with laser-induced fluorescence.

Krais AM, Kliem C, Arlt VM, Schmeiser HH.

Electrophoresis. 2019 Jun;40(11):1535-1539. doi: 10.1002/elps.201800495. Epub 2019 Feb 27.


Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.

Reed L, Indra R, Mrizova I, Moserova M, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM.

Toxicol Appl Pharmacol. 2019 Mar 1;366:64-74. doi: 10.1016/j.taap.2019.01.020. Epub 2019 Jan 25.


Bulky DNA adducts, microRNA profiles, and lipid biomarkers in Norwegian tunnel finishing workers occupationally exposed to diesel exhaust.

Rynning I, Arlt VM, Vrbova K, Neča J, Rossner P Jr, Klema J, Ulvestad B, Petersen E, Skare Ø, Haugen A, Phillips DH, Machala M, Topinka J, Mollerup S.

Occup Environ Med. 2019 Jan;76(1):10-16. doi: 10.1136/oemed-2018-105445. Epub 2018 Nov 13.


Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone.

Murray JR, Mesaros CA, Arlt VM, Seidel A, Blair IA, Penning TM.

Chem Res Toxicol. 2018 Nov 19;31(11):1277-1288. doi: 10.1021/acs.chemrestox.8b00250. Epub 2018 Nov 8.


Hepatic DNA damage in harbour porpoises (Phocoena phocoena) stranded along the English and Welsh coastlines.

Acevedo-Whitehouse K, Cole KJ, Phillips DH, Jepson PD, Deaville R, Arlt VM.

Environ Mol Mutagen. 2018 Aug;59(7):613-624. doi: 10.1002/em.22205. Epub 2018 Jul 3.


The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo-in vitro paradox.

Reed L, Arlt VM, Phillips DH.

Carcinogenesis. 2018 Jul 3;39(7):851-859. doi: 10.1093/carcin/bgy058. Review.


Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats.

Stiborová M, Dračínská H, Bořek-Dohalská L, Klusoňová Z, Holecová J, Martínková M, Schmeiser HH, Arlt VM.

Toxicology. 2018 May 1;400-401:48-56. doi: 10.1016/j.tox.2018.04.001. Epub 2018 Apr 9.


Erratum to "Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53" [Toxicol. Appl. Pharmacol. 232(1) (2008) 86-98].

Simões ML, Hockley SL, Schwerdtle T, da Costa GG, Schmeiser HH, Phillips DH, Arlt VM.

Toxicol Appl Pharmacol. 2018 Apr 1;344:75. doi: 10.1016/j.taap.2018.02.010. Epub 2018 Feb 20. No abstract available.


The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells.

Willis AJ, Indra R, Wohak LE, Sozeri O, Feser K, Mrizova I, Phillips DH, Stiborova M, Arlt VM.

Toxicology. 2018 Apr 1;398-399:1-12. doi: 10.1016/j.tox.2018.02.006. Epub 2018 Feb 19.


Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells.

Jarvis IWH, Enlo-Scott Z, Nagy E, Mudway IS, Tetley TD, Arlt VM, Phillips DH.

Environ Mol Mutagen. 2018 May;59(4):290-301. doi: 10.1002/em.22166. Epub 2018 Jan 25.


Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice.

Reed L, Mrizova I, Barta F, Indra R, Moserova M, Kopka K, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM.

Arch Toxicol. 2018 Apr;92(4):1625-1638. doi: 10.1007/s00204-018-2162-7. Epub 2018 Jan 24.


Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.

Baker SC, Arlt VM, Indra R, Joel M, Stiborová M, Eardley I, Ahmad N, Otto W, Burger M, Rubenwolf P, Phillips DH, Southgate J.

Mol Carcinog. 2018 May;57(5):606-618. doi: 10.1002/mc.22784. Epub 2018 Feb 1.


The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells.

Cerna T, Hrabeta J, Eckschlager T, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Int J Mol Sci. 2018 Jan 5;19(1). pii: E164. doi: 10.3390/ijms19010164.

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