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Items: 16


Hypoxia Modulates Effects of Fatty Acids on NES2Y Human Pancreatic β-cells.

Šrámek J, Němcová-Fürstová V, Polák J, Kovář J.

Int J Mol Sci. 2019 Jul 12;20(14). pii: E3441. doi: 10.3390/ijms20143441.


Stearate-Induced Apoptosis in Human Pancreatic β-Cells is Associated with Changes in Membrane Protein Expression and These Changes are Inhibited by Oleate.

Němcová-Fürstová V, Balušíková K, Halada P, Pavlíková N, Šrámek J, Kovář J.

Proteomics Clin Appl. 2019 Jul;13(4):e1800104. doi: 10.1002/prca.201800104. Epub 2019 Jan 31.


Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.

Jelínek M, Balušíková K, Daniel P, Němcová-Fürstová V, Kirubakaran P, Jaček M, Wei L, Wang X, Vondrášek J, Ojima I, Kovář J.

Toxicol Appl Pharmacol. 2018 May 15;347:79-91. doi: 10.1016/j.taap.2018.04.002. Epub 2018 Apr 4.


Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic β-Cells Is Inhibited by Unsaturated Oleic Acid.

Šrámek J, Němcová-Fürstová V, Pavlíková N, Kovář J.

Int J Mol Sci. 2017 Nov 2;18(11). pii: E2313. doi: 10.3390/ijms18112313.


Genetic and functional analyses do not explain the association of high PRC1 expression with poor survival of breast carcinoma patients.

Brynychova V, Ehrlichova M, Hlavac V, Nemcova-Furstova V, Pecha V, Leva J, Trnkova M, Mrhalova M, Kodet R, Vrana D, Kovar J, Vaclavikova R, Gut I, Soucek P.

Biomed Pharmacother. 2016 Oct;83:857-864. doi: 10.1016/j.biopha.2016.07.047. Epub 2016 Aug 6.


Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters.

Němcová-Fürstová V, Kopperová D, Balušíková K, Ehrlichová M, Brynychová V, Václavíková R, Daniel P, Souček P, Kovář J.

Toxicol Appl Pharmacol. 2016 Nov 1;310:215-228. doi: 10.1016/j.taap.2016.09.020. Epub 2016 Sep 21.


Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells.

Šrámek J, Němcová-Fürstová V, Kovář J.

Int J Mol Sci. 2016 Sep 12;17(9). pii: E1400. doi: 10.3390/ijms17091400. Review.


Transcript expression and genetic variability analysis of caspases in breast carcinomas suggests CASP9 as the most interesting target.

Brynychova V, Hlavac V, Ehrlichova M, Vaclavikova R, Nemcova-Furstova V, Pecha V, Trnkova M, Mrhalova M, Kodet R, Vrana D, Gatek J, Bendova M, Vernerova Z, Kovar J, Soucek P.

Clin Chem Lab Med. 2017 Jan 1;55(1):111-122. doi: 10.1515/cclm-2016-0271.


p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells.

Šrámek J, Němcová-Fürstová V, Balušíková K, Daniel P, Jelínek M, James RF, Kovář J.

Int J Mol Sci. 2016 Feb 5;17(2):159. doi: 10.3390/ijms17020159.


Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness.

Jiroutková K, Krajčová A, Ziak J, Fric M, Waldauf P, Džupa V, Gojda J, Němcova-Fürstová V, Kovář J, Elkalaf M, Trnka J, Duška F.

Crit Care. 2015 Dec 24;19:448. doi: 10.1186/s13054-015-1160-x.


The role of individual caspases in cell death induction by taxanes in breast cancer cells.

Jelínek M, Balušíková K, Schmiedlová M, Němcová-Fürstová V, Šrámek J, Stančíková J, Zanardi I, Ojima I, Kovář J.

Cancer Cell Int. 2015 Feb 4;15(1):8. doi: 10.1186/s12935-015-0155-7. eCollection 2015.


Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.

Jelínek M, Balušíková K, Kopperová D, Nĕmcová-Fürstová V, Šrámek J, Fidlerová J, Zanardi I, Ojima I, Kovář J.

Cancer Cell Int. 2013 May 15;13(1):42. doi: 10.1186/1475-2867-13-42.


Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic β-cells.

Němcová-Fürstová V, Balušíková K, Srámek J, James RF, Kovář J.

Cell Physiol Biochem. 2013;31(2-3):277-89. doi: 10.1159/000343367. Epub 2013 Feb 28.


Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells.

Ehrlichová M, Ojima I, Chen J, Václavíková R, Němcová-Fürstová V, Vobořilová J, Simek P, Horský S, Souček P, Kovář J, Brabec M, Gut I.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Oct;385(10):1035-48. doi: 10.1007/s00210-012-0785-4. Epub 2012 Aug 2.


Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic β-cells: activation of caspases and ER stress induction.

Němcová-Fürstová V, James RF, Kovář J.

Cell Physiol Biochem. 2011;27(5):525-38. doi: 10.1159/000329954. Epub 2011 Jun 15.


Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells.

Vobořilová J, Němcová-Fürstová V, Neubauerová J, Ojima I, Zanardi I, Gut I, Kovář J.

Invest New Drugs. 2011 Jun;29(3):411-23. doi: 10.1007/s10637-009-9368-8. Epub 2009 Dec 16.

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