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Items: 1 to 20 of 71


Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.

Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakhsh S, Maalaoui H, Simard É, Titorenko VI.

Oncotarget. 2019 Oct 8;10(56):5780-5816. doi: 10.18632/oncotarget.27209. eCollection 2019 Oct 8.


Aging and Age-related Disorders: From Molecular Mechanisms to Therapies.

Titorenko VI.

Int J Mol Sci. 2019 Jul 3;20(13). pii: E3280. doi: 10.3390/ijms20133280.


Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla.

Dakik P, Medkour Y, Mohammad K, Titorenko VI.

Front Physiol. 2019 Apr 18;10:461. doi: 10.3389/fphys.2019.00461. eCollection 2019. Review.


Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI.

Int J Mol Sci. 2019 May 1;20(9). pii: E2158. doi: 10.3390/ijms20092158. Review.


Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.

Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI.

Oncotarget. 2019 Jan 8;10(3):313-338. doi: 10.18632/oncotarget.26553. eCollection 2019 Jan 8.


Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.

Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI.

Oncotarget. 2018 Oct 9;9(79):34945-34971. doi: 10.18632/oncotarget.26188. eCollection 2018 Oct 9.


Molecular and Cellular Mechanisms of Aging and Age-related Disorders.

Titorenko VI.

Int J Mol Sci. 2018 Jul 14;19(7). pii: E2049. doi: 10.3390/ijms19072049. No abstract available.


Yeast chronological aging is linked to cell cycle regulation.

Mohammad K, Titorenko VI.

Cell Cycle. 2018;17(9):1035-1036. doi: 10.1080/15384101.2018.1478670. Epub 2018 Jul 5. No abstract available.


Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.

Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI.

Oncotarget. 2018 Mar 5;9(22):16163-16184. doi: 10.18632/oncotarget.24604. eCollection 2018 Mar 23.


Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI.

Oxid Med Cell Longev. 2018 Jan 31;2018:3074769. doi: 10.1155/2018/3074769. eCollection 2018. Review.


Some Metabolites Act as Second Messengers in Yeast Chronological Aging.

Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI.

Int J Mol Sci. 2018 Mar 15;19(3). pii: E860. doi: 10.3390/ijms19030860. Review.


Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.

Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofigari-Esfahani N, Rosanelli L, Titorenko VI.

Oncotarget. 2017 Sep 1;8(41):69328-69350. doi: 10.18632/oncotarget.20614. eCollection 2017 Sep 19.


Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae.

Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI.

Front Biosci (Landmark Ed). 2018 Jan 1;23:1166-1194. Review.


Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT.

Cell Signal. 2017 Dec;40:172-182. doi: 10.1016/j.cellsig.2017.09.006. Epub 2017 Sep 18.


Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging.

Medkour Y, Dakik P, McAuley M, Mohammad K, Mitrofanova D, Titorenko VI.

Oxid Med Cell Longev. 2017;2017:2916985. doi: 10.1155/2017/2916985. Epub 2017 May 16. Review.


Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast.

Leonov A, Arlia-Ciommo A, Bourque SD, Koupaki O, Kyryakov P, Dakik P, McAuley M, Medkour Y, Mohammad K, Di Maulo T, Titorenko VI.

Oncotarget. 2017 May 9;8(19):30672-30691. doi: 10.18632/oncotarget.16766.


A laboratory test of evolutionary aging theories.

Iouk T, Titorenko VI.

Aging (Albany NY). 2017 Mar 21;9(3):600-601. doi: 10.18632/aging.101215. No abstract available.


Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms.

Gomez-Perez A, Kyryakov P, Burstein MT, Asbah N, Noohi F, Iouk T, Titorenko VI.

Front Genet. 2016 Dec 6;7:216. doi: 10.3389/fgene.2016.00216. eCollection 2016.


Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells.

Gafar AA, Draz HM, Goldberg AA, Bashandy MA, Bakry S, Khalifa MA, AbuShair W, Titorenko VI, Sanderson JT.

PeerJ. 2016 Nov 15;4:e2445. eCollection 2016.


Empirical verification of evolutionary theories of aging.

Kyryakov P, Gomez-Perez A, Glebov A, Asbah N, Bruno L, Meunier C, Iouk T, Titorenko VI.

Aging (Albany NY). 2016 Oct 25;8(10):2568-2589. doi: 10.18632/aging.101090.

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