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Items: 1 to 20 of 121

1.

A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.

Andrisano V, Naldi M, De Simone A, Bartolini M.

Expert Opin Ther Pat. 2018 Jun;28(6):455-465. doi: 10.1080/13543776.2018.1476494. Review.

PMID:
29757691
2.

Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors.

Hulcová D, Breiterová K, Siatka T, Klímová K, Davani L, Šafratová M, Hošťálková A, De Simone A, Andrisano V, Cahlíková L.

Molecules. 2018 Mar 21;23(4). pii: E719. doi: 10.3390/molecules23040719.

3.

The Role of Chromatography in Alzheimer's Disease Drug Discovery.

Fiori J, De Simone A, Naldi M, Andrisano V.

Adv Chromatogr. 2017;53:75-107. Review. No abstract available.

PMID:
29461692
4.

New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.

Pandolfi F, De Vita D, Bortolami M, Coluccia A, Di Santo R, Costi R, Andrisano V, Alabiso F, Bergamini C, Fato R, Bartolini M, Scipione L.

Eur J Med Chem. 2017 Dec 1;141:197-210. doi: 10.1016/j.ejmech.2017.09.022. Epub 2017 Sep 18.

PMID:
29031067
5.

Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.

De Simone A, Bartolini M, Baschieri A, Apperley KYP, Chen HH, Guardigni M, Montanari S, Kobrlova T, Soukup O, Valgimigli L, Andrisano V, Keillor JW, Basso M, Milelli A.

Eur J Med Chem. 2017 Oct 20;139:378-389. doi: 10.1016/j.ejmech.2017.07.058. Epub 2017 Jul 25.

PMID:
28810189
6.

Preface.

Andrisano V, Bartolini M, Tedesco D, Wainer IW.

J Pharm Biomed Anal. 2017 Sep 10;144:vi. doi: 10.1016/S0731-7085(17)31895-2. No abstract available.

PMID:
28800955
7.

Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.

Simoni E, Bartolini M, Abu IF, Blockley A, Gotti C, Bottegoni G, Caporaso R, Bergamini C, Andrisano V, Cavalli A, Mellor IR, Minarini A, Rosini M.

Future Med Chem. 2017 Jun;9(10):953-963. doi: 10.4155/fmc-2017-0039. Epub 2017 Jun 20.

PMID:
28632446
8.

Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.

Pérez-Areales FJ, Betari N, Viayna A, Pont C, Espargaró A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Pérez B, Sabate R, Lamuela-Raventós RM, Andrisano V, Luque FJ, Muñoz-Torrero D.

Future Med Chem. 2017 Jun;9(10):965-981. doi: 10.4155/fmc-2017-0049. Epub 2017 Jun 20.

PMID:
28632395
9.

Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development§.

Milelli A, De Simone A, Ticchi N, Chen HH, Betari N, Andrisano V, Tumiatti V.

Curr Med Chem. 2017;24(32):3522-3546. doi: 10.2174/0929867324666170309123920. Review.

PMID:
28294041
10.

Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors.

De Simone A, Fiori J, Naldi M, D'Urzo A, Tumiatti V, Milelli A, Andrisano V.

J Pharm Biomed Anal. 2017 Sep 10;144:159-166. doi: 10.1016/j.jpba.2017.02.036. Epub 2017 Feb 27.

PMID:
28268049
11.

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.

Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M.

ACS Med Chem Lett. 2016 Sep 26;7(12):1145-1150. eCollection 2016 Dec 8.

12.

Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease.

Seidl C, de Moraes Santos CA, De Simone A, Bartolini M, Weffort-Santos AM, Andrisano V.

Curr Alzheimer Res. 2017;14(3):317-326. doi: 10.2174/1567205013666161026150455.

PMID:
27784218
13.

Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.

Montanari S, Scalvini L, Bartolini M, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V, Rivara S, Mor M, Bisi A, Rampa A.

J Med Chem. 2016 Jul 14;59(13):6387-406. doi: 10.1021/acs.jmedchem.6b00609. Epub 2016 Jun 28.

PMID:
27309570
14.

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy.

Boulebd H, Ismaili L, Bartolini M, Bouraiou A, Andrisano V, Martin H, Bonet A, Moraleda I, Iriepa I, Chioua M, Belfaitah A, Marco-Contelles J.

Molecules. 2016 Mar 24;21(4):400. doi: 10.3390/molecules21040400.

15.

Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach.

D'Urzo A, Boichenko AP, van den Bosch T, Hermans J, Dekker F, Andrisano V, Bischoff R.

Anal Bioanal Chem. 2016 May;408(13):3547-53. doi: 10.1007/s00216-016-9431-1. Epub 2016 Mar 11.

16.

Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD).

D'Urzo A, De Simone A, Fiori J, Naldi M, Milelli A, Andrisano V.

J Pharm Biomed Anal. 2016 May 30;124:104-111. doi: 10.1016/j.jpba.2016.02.029. Epub 2016 Feb 23.

PMID:
26942334
17.

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease.

Prati F, Bergamini C, Fato R, Soukup O, Korabecny J, Andrisano V, Bartolini M, Bolognesi ML.

ChemMedChem. 2016 Jun 20;11(12):1284-95. doi: 10.1002/cmdc.201600014. Epub 2016 Feb 16.

PMID:
26880501
18.

Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets.

Chlebek J, De Simone A, Hošťálková A, Opletal L, Pérez C, Pérez DI, Havlíková L, Cahlíková L, Andrisano V.

Fitoterapia. 2016 Mar;109:241-7. doi: 10.1016/j.fitote.2016.01.008. Epub 2016 Jan 11.

PMID:
26779945
19.

Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.

Lemes LFN, de Andrade Ramos G, de Oliveira AS, da Silva FMR, de Castro Couto G, da Silva Boni M, Guimarães MJR, Souza INO, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korábečný J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LAS.

Eur J Med Chem. 2016 Jan 27;108:687-700. doi: 10.1016/j.ejmech.2015.12.024. Epub 2015 Dec 17.

PMID:
26735910
20.

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors.

Di Martino RM, De Simone A, Andrisano V, Bisignano P, Bisi A, Gobbi S, Rampa A, Fato R, Bergamini C, Perez DI, Martinez A, Bottegoni G, Cavalli A, Belluti F.

J Med Chem. 2016 Jan 28;59(2):531-44. doi: 10.1021/acs.jmedchem.5b00894. Epub 2016 Jan 7.

PMID:
26696252

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