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Items: 1 to 20 of 69


Cryptotanshinone (Dsh-003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells.

Chang JH, Lin CH, Shibu MA, Chou YC, Liu JY, Chou YH, Shen CY, Yeh YL, Viswanadha VP, Huang CY.

Environ Toxicol. 2018 Sep 12. doi: 10.1002/tox.22633. [Epub ahead of print]


Inhibition of ERK-Drp1 signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure.

Huang CY, Lai CH, Kuo CH, Chiang SF, Pai PY, Lin JY, Chang CF, Viswanadha VP, Kuo WW, Huang CY.

J Mol Cell Cardiol. 2018 Sep;122:58-68. doi: 10.1016/j.yjmcc.2018.08.006. Epub 2018 Aug 9.


Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice.

Dumeus S, Shibu MA, Lin WT, Wang MF, Lai CH, Shen CY, Lin YM, Viswanadha VP, Kuo WW, Huang CY.

Cell Physiol Biochem. 2018;48(5):1942-1952. doi: 10.1159/000492518. Epub 2018 Aug 9.


Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats.

Chiang JT, Badrealam KF, Shibu MA, Kuo CH, Huang CY, Chen BC, Lin YM, Viswanadha VP, Kuo WW, Huang CY.

Environ Toxicol. 2018 Jul 4. doi: 10.1002/tox.22589. [Epub ahead of print]


ERβ targets ZAK and attenuates cellular hypertrophy via SUMO-1 modification in H9c2 cells.

Pai P, Shibu MA, Chang RL, Yang JJ, Su CC, Lai CH, Liao HE, Viswanadha VP, Kuo WW, Huang CY.

J Cell Biochem. 2018 Jun 22. doi: 10.1002/jcb.27199. [Epub ahead of print]


Anti-Apoptosis and Anti-Fibrosis Effects of Eriobotrya Japonica in Spontaneously Hypertensive Rat Hearts.

Chiang JT, Badrealam KF, Shibu MA, Cheng SF, Shen CY, Chang CF, Lin YM, Viswanadha VP, Liao SC, Huang CY.

Int J Mol Sci. 2018 May 31;19(6). pii: E1638. doi: 10.3390/ijms19061638.


17β-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy.

Fang HY, Hung MY, Lin YM, Pandey S, Chang CC, Lin KH, Shen CY, Viswanadha VP, Kuo WW, Huang CY.

PLoS One. 2018 May 3;13(5):e0196569. doi: 10.1371/journal.pone.0196569. eCollection 2018.


GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway.

Chen BC, Hung MY, Wang HF, Yeh LJ, Pandey S, Chen RJ, Chang RL, Viswanadha VP, Lin KH, Huang CY.

Environ Toxicol. 2018 Jul;33(7):789-797. doi: 10.1002/tox.22565. Epub 2018 Apr 30.


Estrogen and/or Estrogen Receptor α Inhibits BNIP3-Induced Apoptosis and Autophagy in H9c2 Cardiomyoblast Cells.

Chen BC, Weng YJ, Shibu MA, Han CK, Chen YS, Shen CY, Lin YM, Viswanadha VP, Liang HY, Huang CY.

Int J Mol Sci. 2018 Apr 26;19(5). pii: E1298. doi: 10.3390/ijms19051298.


Overexpression of ZAKβ in human osteosarcoma cells enhances ZAKα expression, resulting in a synergistic apoptotic effect.

Fu CY, Tseng YS, Chen MC, Hsu HH, Yang JJ, Tu CC, Lin YM, Viswanadha VP, Ding K, Kuo WW, Huang CY.

Cell Biochem Funct. 2018 Jun;36(4):176-182. doi: 10.1002/cbf.3329. Epub 2018 Apr 13.


Lupeol alters ER stress-signaling pathway by downregulating ABCG2 expression to induce Oxaliplatin-resistant LoVo colorectal cancer cell apoptosis.

Chen MC, Hsu HH, Chu YY, Cheng SF, Shen CY, Lin YJ, Chen RJ, Viswanadha VP, Lin YM, Huang CY.

Environ Toxicol. 2018 May;33(5):587-593. doi: 10.1002/tox.22544. Epub 2018 Feb 13.


Elevated Phosphate Levels Trigger Autophagy-Mediated Cellular Apoptosis in H9c2 Cardiomyoblasts.

Liu YL, Lin KH, Tamilselvi S, Chen WK, Shen CY, Chen RJ, Day CH, Wu HC, Viswanadha VP, Huang CY.

Cardiorenal Med. 2017 Dec;8(1):31-40. doi: 10.1159/000479010. Epub 2017 Sep 30.


E4BP4 inhibits AngII-induced apoptosis in H9c2 cardiomyoblasts by activating the PI3K-Akt pathway and promoting calcium uptake.

Chen BC, Shibu MA, Kuo CH, Shen CY, Chang-Lee SN, Lai CH, Chen RJ, Yao CH, Viswanadha VP, Liu JS, Chen WK, Huang CY.

Exp Cell Res. 2018 Feb 15;363(2):227-234. doi: 10.1016/j.yexcr.2018.01.012. Epub 2018 Jan 10.


Oxaliplatin resistance in colorectal cancer cells is mediated via activation of ABCG2 to alleviate ER stress induced apoptosis.

Hsu HH, Chen MC, Baskaran R, Lin YM, Day CH, Lin YJ, Tu CC, Vijaya Padma V, Kuo WW, Huang CY.

J Cell Physiol. 2018 Jul;233(7):5458-5467. doi: 10.1002/jcp.26406. Epub 2018 Jan 23.


Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p-JNK mediated hypertrophy and enhancing P-IGF1R, p-akt, and p-Badser136 activity and by fortifying NRF2 antioxidation system.

Shibu MA, Kuo CH, Chen BC, Ju DT, Chen RJ, Lai CH, Huang PJ, Viswanadha VP, Kuo WW, Huang CY.

Environ Toxicol. 2018 Feb;33(2):220-233. doi: 10.1002/tox.22510. Epub 2017 Nov 15.


Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts.

Feng CC, Pandey S, Lin CY, Shen CY, Chang RL, Chang TT, Chen RJ, Viswanadha VP, Lin YM, Huang CY.

Biomed Pharmacother. 2018 Jan;97:880-885. doi: 10.1016/j.biopha.2017.11.020. Epub 2017 Nov 7.


Doxorubicin induces ZAKα overexpression with a subsequent enhancement of apoptosis and attenuation of survivability in human osteosarcoma cells.

Fu CY, Tseng YS, Chen MC, Hsu HH, Yang JJ, Tu CC, Lin YM, Viswanadha VP, Kuo WW, Huang CY.

Environ Toxicol. 2018 Feb;33(2):191-197. doi: 10.1002/tox.22507. Epub 2017 Nov 6.


Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis.

Chen YF, Day CH, Lee NH, Chen YF, Yang JJ, Lin CH, Chen RJ, Rajendran P, Viswanadha VP, Huang CY.

Int J Med Sci. 2017 Sep 30;14(12):1284-1291. doi: 10.7150/ijms.20396. eCollection 2017.


The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice.

Lin KH, Chiu CH, Kuo WW, Ju DT, Shen CY, Chen RJ, Lin CC, Viswanadha VP, Liu JS, Huang RS, Huang CY.

Environ Toxicol. 2018 Jan;33(1):83-92. doi: 10.1002/tox.22498. Epub 2017 Oct 25.


Short-term hypoxia upregulated Mas receptor expression to repress the AT1 R signaling pathway and attenuate Ang II-induced cardiomyocyte apoptosis.

Chang RL, Chang CF, Ju DT, Ho TJ, Chang TT, Lin JW, Li JC, Cheng SM, Day CH, Viswanadha VP, Huang CY.

J Cell Biochem. 2018 Mar;119(3):2742-2749. doi: 10.1002/jcb.26440. Epub 2017 Nov 24.


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