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Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage.

Gómez GI, Velarde V, Sáez JC.

Int J Mol Sci. 2019 Sep 7;20(18). pii: E4408. doi: 10.3390/ijms20184408.


The 12-HHT/BLT2/NO Axis Is Associated to the Wound Healing and Skin Condition in Different Glycaemic States.

Leguina-Ruzzi A, Ortiz Diban R, Velarde V.

Med Sci (Basel). 2019 Apr 24;7(4). pii: E65. doi: 10.3390/medsci7040065.


The streptozotocin-high fat diet induced diabetic mouse model exhibits severe skin damage and alterations in local lipid mediators.

Leguina-Ruzzi A, Ortiz R, Velarde V.

Biomed J. 2018 Oct;41(5):328-332. doi: 10.1016/ Epub 2018 Nov 3.


Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function.

Sáez JC, Contreras-Duarte S, Gómez GI, Labra VC, Santibañez CA, Gajardo-Gómez R, Avendaño BC, Díaz EF, Montero TD, Velarde V, Orellana JA.

Front Immunol. 2018 Aug 15;9:1899. doi: 10.3389/fimmu.2018.01899. eCollection 2018.


Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition.

Krause BJ, Casanello P, Dias AC, Arias P, Velarde V, Arenas GA, Preite MD, Iturriaga R.

Front Physiol. 2018 Jul 24;9:901. doi: 10.3389/fphys.2018.00901. eCollection 2018.


Boldine Improves Kidney Damage in the Goldblatt 2K1C Model Avoiding the Increase in TGF-β.

Gómez GI, Velarde V.

Int J Mol Sci. 2018 Jun 25;19(7). pii: E1864. doi: 10.3390/ijms19071864.


Angiotensin II-Induced Mesangial Cell Damaged Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels.

Gómez GI, Fernández P, Velarde V, Sáez JC.

Int J Mol Sci. 2018 Mar 23;19(4). pii: E957. doi: 10.3390/ijms19040957.


Effects of ascorbic acid on spermatogenesis and sperm parameters in diabetic rats.

Aguirre-Arias MV, Velarde V, Moreno RD.

Cell Tissue Res. 2017 Nov;370(2):305-317. doi: 10.1007/s00441-017-2660-6. Epub 2017 Aug 2.


Increased RhoA/Rho-Kinase Activity and Markers of Endothelial Dysfunction in Young Adult Subjects with Metabolic Syndrome.

Leguina-Ruzzi A, Pereira J, Pereira-Flores K, Valderas JP, Mezzano D, Velarde V, Sáez CG.

Metab Syndr Relat Disord. 2015 Nov;13(9):373-80. doi: 10.1089/met.2015.0061.


Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet.

Hernández-Salinas R, Decap V, Leguina A, Cáceres P, Perez D, Urquiaga I, Iturriaga R, Velarde V.

Biol Res. 2015 Sep 30;48:53. doi: 10.1186/s40659-015-0045-4.


Boldine prevents renal alterations in diabetic rats.

Hernández-Salinas R, Vielma AZ, Arismendi MN, Boric MP, Sáez JC, Velarde V.

J Diabetes Res. 2013;2013:593672. doi: 10.1155/2013/593672. Epub 2013 Dec 12.


Basic fibroblast growth factor reduces functional and structural damage in chronic kidney disease.

Villanueva S, Contreras F, Tapia A, Carreño JE, Vergara C, Ewertz E, Cespedes C, Irarrazabal C, Sandoval M, Velarde V, Vio CP.

Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F430-41. doi: 10.1152/ajprenal.00720.2012. Epub 2013 Nov 27.


EPAC expression and function in cardiac fibroblasts and myofibroblasts.

Olmedo I, Muñoz C, Guzmán N, Catalán M, Vivar R, Ayala P, Humeres C, Aránguiz P, García L, Velarde V, Díaz-Araya G.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):414-22. doi: 10.1016/j.taap.2013.06.022. Epub 2013 Jul 8.


Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure.

Villanueva S, Escobar P, Jacubovsky I, Irarrázabal C, Carreño JE, Erpel JM, Céspedes C, González AA, Vio CP, Velarde V.

Biol Res. 2012;45(1):51-60. doi: 10.4067/S0716-97602012000100007.


Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast.

Catalán M, Smolic C, Contreras A, Ayala P, Olmedo I, Copaja M, Boza P, Vivar R, Avalos Y, Lavandero S, Velarde V, Díaz-Araya G.

Toxicol Appl Pharmacol. 2012 Jun 15;261(3):300-8. doi: 10.1016/j.taap.2012.04.013. Epub 2012 Apr 18.


Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels.

Orellana JA, Sáez PJ, Cortés-Campos C, Elizondo RJ, Shoji KF, Contreras-Duarte S, Figueroa V, Velarde V, Jiang JX, Nualart F, Sáez JC, García MA.

Glia. 2012 Jan;60(1):53-68. doi: 10.1002/glia.21246. Epub 2011 Oct 10.


Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions.

Orellana JA, Figueroa XF, Sánchez HA, Contreras-Duarte S, Velarde V, Sáez JC.

CNS Neurol Disord Drug Targets. 2011 May;10(3):404-14. Review.


Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels.

Orellana JA, Hernández DE, Ezan P, Velarde V, Bennett MV, Giaume C, Sáez JC.

Glia. 2010 Feb;58(3):329-43. doi: 10.1002/glia.20926.


Effect of tamoxifen and retinoic acid on bradykinin induced proliferation in MCF-7 cells.

Searovic P, Alonso M, Oses C, Pereira-Flores K, Velarde V, Saez CG.

J Cell Biochem. 2009 Feb 15;106(3):473-81. doi: 10.1002/jcb.22031.


Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration.

Orellana JA, Sáez PJ, Shoji KF, Schalper KA, Palacios-Prado N, Velarde V, Giaume C, Bennett MV, Sáez JC.

Antioxid Redox Signal. 2009 Feb;11(2):369-99. doi: 10.1089/ars.2008.2130. Review.

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