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Mechanisms of Calcium Leak from Cardiac Sarcoplasmic Reticulum Revealed by Statistical Mechanics.

Maltsev AV, Stern MD, Maltsev VA.

Biophys J. 2019 Jun 4;116(11):2212-2223. doi: 10.1016/j.bpj.2019.04.031. Epub 2019 May 3.


Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node.

Kim MS, Maltsev AV, Monfredi O, Maltseva LA, Wirth A, Florio MC, Tsutsui K, Riordon DR, Parsons SP, Tagirova S, Ziman BD, Stern MD, Lakatta EG, Maltsev VA.

Cell Calcium. 2018 Sep;74:168-179. doi: 10.1016/j.ceca.2018.07.002. Epub 2018 Jul 10.


A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.

Tsutsui K, Monfredi OJ, Sirenko-Tagirova SG, Maltseva LA, Bychkov R, Kim MS, Ziman BD, Tarasov KV, Tarasova YS, Zhang J, Wang M, Maltsev AV, Brennan JA, Efimov IR, Stern MD, Maltsev VA, Lakatta EG.

Sci Signal. 2018 Jun 12;11(534). pii: eaap7608. doi: 10.1126/scisignal.aap7608.


Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.

Lyashkov AE, Behar J, Lakatta EG, Yaniv Y, Maltsev VA.

Biophys J. 2018 Apr 24;114(8):2024. doi: 10.1016/j.bpj.2018.03.024. No abstract available.


Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.

Lyashkov AE, Behar J, Lakatta EG, Yaniv Y, Maltsev VA.

Biophys J. 2018 Mar 13;114(5):1176-1189. doi: 10.1016/j.bpj.2017.12.043. Erratum in: Biophys J. 2018 Apr 24;114(8):2024.


Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells.

Sirenko SG, Yang D, Maltseva LA, Kim MS, Lakatta EG, Maltsev VA.

PLoS One. 2017 Sep 25;12(9):e0185222. doi: 10.1371/journal.pone.0185222. eCollection 2017.


Electrophysiological heterogeneity of pacemaker cells in the rabbit intercaval region, including the SA node: insights from recording multiple ion currents in each cell.

Monfredi O, Tsutsui K, Ziman B, Stern MD, Lakatta EG, Maltsev VA.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H403-H414. doi: 10.1152/ajpheart.00253.2016. Epub 2017 Sep 15.


Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells.

Maltsev AV, Parsons SP, Kim MS, Tsutsui K, Stern MD, Lakatta EG, Maltsev VA, Monfredi O.

PLoS One. 2017 Jul 6;12(7):e0179419. doi: 10.1371/journal.pone.0179419. eCollection 2017.


Clusters of calcium release channels harness the Ising phase transition to confine their elementary intracellular signals.

Maltsev AV, Maltsev VA, Stern MD.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7525-7530. doi: 10.1073/pnas.1701409114. Epub 2017 Jul 3.


Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells.

Sirenko SG, Maltsev VA, Yaniv Y, Bychkov R, Yaeger D, Vinogradova T, Spurgeon HA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H251-67. doi: 10.1152/ajpheart.00667.2015. Epub 2016 May 20.


Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.

Mishra S, Reznikov V, Maltsev VA, Undrovinas NA, Sabbah HN, Undrovinas A.

J Physiol. 2015 Mar 15;593(6):1409-27. doi: 10.1113/jphysiol.2014.278259. Epub 2014 Nov 17.


Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.


From two competing oscillators to one coupled-clock pacemaker cell system.

Yaniv Y, Lakatta EG, Maltsev VA.

Front Physiol. 2015 Feb 13;6:28. doi: 10.3389/fphys.2015.00028. eCollection 2015. Review.


Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate.

Monfredi O, Lyashkov AE, Johnsen AB, Inada S, Schneider H, Wang R, Nirmalan M, Wisloff U, Maltsev VA, Lakatta EG, Zhang H, Boyett MR.

Hypertension. 2014 Dec;64(6):1334-43. doi: 10.1161/HYPERTENSIONAHA.114.03782. Epub 2014 Sep 15.


Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.

Stern MD, Maltseva LA, Juhaszova M, Sollott SJ, Lakatta EG, Maltsev VA.

J Gen Physiol. 2014 May;143(5):577-604. doi: 10.1085/jgp.201311123.


Modern perspectives on numerical modeling of cardiac pacemaker cell.

Maltsev VA, Yaniv Y, Maltsev AV, Stern MD, Lakatta EG.

J Pharmacol Sci. 2014;125(1):6-38. Epub 2014 Apr 19. Review.


Numerical Modeling Calcium and CaMKII Effects in the SA Node.

Yaniv Y, Maltsev VA.

Front Pharmacol. 2014 Apr 1;5:58. doi: 10.3389/fphar.2014.00058. eCollection 2014. Review.


Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design.

Sirenko S, Maltsev VA, Maltseva LA, Yang D, Lukyanenko Y, Vinogradova TM, Jones LR, Lakatta EG.

J Mol Cell Cardiol. 2014 Jan;66:106-15. doi: 10.1016/j.yjmcc.2013.11.011. Epub 2013 Nov 22.


RyR-NCX-SERCA local cross-talk ensures pacemaker cell function at rest and during the fight-or-flight reflex.

Maltsev AV, Yaniv Y, Stern MD, Lakatta EG, Maltsev VA.

Circ Res. 2013 Oct 25;113(10):e94-e100. doi: 10.1161/CIRCRESAHA.113.302465.

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