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Items: 1 to 20 of 47


Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents.

Pittalà V, Vanella L, Maria Platania CB, Salerno L, Raffaele M, Amata E, Marrazzo A, Floresta G, Romeo G, Greish K, Intagliata S, Bucolo C, Sorrenti V.

Future Med Chem. 2019 Jul;11(13):1523-1536. doi: 10.4155/fmc-2018-0448.


Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and Fibrosis In Vitro.

Raffaele M, Carota G, Sferrazzo G, Licari M, Barbagallo I, Sorrenti V, Signorelli SS, Vanella L.

Antioxidants (Basel). 2019 Aug 5;8(8). pii: E277. doi: 10.3390/antiox8080277.


Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death.

Raffaele M, Pittalà V, Zingales V, Barbagallo I, Salerno L, Li Volti G, Romeo G, Carota G, Sorrenti V, Vanella L.

Int J Mol Sci. 2019 May 27;20(10). pii: E2593. doi: 10.3390/ijms20102593.


Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats.

Sorrenti V, Raffaele M, Vanella L, Acquaviva R, Salerno L, Pittalà V, Intagliata S, Di Giacomo C.

Int J Mol Sci. 2019 May 17;20(10). pii: E2441. doi: 10.3390/ijms20102441.


Beneficial Effects of Pomegranate Peel Extract and Probiotics on Pre-adipocyte Differentiation.

Sorrenti V, Randazzo CL, Caggia C, Ballistreri G, Romeo FV, Fabroni S, Timpanaro N, Raffaele M, Vanella L.

Front Microbiol. 2019 Apr 3;10:660. doi: 10.3389/fmicb.2019.00660. eCollection 2019.


N-Acetylcysteine (NAC) Ameliorates Lipid-Related Metabolic Dysfunction in Bone Marrow Stromal Cells-Derived Adipocytes.

Raffaele M, Barbagallo I, Licari M, Carota G, Sferrazzo G, Spampinato M, Sorrenti V, Vanella L.

Evid Based Complement Alternat Med. 2018 Oct 17;2018:5310961. doi: 10.1155/2018/5310961. eCollection 2018.


Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines.

Sorrenti V, Pittalà V, Romeo G, Amata E, Dichiara M, Marrazzo A, Turnaturi R, Prezzavento O, Barbagallo I, Vanella L, Rescifina A, Floresta G, Tibullo D, Di Raimondo F, Intagliata S, Salerno L.

Eur J Med Chem. 2018 Oct 5;158:937-950. doi: 10.1016/j.ejmech.2018.09.048. Epub 2018 Sep 17.


Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis.

Floresta G, Pittalà V, Sorrenti V, Romeo G, Salerno L, Rescifina A.

Bioorg Chem. 2018 Dec;81:334-339. doi: 10.1016/j.bioorg.2018.08.023. Epub 2018 Aug 27.


Heme Oxygenase Inhibition Sensitizes Neuroblastoma Cells to Carfilzomib.

Barbagallo I, Giallongo C, Volti GL, Distefano A, Camiolo G, Raffaele M, Salerno L, Pittalà V, Sorrenti V, Avola R, Di Rosa M, Vanella L, Di Raimondo F, Tibullo D.

Mol Neurobiol. 2019 Feb;56(2):1451-1460. doi: 10.1007/s12035-018-1133-6. Epub 2018 Jun 10.


Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation.

Greish KF, Salerno L, Al Zahrani R, Amata E, Modica MN, Romeo G, Marrazzo A, Prezzavento O, Sorrenti V, Rescifina A, Floresta G, Intagliata S, Pittalà V.

Molecules. 2018 May 18;23(5). pii: E1209. doi: 10.3390/molecules23051209.


Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors.

Salerno L, Amata E, Romeo G, Marrazzo A, Prezzavento O, Floresta G, Sorrenti V, Barbagallo I, Rescifina A, Pittalà V.

Eur J Med Chem. 2018 Mar 25;148:54-62. doi: 10.1016/j.ejmech.2018.02.007. Epub 2018 Feb 9.


Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.

Salerno L, Romeo G, Modica MN, Amata E, Sorrenti V, Barbagallo I, Pittalà V.

Eur J Med Chem. 2017 Dec 15;142:163-178. doi: 10.1016/j.ejmech.2017.07.031. Epub 2017 Jul 20. Review.


Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions.

Pittala V, Vanella L, Salerno L, Romeo G, Marrazzo A, Di Giacomo C, Sorrenti V.

Curr Med Chem. 2018;25(13):1577-1595. doi: 10.2174/0929867324666170616110748. Review.


Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-1.

Pittala V, Vanella L, Salerno L, Di Giacomo C, Acquaviva R, Raffaele M, Romeo G, Modica MN, Prezzavento O, Sorrenti V.

Curr Pharm Des. 2017;23(18):2657-2664. doi: 10.2174/1381612823666170210151411.


Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes.

Pittalà V, Salerno L, Romeo G, Acquaviva R, Di Giacomo C, Sorrenti V.

Curr Med Chem. 2018;25(37):4827-4836. doi: 10.2174/0929867324666161118120908. Review.


Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures.

Acquaviva R, Sorrenti V, Santangelo R, Cardile V, Tomasello B, Malfa G, Vanella L, Amodeo A, Genovese C, Mastrojeni S, Pugliese M, Ragusa M, Di Giacomo C.

Oncol Rep. 2016 Oct;36(4):2298-304. doi: 10.3892/or.2016.5035. Epub 2016 Aug 24.


Caffeic Acid Phenethyl Ester Regulates PPAR's Levels in Stem Cells-Derived Adipocytes.

Vanella L, Tibullo D, Godos J, Pluchinotta FR, Di Giacomo C, Sorrenti V, Acquaviva R, Russo A, Li Volti G, Barbagallo I.

PPAR Res. 2016;2016:7359521. doi: 10.1155/2016/7359521. Epub 2016 Jan 24.


Heme oxygenase levels and metaflammation in benign prostatic hyperplasia patients.

Russo GI, Vanella L, Castelli T, Cimino S, Reale G, Urzì D, Li Volti G, Gacci M, Carini M, Motta F, Caltabiano R, Puzzo L, Sorrenti V, Morgia G.

World J Urol. 2016 Aug;34(8):1183-92. doi: 10.1007/s00345-015-1736-8. Epub 2015 Nov 30.


Cyanidin induces apoptosis and differentiation in prostate cancer cells.

Sorrenti V, Vanella L, Acquaviva R, Cardile V, Giofrè S, Di Giacomo C.

Int J Oncol. 2015 Oct;47(4):1303-10. doi: 10.3892/ijo.2015.3130. Epub 2015 Aug 24.


Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.

Salerno L, Pittalà V, Romeo G, Modica MN, Marrazzo A, Siracusa MA, Sorrenti V, Di Giacomo C, Vanella L, Parayath NN, Greish K.

Eur J Med Chem. 2015;96:162-72. doi: 10.1016/j.ejmech.2015.04.003. Epub 2015 Apr 7.


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