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Items: 1 to 20 of 46


Clogging the Ubiquitin-Proteasome Machinery with Marine Natural Products: Last Decade Update.

Della Sala G, Agriesti F, Mazzoccoli C, Tataranni T, Costantino V, Piccoli C.

Mar Drugs. 2018 Nov 26;16(12). pii: E467. doi: 10.3390/md16120467. Review.


Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea.

Esposito G, Teta R, Della Sala G, Pawlik JR, Mangoni A, Costantino V.

Mar Drugs. 2018 Aug 17;16(8). pii: E285. doi: 10.3390/md16080285.


Smenamide A Analogues. Synthesis and Biological Activity on Multiple Myeloma Cells.

Caso A, Laurenzana I, Lamorte D, Trino S, Esposito G, Piccialli V, Costantino V.

Mar Drugs. 2018 Jun 13;16(6). pii: E206. doi: 10.3390/md16060206.


Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs.

D'Errico S, Borbone N, Catalanotti B, Secondo A, Petrozziello T, Piccialli I, Pannaccione A, Costantino V, Mayol L, Piccialli G, Oliviero G.

Mar Drugs. 2018 Mar 10;16(3). pii: E89. doi: 10.3390/md16030089.


Identification and chemical characterization of N-acyl-homoserine lactone quorum sensing signals across sponge species and time.

Britstein M, Saurav K, Teta R, Sala GD, Bar-Shalom R, Stoppelli N, Zoccarato L, Costantino V, Steindler L.

FEMS Microbiol Ecol. 2018 Feb 1;94(2). doi: 10.1093/femsec/fix182.


Evaluating the Effects of an Organic Extract from the Mediterranean Sponge Geodia cydonium on Human Breast Cancer Cell Lines.

Costantini S, Guerriero E, Teta R, Capone F, Caso A, Sorice A, Romano G, Ianora A, Ruocco N, Budillon A, Costantino V, Costantini M.

Int J Mol Sci. 2017 Oct 9;18(10). pii: E2112. doi: 10.3390/ijms18102112.


Zeamide, a Glycosylinositol Phosphorylceramide with the Novel Core Arap(1β→6)Ins Motif from the Marine Sponge Svenzea zeai.

Della Sala G, Teta R, Esposito G, Pawlik JR, Mangoni A, Costantino V.

Molecules. 2017 Sep 1;22(9). pii: E1455. doi: 10.3390/molecules22091455.


Thermoactinoamide A, an Antibiotic Lipophilic Cyclopeptide from the Icelandic Thermophilic Bacterium Thermoactinomyces vulgaris.

Teta R, Marteinsson VT, Longeon A, Klonowski AM, Groben R, Bourguet-Kondracki ML, Costantino V, Mangoni A.

J Nat Prod. 2017 Sep 22;80(9):2530-2535. doi: 10.1021/acs.jnatprod.7b00560. Epub 2017 Aug 25.


Studies toward the Synthesis of Smenamide A, an Antiproliferative Metabolite from Smenospongia aurea: Total Synthesis of ent-Smenamide A and 16-epi-Smenamide A.

Caso A, Mangoni A, Piccialli G, Costantino V, Piccialli V.

ACS Omega. 2017 Apr 30;2(4):1477-1488. doi: 10.1021/acsomega.7b00095. Epub 2017 Apr 17.


Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation.

Schirmeister T, Oli S, Wu H, Della Sala G, Costantino V, Seo EJ, Efferth T.

Mar Drugs. 2017 Mar 3;15(3). pii: E63. doi: 10.3390/md15030063.


Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita.

Costantino V, Della Sala G, Saurav K, Teta R, Bar-Shalom R, Mangoni A, Steindler L.

Mar Drugs. 2017 Feb 28;15(3). pii: E59. doi: 10.3390/md15030059.


Quorum Sensing Inhibitors from the Sea Discovered Using Bacterial N-acyl-homoserine Lactone-Based Biosensors.

Saurav K, Costantino V, Venturi V, Steindler L.

Mar Drugs. 2017 Feb 23;15(3). pii: E53. doi: 10.3390/md15030053. Review.


Chloromethylhalicyclamine B, a Marine-Derived Protein Kinase CK1δ/ε Inhibitor.

Esposito G, Bourguet-Kondracki ML, Mai LH, Longeon A, Teta R, Meijer L, Van Soest R, Mangoni A, Costantino V.

J Nat Prod. 2016 Nov 23;79(11):2953-2960. Epub 2016 Nov 9.


In Search of Alternative Antibiotic Drugs: Quorum-Quenching Activity in Sponges and their Bacterial Isolates.

Saurav K, Bar-Shalom R, Haber M, Burgsdorf I, Oliviero G, Costantino V, Morgenstern D, Steindler L.

Front Microbiol. 2016 Apr 5;7:416. doi: 10.3389/fmicb.2016.00416. eCollection 2016.


Synthesis of cyclic N (1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells.

Mahal A, D'Errico S, Borbone N, Pinto B, Secondo A, Costantino V, Tedeschi V, Oliviero G, Piccialli V, Piccialli G.

Beilstein J Org Chem. 2015 Dec 22;11:2689-2695. doi: 10.3762/bjoc.11.289. eCollection 2015.


Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis.

Costantino VV, Lobos-Gonzalez L, Ibañez J, Fernandez D, Cuello-Carrión FD, Valenzuela MA, Barbieri MA, Semino SN, Jahn GA, Quest AF, Lopez LA.

Cancer Lett. 2016 Mar 1;372(1):10-23. doi: 10.1016/j.canlet.2015.12.004. Epub 2015 Dec 21.


A New N-Acyl Homoserine Lactone Synthase in an Uncultured Symbiont of the Red Sea Sponge Theonella swinhoei.

Britstein M, Devescovi G, Handley KM, Malik A, Haber M, Saurav K, Teta R, Costantino V, Burgsdorf I, Gilbert JA, Sher N, Venturi V, Steindler L.

Appl Environ Microbiol. 2015 Dec 11;82(4):1274-1285. doi: 10.1128/AEM.03111-15. Print 2016 Feb 15.


Combined LC-MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle.

Teta R, Della Sala G, Glukhov E, Gerwick L, Gerwick WH, Mangoni A, Costantino V.

Environ Sci Technol. 2015 Dec 15;49(24):14301-10. doi: 10.1021/acs.est.5b04415. Epub 2015 Nov 24.


Physiological Functions and Regulation of the Na+/H+ Exchanger [NHE1] in Renal Tubule Epithelial Cells.

Vallés PG, Bocanegra V, Gil Lorenzo A, Costantino VV.

Kidney Blood Press Res. 2015;40(5):452-66. doi: 10.1159/000368521. Epub 2015 Aug 25. Review.


Heat Shock Protein 70 and CHIP Promote Nox4 Ubiquitination and Degradation within the Losartan Antioxidative Effect in Proximal Tubule Cells.

Gil Lorenzo AF, Costantino VV, Appiolaza ML, Cacciamani V, Benardon ME, Bocanegra V, Vallés PG.

Cell Physiol Biochem. 2015;36(6):2183-97. doi: 10.1159/000430184. Epub 2015 Jul 24.

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