Format

Send to

Choose Destination
Int J Mol Sci. 2017 Mar 28;18(4). pii: E709. doi: 10.3390/ijms18040709.

Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds.

Author information

1
Institute of Agro-Environmental and Forest Biology (IBAF-CNR), Via Pietro Castellino 111, 80131 Napoli, Italy. raffaele.conte86@tiscali.it.
2
Institute for Polymers, Composites, and Biomaterials (IPCB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy. valentina.marturano@unina.it.
3
Department of Chemical Sciences, University of Naples "Federico II", Via Cynthia 4, 80125 Napoli, Italy. valentina.marturano@unina.it.
4
Institute of Agro-Environmental and Forest Biology (IBAF-CNR), Via Pietro Castellino 111, 80131 Napoli, Italy. gianfranco.peluso@ibaf.cnr.it.
5
Institute of Agro-Environmental and Forest Biology (IBAF-CNR), Via Pietro Castellino 111, 80131 Napoli, Italy. anna.calarco@ibaf.cnr.it.
6
Institute for Polymers, Composites, and Biomaterials (IPCB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy. cerruti@ipcb.cnr.it.

Abstract

Phytocompounds have been used in medicine for decades owing to their potential in anti-inflammatory applications. However, major difficulties in achieving sustained delivery of phyto-based drugs are related to their low solubility and cell penetration, and high instability. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in the pharmaceutical sector. This review focuses on the recent advances in nanocarrier-mediated drug delivery of bioactive molecules of plant origin in the field of anti-inflammatory research. In particular, special attention is paid to the relationship between structure and properties of the nanocarrier and phytodrug release behavior.

KEYWORDS:

cannabinoids; carbohydrates; essential oils; inflammation; nanocapsules; nanoparticles; nanosized delivery systems; phytochemicals; polyphenols; terpenoids

PMID:
28350317
PMCID:
PMC5412295
DOI:
10.3390/ijms18040709
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center