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Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals.
Muri L, Ispasanie E, Schubart A, Thorburn C, Zamurovic N, Holbro T, Kammüller M, Pluschke G. Muri L, et al. Front Immunol. 2021 Oct 11;12:732146. doi: 10.3389/fimmu.2021.732146. eCollection 2021. Front Immunol. 2021. PMID: 34707606 Free PMC article.
Pneumococcal killing was measured in the presence of inhibitors targeting the complement components C3, C5, MASP-2, factor B or factor D. The two assay formats yielded highly consistent and comparable results. ...Independent of amplification by the alternative pathway, eve …
Pneumococcal killing was measured in the presence of inhibitors targeting the complement components C3, C5, MASP-2, factor B or facto …
Uranium Going the Soft Way: Low-Valent Uranium(III) Coordinated to an Arene-Anchored Tris-Thiophenolate Ligand.
Pividori D, Miehlich ME, Kestel B, Heinemann FW, Scheurer A, Patzschke M, Meyer K. Pividori D, et al. Inorg Chem. 2021 Nov 1;60(21):16455-16465. doi: 10.1021/acs.inorgchem.1c02310. Epub 2021 Oct 22. Inorg Chem. 2021. PMID: 34677061
The synthesis of a tripodal, S-based ligand, namely the mesitylene-anchored, tris-thiophenolate-functionalized (mes((Me,Ad)ArS)(3))(3-) (1)(3-), and its coordination chemistry with low-valent uranium to form [U(III)((SAr(Ad,Me))(3)mes)] (1-U) are reported. .. …
The synthesis of a tripodal, S-based ligand, namely the mesitylene-anchored, tris-thiophenolate-functionalized (mes((Me,Ad)ArS)(3))(3 …
Immunization with a streptococcal multiple-epitope recombinant protein protects mice against invasive group A streptococcal infection.
Kuo CF, Tsao N, Hsieh IC, Lin YS, Wu JJ, Hung YT. Kuo CF, et al. PLoS One. 2017 Mar 29;12(3):e0174464. doi: 10.1371/journal.pone.0174464. eCollection 2017. PLoS One. 2017. PMID: 28355251 Free PMC article.
A number of group A streptococcus vaccine candidates have been developed, but only one 26-valent recombinant M protein vaccine has entered clinical trials. Differing from the design of a 26-valent recombinant M protein vaccine, we provide here a vaccination using th …
A number of group A streptococcus vaccine candidates have been developed, but only one 26-valent recombinant M protein vaccine has en …
Metal-metal interactions in C3-symmetric diiron imido complexes linked by phosphinoamide ligands.
Kuppuswamy S, Powers TM, Johnson BM, Bezpalko MW, Brozek CK, Foxman BM, Berben LA, Thomas CM. Kuppuswamy S, et al. Inorg Chem. 2013 May 6;52(9):4802-11. doi: 10.1021/ic302108k. Epub 2012 Dec 24. Inorg Chem. 2013. PMID: 23259457
Following a typical oxidative group transfer procedure, treatment of 2 or 3 with organic azides generates the mixed-valent Fe(II)Fe(III) imido complexes Fe((i)PrNPPh2)3FeNR (R = (t)Bu (4), Ad (5), 2,4,6-trimethylphenyl (6)). ...
Following a typical oxidative group transfer procedure, treatment of 2 or 3 with organic azides generates the mixed-valent Fe(II)Fe(I …
Oxidation state delineation via U L(III)-edge XANES in a series of isostructural uranium coordination complexes.
Kosog B, La Pierre HS, Denecke MA, Heinemann FW, Meyer K. Kosog B, et al. Inorg Chem. 2012 Jul 16;51(14):7940-4. doi: 10.1021/ic3011234. Epub 2012 Jul 5. Inorg Chem. 2012. PMID: 22765506
These compounds were obtained through the activation of small molecules, such as ketones, azides, and carbon dioxide, and upon oxidation of a high-valent U(V)O to [U(VI)O](+). Most of the compounds have been reported previously. ...Each uranium complex consists of a triaza …
These compounds were obtained through the activation of small molecules, such as ketones, azides, and carbon dioxide, and upon oxidation of …
New insights on pneumococcal disease: what we have learned over the past decade.
Dagan R. Dagan R. Vaccine. 2009 Aug 21;27 Suppl 3:C3-5. doi: 10.1016/j.vaccine.2009.06.002. Epub 2009 Jun 23. Vaccine. 2009. PMID: 19552985
Since the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) in 2000, significant reductions in the rate of invasive pneumococcal diseases (IPDs) and mucosal infections caused by vaccine-specific serotypes have been observed in the targeted population ( …
Since the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) in 2000, significant reductions in the rate of invas …