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Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.

Stiborová M, Indra R, Frei E, Kopečková K, Schmeiser HH, Eckschlager T, Adam V, Heger Z, Arlt VM, Martínek V.

Monatsh Chem. 2017;148(11):1983-1991. doi: 10.1007/s00706-017-1986-9. Epub 2017 Jul 4.


Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.

Martínek V, Bárta F, Hodek P, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Monatsh Chem. 2017;148(11):1971-1981. doi: 10.1007/s00706-017-2014-9. Epub 2017 Jul 26.


Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction.

Stranava M, Man P, Skálová T, Kolenko P, Blaha J, Fojtikova V, Martínek V, Dohnálek J, Lengalova A, Rosůlek M, Shimizu T, Martínková M.

J Biol Chem. 2017 Dec 22;292(51):20921-20935. doi: 10.1074/jbc.M117.817023. Epub 2017 Nov 1.


Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2.

Jeřábek P, Florián J, Martínek V.

Phys Chem Chem Phys. 2016 Nov 9;18(44):30344-30356.


Structural characterization of the heme-based oxygen sensor, AfGcHK, its interactions with the cognate response regulator, and their combined mechanism of action in a bacterial two-component signaling system.

Stranava M, Martínek V, Man P, Fojtikova V, Kavan D, Vaněk O, Shimizu T, Martinkova M.

Proteins. 2016 Oct;84(10):1375-89. doi: 10.1002/prot.25083. Epub 2016 Jun 23.


Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).

Stiborová M, Moserová M, Mrízová I, Dračínská H, Martínek V, Indra R, Frei E, Adam V, Kizek R, Schmeiser HH, Kubáčková K, Arlt VM.

Monatsh Chem. 2016;147:897-904. Epub 2016 Jan 12.


Membrane-Anchored Cytochrome P450 1A2-Cytochrome b5 Complex Features an X-Shaped Contact between Antiparallel Transmembrane Helices.

Jeřábek P, Florián J, Martínek V.

Chem Res Toxicol. 2016 Apr 18;29(4):626-36. doi: 10.1021/acs.chemrestox.5b00349. Epub 2016 Mar 16.


Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.

Milichovský J, Bárta F, Schmeiser HH, Arlt VM, Frei E, Stiborová M, Martínek V.

Int J Mol Sci. 2016 Feb 5;17(2):213. doi: 10.3390/ijms17020213.


Ferrous and ferric state of cytochromes P450 in intact Escherichia coli cells: a possible role of cytochrome P450-flavodoxin interactions.

Culka M, Milichovsky J, Jerabek P, Stiborova M, Martinek V.

Neuro Endocrinol Lett. 2015;36 Suppl 1:29-37.


Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae.

Kuipers K, Gallay C, Martínek V, Rohde M, Martínková M, van der Beek SL, Jong WS, Venselaar H, Zomer A, Bootsma H, Veening JW, de Jonge MI.

Mol Microbiol. 2016 Jul;101(1):12-26. doi: 10.1111/mmi.13312. Epub 2016 Feb 19.


A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.

Stiborová M, Bárta F, Levová K, Hodek P, Schmeiser HH, Arlt VM, Martínek V.

Int J Mol Sci. 2015 Nov 18;16(11):27561-75. doi: 10.3390/ijms161126047.


Enzymes oxidizing the azo dye 1-phenylazo-2-naphthol (Sudan I) and their contribution to its genotoxicity and carcinogenicity.

Stiborova M, Schmeiser HH, Frei E, Hodek P, Martinek V.

Curr Drug Metab. 2014;15(8):829-40. Review.


Flexible docking-based molecular dynamics/steered molecular dynamics calculations of protein-protein contacts in a complex of cytochrome P450 1A2 with cytochrome b5.

Jeřábek P, Florián J, Stiborová M, Martínek V.

Biochemistry. 2014 Oct 28;53(42):6695-705. doi: 10.1021/bi500814t. Epub 2014 Oct 14.


Introduction of water into the heme distal side by Leu65 mutations of an oxygen sensor, YddV, generates verdoheme and carbon monoxide, exerting the heme oxygenase reaction.

Stranava M, Martínková M, Stiborová M, Man P, Kitanishi K, Muchová L, Vítek L, Martínek V, Shimizu T.

J Inorg Biochem. 2014 Nov;140:29-38. doi: 10.1016/j.jinorgbio.2014.06.010. Epub 2014 Jun 24.


Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.

Stiborová M, Frei E, Schmeiser HH, Arlt VM, Martínek V.

Int J Mol Sci. 2014 Jun 10;15(6):10271-95. doi: 10.3390/ijms150610271. Review.


Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer.

Stiborová M, Martínek V, Frei E, Arlt VM, Schmeiser HH.

Curr Drug Metab. 2013 Jul;14(6):695-705. Review.


Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations.

Sulc M, Jecmen T, Snajdrova R, Novak P, Martinek V, Hodek P, Stiborova M, Hudecek J.

Neuro Endocrinol Lett. 2012;33 Suppl 3:41-7.


Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1.

Jerabek P, Martinek V, Stiborova M.

Neuro Endocrinol Lett. 2012;33 Suppl 3:25-32.


Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).

Stiborová M, Dračínská H, Martínek V, Svášková D, Hodek P, Milichovský J, Hejduková Ž, Brotánek J, Schmeiser HH, Frei E.

Chem Res Toxicol. 2013 Feb 18;26(2):290-9. doi: 10.1021/tx3004533. Epub 2013 Jan 15.


Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.

Stiborová M, Indra R, Moserová M, Cerná V, Rupertová M, Martínek V, Eckschlager T, Kizek R, Frei E.

Chem Res Toxicol. 2012 May 21;25(5):1075-85. doi: 10.1021/tx3000335. Epub 2012 Mar 15.


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