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Items: 1 to 20 of 80


Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1.

Greco FA, Albini E, Coletti A, Dolciami D, Carotti A, Orabona C, Grohmann U, Macchiarulo A.

ChemMedChem. 2019 Nov 14. doi: 10.1002/cmdc.201900529. [Epub ahead of print]


Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells.

Gargaro M, Vacca C, Massari S, Scalisi G, Manni G, Mondanelli G, Mazza EMC, Bicciato S, Pallotta MT, Orabona C, Belladonna ML, Volpi C, Bianchi R, Matino D, Iacono A, Panfili E, Proietti E, Iamandii IM, Cecchetti V, Puccetti P, Tabarrini O, Fallarino F, Grohmann U.

Front Immunol. 2019 Aug 20;10:1973. doi: 10.3389/fimmu.2019.01973. eCollection 2019.


Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis.

Volpi C, Orabona C, Macchiarulo A, Bianchi R, Puccetti P, Grohmann U.

Expert Opin Drug Discov. 2019 Nov;14(11):1199-1212. doi: 10.1080/17460441.2019.1646244. Epub 2019 Aug 7.


Immunoregulatory Interplay Between Arginine and Tryptophan Metabolism in Health and Disease.

Mondanelli G, Iacono A, Allegrucci M, Puccetti P, Grohmann U.

Front Immunol. 2019 Jul 9;10:1565. doi: 10.3389/fimmu.2019.01565. eCollection 2019. No abstract available.


Wolfram syndrome, a rare neurodegenerative disease: from pathogenesis to future treatment perspectives.

Pallotta MT, Tascini G, Crispoldi R, Orabona C, Mondanelli G, Grohmann U, Esposito S.

J Transl Med. 2019 Jul 23;17(1):238. doi: 10.1186/s12967-019-1993-1. Review.


Effects of probiotic administration on immune responses of children and adolescents with type 1 diabetes to a quadrivalent inactivated influenza vaccine.

Bianchini S, Orabona C, Camilloni B, Berioli MG, Argentiero A, Matino D, Alunno A, Albini E, Vacca C, Pallotta MT, Mancini G, Tascini G, Toni G, Mondanelli G, Silvestri E, Grohmann U, Esposito S.

Hum Vaccin Immunother. 2019 Aug 15:1-9. doi: 10.1080/21645515.2019.1633877. [Epub ahead of print]


Amino acid metabolism as drug target in autoimmune diseases.

Mondanelli G, Iacono A, Carvalho A, Orabona C, Volpi C, Pallotta MT, Matino D, Esposito S, Grohmann U.

Autoimmun Rev. 2019 Apr;18(4):334-348. doi: 10.1016/j.autrev.2019.02.004. Epub 2019 Feb 22. Review.


IL-35Ig-expressing dendritic cells induce tolerance via Arginase 1.

Panfili E, Mondanelli G, Orabona C, Bianchi R, Gargaro M, Fallarino F, Puccetti P, Grohmann U, Volpi C, Belladonna ML.

J Cell Mol Med. 2019 May;23(5):3757-3761. doi: 10.1111/jcmm.14215. Epub 2019 Feb 22.


Induction of immunosuppressive functions and NF-κB by FLIP in monocytes.

Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, Sartoris S, Solito S, Mandruzzato S, Vascotto F, Hippen KL, Mondanelli G, Grohmann U, Piro G, Carbone C, Melisi D, Lawlor RT, Scarpa A, Lamolinara A, Iezzi M, Fassan M, Bicciato S, Blazar BR, Sahin U, Murray PJ, Bronte V.

Nat Commun. 2018 Dec 5;9(1):5193. doi: 10.1038/s41467-018-07654-4.


Is It Time to Use Probiotics to Prevent or Treat Obesity?

Brusaferro A, Cozzali R, Orabona C, Biscarini A, Farinelli E, Cavalli E, Grohmann U, Principi N, Esposito S.

Nutrients. 2018 Nov 1;10(11). pii: E1613. doi: 10.3390/nu10111613. Review.


Immune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes.

Orabona C, Mondanelli G, Puccetti P, Grohmann U.

Trends Mol Med. 2018 Nov;24(11):931-941. doi: 10.1016/j.molmed.2018.08.005. Epub 2018 Sep 17. Review.


Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.

Anquetil F, Mondanelli G, Gonzalez N, Rodriguez Calvo T, Zapardiel Gonzalo J, Krogvold L, Dahl-Jørgensen K, Van den Eynde B, Orabona C, Grohmann U, von Herrath MG.

Diabetes. 2018 Sep;67(9):1858-1866. doi: 10.2337/db17-1281. Epub 2018 Jun 26.


Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

Orabona C, Mondanelli G, Pallotta MT, Carvalho A, Albini E, Fallarino F, Vacca C, Volpi C, Belladonna ML, Berioli MG, Ceccarini G, Esposito SM, Scattoni R, Verrotti A, Ferretti A, De Giorgi G, Toni S, Cappa M, Matteoli MC, Bianchi R, Matino D, Iacono A, Puccetti M, Cunha C, Bicciato S, Antognelli C, Talesa VN, Chatenoud L, Fuchs D, Pilotte L, Van den Eynde B, Lemos MC, Romani L, Puccetti P, Grohmann U.

JCI Insight. 2018 Mar 22;3(6). pii: 96244. doi: 10.1172/jci.insight.96244.


Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4.

Volpi C, Fallarino F, Mondanelli G, Macchiarulo A, Grohmann U.

Expert Opin Drug Discov. 2018 May;13(5):411-423. doi: 10.1080/17460441.2018.1443076. Epub 2018 Feb 28. Review.


Fragment-based approach to identify IDO1 inhibitor building blocks.

Coletti A, Camponeschi F, Albini E, Greco FA, Maione V, Custodi C, Ianni F, Grohmann U, Orabona C, Cantini F, Macchiarulo A.

Eur J Med Chem. 2017 Dec 1;141:169-177. doi: 10.1016/j.ejmech.2017.09.044. Epub 2017 Oct 3.


Eating Disorders and Disordered Eating Symptoms in Adolescents with Type 1 Diabetes.

Toni G, Berioli MG, Cerquiglini L, Ceccarini G, Grohmann U, Principi N, Esposito S.

Nutrients. 2017 Aug 19;9(8). pii: E906. doi: 10.3390/nu9080906. Review.


Challenges in the design of reliable immuno-oncology mouse models to inform drug development.

Mondanelli G, Volpi C, Orabona C, Grohmann U.

Future Med Chem. 2017 Aug;9(12):1313-1317. doi: 10.4155/fmc-2017-0027. Epub 2017 Aug 3. No abstract available.


The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO.

Mondanelli G, Ugel S, Grohmann U, Bronte V.

Curr Opin Pharmacol. 2017 Aug;35:30-39. doi: 10.1016/j.coph.2017.05.002. Epub 2017 May 26. Review.


Amino-acid sensing and degrading pathways in immune regulation.

Grohmann U, Mondanelli G, Belladonna ML, Orabona C, Pallotta MT, Iacono A, Puccetti P, Volpi C.

Cytokine Growth Factor Rev. 2017 Jun;35:37-45. doi: 10.1016/j.cytogfr.2017.05.004. Epub 2017 May 18. Review.


Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry.

Coletti A, Greco FA, Dolciami D, Camaioni E, Sardella R, Pallotta MT, Volpi C, Orabona C, Grohmann U, Macchiarulo A.

Medchemcomm. 2017 May 16;8(7):1378-1392. doi: 10.1039/c7md00109f. eCollection 2017 Jul 1. Review.

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