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Proteomes. 2017 Oct 11;5(4). pii: E26. doi: 10.3390/proteomes5040026.

Proteogenomics in Aid of Host-Pathogen Interaction Studies: A Bacterial Perspective.

Author information

1
VIB-UGent Center for Medical Biotechnology, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium. ursula.fels@vib-ugent.be.
2
Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium. ursula.fels@vib-ugent.be.
3
VIB-UGent Center for Medical Biotechnology, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium. kris.gevaert@vib-ugent.be.
4
Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium. kris.gevaert@vib-ugent.be.
5
VIB-UGent Center for Medical Biotechnology, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium. petra.vandamme@vib-ugent.be.
6
Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium. petra.vandamme@vib-ugent.be.

Abstract

By providing useful tools to study host-pathogen interactions, next-generation omics has recently enabled the study of gene expression changes in both pathogen and infected host simultaneously. However, since great discriminative power is required to study pathogen and host simultaneously throughout the infection process, the depth of quantitative gene expression profiling has proven to be unsatisfactory when focusing on bacterial pathogens, thus preferentially requiring specific strategies or the development of novel methodologies based on complementary omics approaches. In this review, we focus on the difficulties encountered when making use of proteogenomics approaches to study bacterial pathogenesis. In addition, we review different omics strategies (i.e., transcriptomics, proteomics and secretomics) and their applications for studying interactions of pathogens with their host.

KEYWORDS:

bacterial pathogens; host–pathogen interaction; infection biology; proteogenomics

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