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Items: 1 to 20 of 23

1.

Aryl azides as forgotten electrophiles in the Van Leusen reaction: a multicomponent transformation affording 4-tosyl-1-arylimidazoles.

Necardo C, Alfano AI, Del Grosso E, Pelliccia S, Galli U, Novellino E, Meneghetti F, Giustiniano M, Tron GC.

J Org Chem. 2019 Nov 29. doi: 10.1021/acs.joc.9b02546. [Epub ahead of print]

PMID:
31779310
2.

Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group.

Travelli C, Aprile S, Mattoteia D, Colombo G, Clemente N, Scanziani E, Terrazzino S, Alisi MA, Polenzani L, Grosa G, Genazzani AA, Tron GC, Galli U.

Eur J Med Chem. 2019 Nov 1;181:111576. doi: 10.1016/j.ejmech.2019.111576. Epub 2019 Aug 1.

PMID:
31400709
3.

Study of Anopheles gambiae 3-hydroxykynurenine transaminase activity and inhibition by LC-MS/MS method.

Canavesi R, Miggiano R, Stella M, Galli U, Rossi F, Rizzi M, Del Grosso E.

J Pharm Biomed Anal. 2019 Sep 5;173:154-161. doi: 10.1016/j.jpba.2019.05.025. Epub 2019 May 13.

PMID:
31129535
4.

Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines.

Galli U, Hysenlika R, Meneghetti F, Del Grosso E, Pelliccia S, Novellino E, Giustiniano M, Tron GC.

Molecules. 2019 May 21;24(10). pii: E1959. doi: 10.3390/molecules24101959.

5.

Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction.

Pirali T, Galli U, Serafini M, Griglio A, Genazzani AA, Tron GC.

Methods Mol Biol. 2019;1987:207-221. doi: 10.1007/978-1-4939-9446-5_13.

PMID:
31028682
6.

Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.

Travelli C, Consonni FM, Sangaletti S, Storto M, Morlacchi S, Grolla AA, Galli U, Tron GC, Portararo P, Rimassa L, Pressiani T, Mazzone M, Trovato R, Ugel S, Bronte V, Tripodo C, Colombo MP, Genazzani AA, Sica A.

Cancer Res. 2019 Apr 15;79(8):1938-1951. doi: 10.1158/0008-5472.CAN-18-1544. Epub 2019 Feb 18.

PMID:
30777853
7.

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis.

Riva B, Griglio A, Serafini M, Cordero-Sanchez C, Aprile S, Di Paola R, Gugliandolo E, Alansary D, Biocotino I, Lim D, Grosa G, Galli U, Niemeyer B, Sorba G, Canonico PL, Cuzzocrea S, Genazzani AA, Pirali T.

J Med Chem. 2018 Nov 8;61(21):9756-9783. doi: 10.1021/acs.jmedchem.8b01512. Epub 2018 Oct 30.

PMID:
30347159
8.

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC.

J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22.

PMID:
28165742
9.

A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids.

Giustiniano M, Pelliccia S, Galli U, Amato J, Travagin F, Novellino E, Tron GC.

J Org Chem. 2016 Nov 18;81(22):11467-11471. Epub 2016 Oct 26.

PMID:
27755877
10.

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.

Galli U, Ciraolo E, Massarotti A, Margaria JP, Sorba G, Hirsch E, Tron GC.

Molecules. 2015 Sep 18;20(9):17275-87. doi: 10.3390/molecules200917275.

11.

Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.

Galli U, Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC.

J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389. Epub 2015 Jan 27.

PMID:
25584687
12.

Reaction between (Z)-arylchlorooximes and α-isocyanoacetamides: a procedure for the synthesis of aryl-α-ketoamide amides.

Giustiniano M, Mercalli V, Cassese H, Di Maro S, Galli U, Novellino E, Tron GC.

J Org Chem. 2014 Jul 3;79(13):6006-14. doi: 10.1021/jo5005444. Epub 2014 Jun 20.

PMID:
24914772
13.

Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

Galli U, Travelli C, Massarotti A, Fakhfouri G, Rahimian R, Tron GC, Genazzani AA.

J Med Chem. 2013 Aug 22;56(16):6279-96. doi: 10.1021/jm4001049. Epub 2013 May 31. Review.

PMID:
23679915
14.

Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed in melanoma lesions.

Maldi E, Travelli C, Caldarelli A, Agazzone N, Cintura S, Galli U, Scatolini M, Ostano P, Miglino B, Chiorino G, Boldorini R, Genazzani AA.

Pigment Cell Melanoma Res. 2013 Jan;26(1):144-6. doi: 10.1111/pcmr.12037. Epub 2012 Nov 12. No abstract available.

PMID:
23051650
15.

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.

Galli U, Mesenzani O, Coppo C, Sorba G, Canonico PL, Tron GC, Genazzani AA.

Eur J Med Chem. 2012 Sep;55:58-66. doi: 10.1016/j.ejmech.2012.07.001. Epub 2012 Jul 15.

PMID:
22835719
16.

Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells.

Travelli C, Drago V, Maldi E, Kaludercic N, Galli U, Boldorini R, Di Lisa F, Tron GC, Canonico PL, Genazzani AA.

J Pharmacol Exp Ther. 2011 Sep;338(3):829-40. doi: 10.1124/jpet.111.184630. Epub 2011 Jun 17.

PMID:
21685314
17.

A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.

Colombano G, Travelli C, Galli U, Caldarelli A, Chini MG, Canonico PL, Sorba G, Bifulco G, Tron GC, Genazzani AA.

J Med Chem. 2010 Jan 28;53(2):616-23. doi: 10.1021/jm9010669.

PMID:
19961183
18.

Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage.

Galli U, Ercolano E, Carraro L, Blasi Roman CR, Sorba G, Canonico PL, Genazzani AA, Tron GC, Billington RA.

ChemMedChem. 2008 May;3(5):771-9. doi: 10.1002/cmdc.200700311.

PMID:
18247435
19.

Characterization of NAD uptake in mammalian cells.

Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA.

J Biol Chem. 2008 Mar 7;283(10):6367-74. doi: 10.1074/jbc.M706204200. Epub 2008 Jan 7.

20.

Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry.

Imperio D, Pirali T, Galli U, Pagliai F, Cafici L, Canonico PL, Sorba G, Genazzani AA, Tron GC.

Bioorg Med Chem. 2007 Nov 1;15(21):6748-57. Epub 2007 Aug 22.

PMID:
17765552

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