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Items: 1 to 20 of 21

1.

Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan.

Harkness TAA.

Int J Mol Sci. 2018 Jun 27;19(7). pii: E1888. doi: 10.3390/ijms19071888. Review.

2.

Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance.

Malo ME, Postnikoff SD, Arnason TG, Harkness TA.

Aging (Albany NY). 2016 Apr;8(4):810-30. doi: 10.18632/aging.100949.

3.

A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan.

Ghavidel A, Baxi K, Ignatchenko V, Prusinkiewicz M, Arnason TG, Kislinger T, Carvalho CE, Harkness TA.

PLoS Genet. 2015 Aug 6;11(8):e1005429. doi: 10.1371/journal.pgen.1005429. eCollection 2015 Aug.

4.

Living longer through mitochondrial housekeeping.

Harkness TA.

Cell Cycle. 2015;14(12):1770. doi: 10.1080/15384101.2015.1046792. No abstract available.

5.

Replicative and chronological life-span assays.

Postnikoff SD, Harkness TA.

Methods Mol Biol. 2014;1163:223-7. doi: 10.1007/978-1-4939-0799-1_17.

PMID:
24841311
6.

TFPI1 mediates resistance to doxorubicin in breast cancer cells by inducing a hypoxic-like response.

Davies GF, Berg A, Postnikoff SD, Wilson HL, Arnason TG, Kusalik A, Harkness TA.

PLoS One. 2014 Jan 28;9(1):e84611. doi: 10.1371/journal.pone.0084611. eCollection 2014.

7.

The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation.

Menzel J, Malo ME, Chan C, Prusinkiewicz M, Arnason TG, Harkness TA.

Genetics. 2014 Mar;196(3):693-709. doi: 10.1534/genetics.113.158949. Epub 2013 Dec 20.

8.

The spatiotemporal dynamics of longevity-defining cellular processes and its modulation by genetic, dietary, and pharmacological anti-aging interventions.

Titorenko VI, Harkness TA.

Front Physiol. 2012 Oct 31;3:419. doi: 10.3389/fphys.2012.00419. eCollection 2012. No abstract available.

9.

The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex.

Postnikoff SD, Malo ME, Wong B, Harkness TA.

PLoS Genet. 2012;8(3):e1002583. doi: 10.1371/journal.pgen.1002583. Epub 2012 Mar 15.

10.

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells.

Goldberg AA, Beach A, Davies GF, Harkness TA, Leblanc A, Titorenko VI.

Oncotarget. 2011 Oct;2(10):761-82.

11.

A role for the anaphase promoting complex in hormone regulation.

Lindsay DL, Bonham-Smith PC, Postnikoff S, Gray GR, Harkness TA.

Planta. 2011 Jun;233(6):1223-35. doi: 10.1007/s00425-011-1374-3. Epub 2011 Feb 17.

PMID:
21327815
12.

The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression.

Turner EL, Malo ME, Pisclevich MG, Dash MD, Davies GF, Arnason TG, Harkness TA.

Eukaryot Cell. 2010 Oct;9(10):1418-31. doi: 10.1128/EC.00097-10. Epub 2010 Aug 13.

13.

Troglitazone reverses the multiple drug resistance phenotype in cancer cells.

Davies GF, Juurlink BH, Harkness TA.

Drug Des Devel Ther. 2009 Sep 21;3:79-88.

14.

Phase 2 protein inducers in the diet promote healthier aging.

Noyan-Ashraf MH, Sadeghinejad Z, Davies GF, Ross AR, Saucier D, Harkness TA, Juurlink BH.

J Gerontol A Biol Sci Med Sci. 2008 Nov;63(11):1168-76.

PMID:
19038831
15.

Decondensation of Xenopus sperm chromatin using Saccharomyces cerevisiae whole-cell extracts.

Harkness TA.

Can J Physiol Pharmacol. 2006 Mar-Apr;84(3-4):451-8.

PMID:
16902590
16.

Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells.

Davies GF, Roesler WJ, Juurlink BH, Harkness TA.

Leuk Lymphoma. 2005 Aug;46(8):1199-206.

PMID:
16085563
17.

Contribution of CAF-I to anaphase-promoting-complex-mediated mitotic chromatin assembly in Saccharomyces cerevisiae.

Harkness TA, Arnason TG, Legrand C, Pisclevich MG, Davies GF, Turner EL.

Eukaryot Cell. 2005 Apr;4(4):673-84.

18.

Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae.

Arnason TG, Pisclevich MG, Dash MD, Davies GF, Harkness TA.

Eukaryot Cell. 2005 Jan;4(1):134-46.

19.

A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast.

Harkness TA, Shea KA, Legrand C, Brahmania M, Davies GF.

Genetics. 2004 Oct;168(2):759-74.

20.

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