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Preventive Effects of Fermented Brown Rice and Rice Bran on Spontaneous Lymphomagenesis in AKR/NSlc Female Mice

Kuno T, Kato H, Naiki-Ito A, Suzuki S, Tanaka T, Takahashi S, Mori H.

Asian Pac J Cancer Prev. 2018 Nov 29;19(11):3217-3223.


An Increased Chromosome 7 Copy Number in Endoscopic Bile Duct Biopsy Specimens Is Predictive of a Poor Prognosis in Cholangiocarcinoma.

Kato A, Naitoh I, Miyabe K, Hayashi K, Yoshida M, Hori Y, Natsume M, Jinno N, Asano G, Kato H, Kuno T, Takahashi S, Kataoka H.

Dig Dis Sci. 2018 Dec;63(12):3376-3381. doi: 10.1007/s10620-018-5280-4. Epub 2018 Sep 12.


Chemopreventive effects of angiotensin II receptor type 2 agonist on prostate carcinogenesis by the down-regulation of the androgen receptor.

Ito Y, Naiki-Ito A, Kato H, Suzuki S, Kuno T, Ishiguro Y, Takahashi S, Uemura H.

Oncotarget. 2018 Feb 14;9(17):13859-13869. doi: 10.18632/oncotarget.24492. eCollection 2018 Mar 2.


Differential diagnosis of cholangiocarcinoma and IgG4-related sclerosing cholangitis by fluorescence in situ hybridization using transpapillary forceps biopsy specimens.

Kato A, Naitoh I, Miyabe K, Hayashi K, Kondo H, Yoshida M, Kato H, Kuno T, Takahashi S, Joh T.

J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):188-194. doi: 10.1002/jhbp.536.


The NADPH Oxidase Inhibitor Apocynin Suppresses Preneoplastic Liver Foci of Rats.

Fuji S, Suzuki S, Naiki-Ito A, Kato H, Hayakawa M, Yamashita Y, Kuno T, Takahashi S.

Toxicol Pathol. 2017 Jun;45(4):544-550. doi: 10.1177/0192623317710013. Epub 2017 Jun 2.


Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist, Suppresses Rat Prostate Carcinogenesis.

Suzuki S, Mori Y, Nagano A, Naiki-Ito A, Kato H, Nagayasu Y, Kobayashi M, Kuno T, Takahashi S.

Int J Mol Sci. 2016 Dec 10;17(12). pii: E2071.


Ectopic Gastric and Intestinal Phenotypes, Neuroendocrine Cell Differentiation, and SOX2 Expression Correlated With Early Tumor Progression in Colorectal Laterally Spreading Tumors.

Katano T, Mizoshita T, Tsukamoto H, Nishie H, Inagaki Y, Hayashi N, Nomura S, Ozeki K, Okamoto Y, Shimura T, Mori Y, Kubota E, Tanida S, Kataoka H, Kuno T, Takahashi S, Joh T.

Clin Colorectal Cancer. 2017 Jun;16(2):141-146. doi: 10.1016/j.clcc.2016.09.009. Epub 2016 Oct 6.


Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats.

Kuno T, Nagano A, Mori Y, Kato H, Nagayasu Y, Naiki-Ito A, Suzuki S, Mori H, Takahashi S.

Nutrients. 2016 Jul 11;8(7). pii: E421. doi: 10.3390/nu8070421.


IgG4-related Sclerosing Cholangitis with No Biliary Stricture but Severe Thickening of the Bile Duct Wall.

Shimizu S, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Kuno T, Takahashi S, Joh T.

Intern Med. 2016;55(12):1575-9. doi: 10.2169/internalmedicine.55.6302. Epub 2016 Jun 15.


SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.

Johmura Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki-Ito A, Sawada Y, Miyamoto T, Okabe A, Aburatani H, Li S, Miyoshi I, Takahashi S, Kitagawa M, Nakanishi M.

Nat Commun. 2016 Feb 12;7:10574. doi: 10.1038/ncomms10574.


Preventive effects of fermented brown rice and rice bran against N-nitrosobis (2-oxopropyl) amine-induced pancreatic tumorigenesis in male hamsters.

Kuno T, Takahashi S, Tomita H, Hisamatsu K, Hara A, Hirata A, Kobayashi H, Mori H.

Oncol Lett. 2015 Dec;10(6):3377-3384. Epub 2015 Oct 16.


Predictive factors for positive diagnosis of malignant biliary strictures by transpapillary brush cytology and forceps biopsy.

Naitoh I, Nakazawa T, Kato A, Hayashi K, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kuno T, Takahashi S, Ohara H, Joh T.

J Dig Dis. 2016 Jan;17(1):44-51. doi: 10.1111/1751-2980.12311.


Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis.

Kato H, Naiki-Ito A, Naiki T, Suzuki S, Yamashita Y, Sato S, Sagawa H, Kato A, Kuno T, Takahashi S.

Oncotarget. 2016 Jan 12;7(2):2009-21. doi: 10.18632/oncotarget.6511.


Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2.

Kato A, Naiki-Ito A, Nakazawa T, Hayashi K, Naitoh I, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Mori T, Tsutsumi M, Kuno T, Suzuki S, Kato H, Ohara H, Joh T, Takahashi S.

Oncotarget. 2015 Dec 15;6(40):42963-75. doi: 10.18632/oncotarget.5981.


Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats.

Sagawa H, Naiki-Ito A, Kato H, Naiki T, Yamashita Y, Suzuki S, Sato S, Shiomi K, Kato A, Kuno T, Matsuo Y, Kimura M, Takeyama H, Takahashi S.

Carcinogenesis. 2015 Dec;36(12):1539-49. doi: 10.1093/carcin/bgv143. Epub 2015 Oct 22.


Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice.

Takamatsu M, Hirata A, Ohtaki H, Hoshi M, Ando T, Ito H, Hatano Y, Tomita H, Kuno T, Saito K, Seishima M, Hara A.

Cancer Sci. 2015 Aug;106(8):1008-15. doi: 10.1111/cas.12705. Epub 2015 Jul 14.


Establishment of a syngeneic orthotopic model of prostate cancer in immunocompetent rats.

Suzuki S, Naiki-Ito A, Kuno T, Punfa W, Long N, Kato H, Inaguma S, Komiya M, Shirai T, Takahashi S.

J Toxicol Pathol. 2015 Jan;28(1):21-6. doi: 10.1293/tox.2014-0050. Epub 2014 Dec 18. Erratum in: J Toxicol Pathol. 2016 Jan;29(1):74.


Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation.

Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, Yamada Y.

Carcinogenesis. 2015 Jul;36(7):719-29. doi: 10.1093/carcin/bgv060. Epub 2015 May 4.


Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis.

Naiki-Ito A, Chewonarin T, Tang M, Pitchakarn P, Kuno T, Ogawa K, Asamoto M, Shirai T, Takahashi S.

Prostate. 2015 Feb;75(2):151-60. doi: 10.1002/pros.22900. Epub 2014 Oct 4.


The peroxisome proliferator-activated receptor (PPAR) α agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice.

Kuno T, Hata K, Takamatsu M, Hara A, Hirose Y, Takahashi S, Imaida K, Tanaka T.

Int J Mol Sci. 2014 May 22;15(5):9160-72. doi: 10.3390/ijms15059160.

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