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Items: 1 to 20 of 154

1.

Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesis.

Matsuura T, Maru Y, Izumiya M, Hoshi D, Kato S, Ochiai M, Hori M, Yamamoto S, Tatsuno K, Imai T, Aburatani H, Nakajima A, Hippo Y.

Carcinogenesis. 2019 Jun 22. pii: bgz122. doi: 10.1093/carcin/bgz122. [Epub ahead of print]

PMID:
31233118
2.

Blockade of the CX3CL1-CX3CR1 Pathway Inhibits the Progress of Skin Inflammation, Fibrosis, and Vascular Injury in an Experimental Mouse Model of Systemic Sclerosis.

Luong VH, Utsunomiya A, Chino T, Le DH, Matsushita T, Obara T, Kuboi Y, Ishii N, Machinaga A, Ogasawara H, Ikeda W, Kawano T, Imai T, Oyama N, Hasegawa M.

Arthritis Rheumatol. 2019 Jun 7. doi: 10.1002/art.41009. [Epub ahead of print]

PMID:
31173491
3.

Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time.

Motoi S, Toyoda H, Obara T, Ohta E, Arita Y, Negishi K, Moriya K, Kuboi Y, Soejima M, Imai T, Ido A, Tsubouchi H, Kawano T.

Int J Mol Sci. 2019 Apr 12;20(8). pii: E1821. doi: 10.3390/ijms20081821.

4.

Blockade of the fractalkine-CX3CR1 axis ameliorates experimental colitis by dislodging venous crawling monocytes.

Kuboi Y, Nishimura M, Ikeda W, Nakatani T, Seki Y, Yamaura Y, Ogawa K, Hamaguchi A, Muramoto K, Mizuno K, Ogasawara H, Yamauchi T, Yasuda N, Onodera H, Imai T.

Int Immunol. 2019 Apr 26;31(5):357. doi: 10.1093/intimm/dxz035. No abstract available.

PMID:
31002334
5.

Kras-driven heterotopic tumor development from hepatobiliary organoids.

Ochiai M, Yoshihara Y, Maru Y, Tetsuya M, Izumiya M, Imai T, Hippo Y.

Carcinogenesis. 2019 Feb 7. doi: 10.1093/carcin/bgz024. [Epub ahead of print]

PMID:
30753336
6.

GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.

Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K.

Nature. 2019 Feb;566(7742):110-114. doi: 10.1038/s41586-019-0884-1. Epub 2019 Jan 23.

PMID:
30675063
7.

Blockade of the fractalkine-CX3CR1 axis ameliorates experimental colitis by dislodging venous crawling monocytes.

Kuboi Y, Nishimura M, Ikeda W, Nakatani T, Seki Y, Yamaura Y, Ogawa K, Hamaguchi A, Muramoto K, Mizuno K, Ogasawara H, Yamauchi T, Yasuda N, Onodera H, Imai T.

Int Immunol. 2019 Apr 26;31(5):287-302. doi: 10.1093/intimm/dxz006.

PMID:
30668715
8.

Shortcuts to intestinal carcinogenesis by genetic engineering in organoids.

Maru Y, Onuma K, Ochiai M, Imai T, Hippo Y.

Cancer Sci. 2019 Mar;110(3):858-866. doi: 10.1111/cas.13938. Epub 2019 Feb 3. Review.

9.

Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study.

Tabuchi H, Katsurabara T, Mori M, Aoyama M, Obara T, Yasuda N, Kawano T, Imai T, Ieiri I, Kumagai Y.

J Clin Pharmacol. 2019 May;59(5):688-701. doi: 10.1002/jcph.1361. Epub 2018 Dec 21.

PMID:
30575978
10.

Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model.

Hattori N, Niwa T, Ishida T, Kobayashi K, Imai T, Mori A, Kimura K, Mori T, Asami Y, Ushijima T.

Cancer Sci. 2019 Jan;110(1):147-156. doi: 10.1111/cas.13880. Epub 2018 Dec 13.

11.

Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans.

Takahashi M, Hori M, Ishigamori R, Mutoh M, Imai T, Nakagama H.

Cancer Sci. 2018 Oct;109(10):3013-3023. doi: 10.1111/cas.13766. Epub 2018 Sep 5. Review.

12.

Role of Anti-Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis.

Hoshino-Negishi K, Ohkuro M, Nakatani T, Kuboi Y, Nishimura M, Ida Y, Kakuta J, Hamaguchi A, Kumai M, Kamisako T, Sugiyama F, Ikeda W, Ishii N, Yasuda N, Imai T.

Arthritis Rheumatol. 2019 Feb;71(2):222-231. doi: 10.1002/art.40688.

PMID:
30079992
13.

Activated Ductal Proliferation Induced by N-Nitrosobis (2-oxopropyl)amine in Fat-infiltrated Pancreas of KK-Ay Mice.

Hori M, Mutoh M, Ishigamori R, Imai T, Takahashi M.

In Vivo. 2018 May-Jun;32(3):499-505.

PMID:
29695552
14.

Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Sato H, Muraoka S, Kusunoki N, Masuoka S, Yamada S, Ogasawara H, Imai T, Akasaka Y, Tochigi N, Takahashi H, Tsuchiya K, Kawai S, Nanki T.

Arthritis Res Ther. 2017 Dec 1;19(1):263. doi: 10.1186/s13075-017-1472-0.

15.

E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis.

Wakita H, Yanagawa T, Kuboi Y, Imai T.

Mol Pharmacol. 2017 Nov;92(5):502-509. doi: 10.1124/mol.117.108381. Epub 2017 Aug 25.

PMID:
28842393
16.

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis.

Tanaka Y, Takeuchi T, Umehara H, Nanki T, Yasuda N, Tago F, Kawakubo M, Kitahara Y, Hojo S, Kawano T, Imai T.

Mod Rheumatol. 2018 Jan;28(1):58-65. doi: 10.1080/14397595.2017.1337056. Epub 2017 Jul 6.

PMID:
28681650
17.

Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.

Ishigamori R, Komiya M, Takasu S, Mutoh M, Imai T, Takahashi M.

Int J Mol Sci. 2017 May 14;18(5). pii: E1058. doi: 10.3390/ijms18051058.

18.

Imidazoline 1 receptor activation preserves respiratory drive in spontaneously breathing newborn rats during dexmedetomidine administration.

Sato N, Saiki C, Tamiya J, Imai T, Sunada K.

Paediatr Anaesth. 2017 May;27(5):506-515. doi: 10.1111/pan.13107. Epub 2017 Feb 8.

PMID:
28177562
19.

Horseradish extract promotes urinary bladder carcinogenesis when administered to F344 rats in drinking water.

Cho YM, Hasumura M, Imai T, Takami S, Nishikawa A, Ogawa K.

J Appl Toxicol. 2017 Jul;37(7):853-862. doi: 10.1002/jat.3434. Epub 2017 Feb 6.

PMID:
28165151
20.

Fractalkine/CX3CL1 in rheumatoid arthritis.

Nanki T, Imai T, Kawai S.

Mod Rheumatol. 2017 May;27(3):392-397. doi: 10.1080/14397595.2016.1213481. Epub 2016 Aug 2. Review.

PMID:
27484962

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