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Items: 1 to 20 of 130


Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques.

Sato E, Saigusa D, Mishima E, Uchida T, Miura D, Morikawa-Ichinose T, Kisu K, Sekimoto A, Saito R, Oe Y, Matsumoto Y, Tomioka Y, Mori T, Takahashi N, Sato H, Abe T, Niwa T, Ito S.

Toxins (Basel). 2017 Dec 28;10(1). pii: E19. doi: 10.3390/toxins10010019.


Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells.

Yisireyili M, Takeshita K, Saito S, Murohara T, Niwa T.

Nagoya J Med Sci. 2017 Nov;79(4):477-486. doi: 10.18999/nagjms.79.4.477.


Influence of AHRR Pro189Ala polymorphism on kidney functions.

Nakayama K, Saito S, Watanabe K, Miyashita H, Nishijima F, Kamo Y, Tada K, Ishizuka S, Niwa T, Iwamoto S, Shimizu H.

Biosci Biotechnol Biochem. 2017 Jun;81(6):1120-1124. doi: 10.1080/09168451.2017.1292838. Epub 2017 Feb 20.


Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice.

Yisireyili M, Hayashi M, Wu H, Uchida Y, Yamamoto K, Kikuchi R, Shoaib Hamrah M, Nakayama T, Wu Cheng X, Matsushita T, Nakamura S, Niwa T, Murohara T, Takeshita K.

Sci Rep. 2017 Apr 28;7(1):1266. doi: 10.1038/s41598-017-01366-3.


The role of carbon adsorbent in the conservative management of chronic kidney disease.

Niwa T.

Panminerva Med. 2017 Jun;59(2):139-148. doi: 10.23736/S0031-0808.16.03272-9. Epub 2016 Dec 16. Review.


Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease.

Sato E, Mori T, Mishima E, Suzuki A, Sugawara S, Kurasawa N, Saigusa D, Miura D, Morikawa-Ichinose T, Saito R, Oba-Yabana I, Oe Y, Kisu K, Naganuma E, Koizumi K, Mokudai T, Niwano Y, Kudo T, Suzuki C, Takahashi N, Sato H, Abe T, Niwa T, Ito S.

Sci Rep. 2016 Nov 10;6:36618. doi: 10.1038/srep36618.


Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population.

Goto A, Kotani H, Miyazaki M, Yamada K, Ishikawa K, Shimoyama Y, Niwa T, Hasegawa Y, Noda Y.

J Pharm Health Care Sci. 2016 Jul 21;2:16. doi: 10.1186/s40780-016-0049-4. eCollection 2016.


Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells.

Ng HY, Bolati W, Lee CT, Chien YS, Yisireyili M, Saito S, Pei SN, Nishijima F, Niwa T.

Nephron. 2016;133(3):205-12. doi: 10.1159/000447096. Epub 2016 Jun 25.


39th and 40th Annual Meetings of the Japanese Society for Biomedical Mass Spectrometry (JSBMS): New Applications of Mass Spectrometry in Biomedicine.

Nomura F, Setou M, Niwa T.

Anal Bioanal Chem. 2016 Nov;408(27):7545-7546. No abstract available.


Uremia research and toxicity.

Massry SG, Iseki K, Niwa T.

J Ren Nutr. 2015 Mar;25(2):144. doi: 10.1053/j.jrn.2014.11.003. No abstract available.


Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells.

Saito S, Yisireyili M, Shimizu H, Ng HY, Niwa T.

J Ren Nutr. 2015 Mar;25(2):145-8. doi: 10.1053/j.jrn.2014.10.008. Epub 2014 Dec 31.


Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-κB pathway.

Adelibieke Y, Yisireyili M, Ng HY, Saito S, Nishijima F, Niwa T.

Nephron Exp Nephrol. 2014;128(1-2):1-8. doi: 10.1159/000365217. Epub 2014 Nov 5.


Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells.

Yisireyili M, Saito S, Abudureyimu S, Adelibieke Y, Ng HY, Nishijima F, Takeshita K, Murohara T, Niwa T.

PLoS One. 2014 Oct 24;9(10):e109268. doi: 10.1371/journal.pone.0109268. eCollection 2014.


Polymorphisms of Nrf2, an antioxidative gene, are associated with blood pressure in Japanese.

Shimoyama Y, Mitsuda Y, Hamajima N, Niwa T.

Nagoya J Med Sci. 2014 Feb;76(1-2):113-20.


Plasma indoxyl sulfate and estimated glomerular filtration rate.

Yoshikawa D, Ishii H, Suzuki S, Takeshita K, Kumagai S, Hayashi M, Niwa T, Izawa H, Murohara T.

Circ J. 2014;78(10):2477-82. Epub 2014 Aug 11.


38th Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry (JSBMS): New Applications of Mass Spectrometry in Biomedicine.

Setou M, Niwa T, Igarashi K.

Anal Bioanal Chem. 2014 Sep;406(24):5749-50. doi: 10.1007/s00216-014-8009-z. No abstract available.


Polymorphism of Nrf2, an antioxidative gene, is associated with blood pressure and cardiovascular mortality in hemodialysis patients.

Shimoyama Y, Mitsuda Y, Tsuruta Y, Hamajima N, Niwa T.

Int J Med Sci. 2014 May 10;11(7):726-31. doi: 10.7150/ijms.8590. eCollection 2014.


Protein-bound molecules: a large family with a bad character.

Sirich TL, Meyer TW, Gondouin B, Brunet P, Niwa T.

Semin Nephrol. 2014 Mar;34(2):106-17. doi: 10.1016/j.semnephrol.2014.02.004. Epub 2014 Feb 18.


Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells.

Ng HY, Yisireyili M, Saito S, Lee CT, Adelibieke Y, Nishijima F, Niwa T.

PLoS One. 2014 Mar 10;9(3):e91517. doi: 10.1371/journal.pone.0091517. eCollection 2014.


Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.

Saito S, Shimizu H, Yisireyili M, Nishijima F, Enomoto A, Niwa T.

Endocrinology. 2014 May;155(5):1899-907. doi: 10.1210/en.2013-1937. Epub 2014 Mar 6.


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