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Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.

Indra R, Pompach P, Martínek V, Takácsová P, Vavrová K, Heger Z, Adam V, Eckschlager T, Kopečková K, Arlt VM, Stiborová M.

Int J Mol Sci. 2019 Jul 10;20(14). pii: E3392. doi: 10.3390/ijms20143392.

Free Article

Nanodrugs used in cancer therapy.

Kopeckova K, Eckschlager T, Sirc J, Hobzova R, Plch J, Hrabeta J, Michalek J.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019 Jun;163(2):122-131. doi: 10.5507/bp.2019.010. Epub 2019 Apr 9.


Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.

Indra R, Černá T, Heger Z, Hraběta J, Wilhelm M, Dostálová S, Lengálová A, Martínková M, Adam V, Eckschlager T, Schmeiser HH, Arlt VM, Stiborová M.

Toxicology. 2019 May 1;419:40-54. doi: 10.1016/j.tox.2019.03.009. Epub 2019 Mar 23.


Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine.

Strmiska V, Michalek P, Eckschlager T, Stiborova M, Adam V, Krizkova S, Heger Z.

Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):248-258. doi: 10.1016/j.bbcan.2019.01.001. Epub 2019 Jan 29. Review.


MicroRNA expression in pediatric intracranial ependymomas and their potential value for tumor grading.

Cipro Š, Belhajová M, Eckschlager T, Zámečník J.

Oncol Lett. 2019 Jan;17(1):1379-1383. doi: 10.3892/ol.2018.9685. Epub 2018 Nov 12.


Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis.

Strmiska V, Michalek P, Lackova Z, Guran R, Krizkova S, Vanickova L, Zitka O, Stiborova M, Eckschlager T, Klejdus B, Pacik D, Tvrdikova E, Keil C, Haase H, Adam V, Heger Z.

Mol Oncol. 2019 May;13(5):1002-1017. doi: 10.1002/1878-0261.12439. Epub 2019 Mar 9.


Folic acid-mediated re-shuttling of ferritin receptor specificity towards a selective delivery of highly cytotoxic nickel(II) coordination compounds.

Tesarova B, Charousova M, Dostalova S, Bienko A, Kopel P, Kruszyński R, Hynek D, Michalek P, Eckschlager T, Stiborova M, Adam V, Heger Z.

Int J Biol Macromol. 2019 Apr 1;126:1099-1111. doi: 10.1016/j.ijbiomac.2018.12.128. Epub 2018 Dec 31.


Proteomic Signature of Neuroblastoma Cells UKF-NB-4 Reveals Key Role of Lysosomal Sequestration and the Proteasome Complex in Acquiring Chemoresistance to Cisplatin.

Merlos Rodrigo MA, Buchtelova H, de Los Rios V, Casal JI, Eckschlager T, Hrabeta J, Belhajova M, Heger Z, Adam V.

J Proteome Res. 2019 Mar 1;18(3):1255-1263. doi: 10.1021/acs.jproteome.8b00867. Epub 2019 Jan 11.


KDM5 demethylases and their role in cancer cell chemoresistance.

Plch J, Hrabeta J, Eckschlager T.

Int J Cancer. 2019 Jan 15;144(2):221-231. doi: 10.1002/ijc.31881. Epub 2018 Nov 26. Review.


Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin.

Dostalova S, Polanska H, Svobodova M, Balvan J, Krystofova O, Haddad Y, Krizkova S, Masarik M, Eckschlager T, Stiborova M, Heger Z, Adam V.

Sci Rep. 2018 Jun 11;8(1):8867. doi: 10.1038/s41598-018-26772-z.


Paclitaxel-Loaded Polylactide/Polyethylene Glycol Fibers with Long-Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy.

Plch J, Venclikova K, Janouskova O, Hrabeta J, Eckschlager T, Kopeckova K, Hampejsova Z, Bosakova Z, Sirc J, Hobzova R.

Macromol Biosci. 2018 Jun;18(6):e1800011. doi: 10.1002/mabi.201800011. Epub 2018 Apr 24.


Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin.

Merlos Rodrigo MA, Dostalova S, Buchtelova H, Strmiska V, Michalek P, Krizkova S, Vicha A, Jencova P, Eckschlager T, Stiborova M, Heger Z, Adam V.

Oncotarget. 2017 Dec 16;9(4):4427-4439. doi: 10.18632/oncotarget.23333. eCollection 2018 Jan 12.


The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells.

Cerna T, Hrabeta J, Eckschlager T, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Int J Mol Sci. 2018 Jan 5;19(1). pii: E164. doi: 10.3390/ijms19010164.


Sarcosine influences apoptosis and growth of prostate cells via cell-type specific regulation of distinct sets of genes.

Rodrigo MAM, Strmiska V, Horackova E, Buchtelova H, Michalek P, Stiborova M, Eckschlager T, Adam V, Heger Z.

Prostate. 2018 Feb;78(2):104-112. doi: 10.1002/pros.23450. Epub 2017 Nov 6.


Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.

Stiborová M, Indra R, Frei E, Kopečková K, Schmeiser HH, Eckschlager T, Adam V, Heger Z, Arlt VM, Martínek V.

Monatsh Chem. 2017;148(11):1983-1991. doi: 10.1007/s00706-017-1986-9. Epub 2017 Jul 4.


An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena.

Krizkova S, Kepinska M, Emri G, Eckschlager T, Stiborova M, Pokorna P, Heger Z, Adam V.

Pharmacol Ther. 2018 Mar;183:90-117. doi: 10.1016/j.pharmthera.2017.10.004. Epub 2017 Oct 5. Review.


DNA interaction with platinum-based cytostatics revealed by DNA sequencing.

Smerkova K, Vaculovic T, Vaculovicova M, Kynicky J, Brtnicky M, Eckschlager T, Stiborova M, Hubalek J, Adam V.

Anal Biochem. 2017 Dec 15;539:22-28. doi: 10.1016/j.ab.2017.09.018. Epub 2017 Sep 29.


VPA does not enhance platinum binding to DNA in cisplatin-resistant neuroblastoma cancer cells.

Raudenska M, Krejcova L, Richtera L, Heger Z, Hrabeta J, Eckschlager T, Stiborova M, Adam V, Kratochvilova M, Masarik M, Gumulec J.

Tumour Biol. 2017 Sep;39(9):1010428317711656. doi: 10.1177/1010428317711656.


Histone Deacetylase Inhibitors as Anticancer Drugs.

Eckschlager T, Plch J, Stiborova M, Hrabeta J.

Int J Mol Sci. 2017 Jul 1;18(7). pii: E1414. doi: 10.3390/ijms18071414. Review.


Apoferritin as an ubiquitous nanocarrier with excellent shelf life.

Dostalova S, Vasickova K, Hynek D, Krizkova S, Richtera L, Vaculovicova M, Eckschlager T, Stiborova M, Heger Z, Adam V.

Int J Nanomedicine. 2017 Mar 24;12:2265-2278. doi: 10.2147/IJN.S130267. eCollection 2017.

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