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Items: 1 to 20 of 98

1.

Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization.

Randárová E, Nakamura H, Islam R, Studenovský M, Mamoru H, Fang J, Chytil P, Etrych T.

Acta Biomater. 2020 Feb 11. pii: S1742-7061(20)30090-8. doi: 10.1016/j.actbio.2020.02.011. [Epub ahead of print]

PMID:
32058082
2.

HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours.

Kostka L, Kotrchová L, Šubr V, Libánská A, Ferreira CA, Malátová I, Lee HJ, Barnhart TE, Engle JW, Cai W, Šírová M, Etrych T.

Biomaterials. 2020 Mar;235:119728. doi: 10.1016/j.biomaterials.2019.119728. Epub 2019 Dec 26.

PMID:
32044514
3.

Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins.

Janisova L, Gruzinov A, Zaborova OV, Velychkivska N, Vaněk O, Chytil P, Etrych T, Janoušková O, Zhang X, Blanchet C, Papadakis CM, Svergun DI, Filippov SK.

Pharmaceutics. 2020 Jan 28;12(2). pii: E106. doi: 10.3390/pharmaceutics12020106.

4.

Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length.

Böhmová E, Pola R, Pechar M, Parnica J, Machová D, Janoušková O, Etrych T.

Pharmaceutics. 2020 Jan 10;12(1). pii: E59. doi: 10.3390/pharmaceutics12010059.

5.

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors.

Pola R, Böhmová E, Filipová M, Pechar M, Pankrác J, Větvička D, Olejár T, Kabešová M, Poučková P, Šefc L, Zábrodský M, Janoušková O, Bouček J, Etrych T.

Pharmaceutics. 2020 Jan 1;12(1). pii: E31. doi: 10.3390/pharmaceutics12010031.

6.

High-Affinity N-(2-Hydroxypropyl)methacrylamide Copolymers with Tailored N-Acetyllactosamine Presentation Discriminate between Galectins.

Tavares MR, Bláhová M, Sedláková L, Elling L, Pelantová H, Konefał R, Etrych T, Křen V, Bojarová P, Chytil P.

Biomacromolecules. 2020 Feb 10;21(2):641-652. doi: 10.1021/acs.biomac.9b01370. Epub 2020 Jan 23.

PMID:
31904940
7.

Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship.

Braunová A, Kaňa M, Kudláčová J, Kostka L, Bouček J, Betka J, Šírová M, Etrych T.

Pharmaceutics. 2019 Nov 5;11(11). pii: E579. doi: 10.3390/pharmaceutics11110579.

8.

Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery.

Kunjachan S, Kotb S, Pola R, Pechar M, Kumar R, Singh B, Gremse F, Taleeli R, Trichard F, Motto-Ros V, Sancey L, Detappe A, Yasmin-Karim S, Protti A, Shanmugam I, Ireland T, Etrych T, Sridhar S, Tillement O, Makrigiorgos M, Berbeco RI.

Sci Rep. 2019 Nov 1;9(1):15844. doi: 10.1038/s41598-019-50538-w.

9.

Fluorescence Imaging as a Tool in Preclinical Evaluation of Polymer-Based Nano-DDS Systems Intended for Cancer Treatment.

Etrych T, Janoušková O, Chytil P.

Pharmaceutics. 2019 Sep 12;11(9). pii: E471. doi: 10.3390/pharmaceutics11090471. Review.

10.

In memory of Karel Ulbrich.

Etrych T.

J Control Release. 2019 Sep 10;309:343. doi: 10.1016/j.jconrel.2019.08.013. Epub 2019 Aug 14. No abstract available.

PMID:
31421158
11.

Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents.

Fang J, Islam R, Islam W, Yin H, Subr V, Etrych T, Ulbrich K, Maeda H.

Pharmaceutics. 2019 Jul 16;11(7). pii: E343. doi: 10.3390/pharmaceutics11070343.

12.

Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid.

Nakamura H, Koziolová E, Chytil P, Etrych T, Haratake M, Maeda H.

Mol Pharm. 2019 Aug 5;16(8):3452-3459. doi: 10.1021/acs.molpharmaceut.9b00248. Epub 2019 Jul 11.

PMID:
31294568
13.

Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors.

Hackbarth S, Islam W, Fang J, Šubr V, Röder B, Etrych T, Maeda H.

Photochem Photobiol Sci. 2019 Jun 12;18(6):1304-1314. doi: 10.1039/c8pp00570b.

PMID:
30994640
14.

Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction.

Lynn GM, Chytil P, Francica JR, Lagová A, Kueberuwa G, Ishizuka AS, Zaidi N, Ramirez-Valdez RA, Blobel NJ, Baharom F, Leal J, Wang AQ, Gerner MY, Etrych T, Ulbrich K, Seymour LW, Seder RA, Laga R.

Biomacromolecules. 2019 Feb 11;20(2):854-870. doi: 10.1021/acs.biomac.8b01473. Epub 2019 Jan 22.

PMID:
30608149
15.

Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells.

Pola R, Král V, Filippov SK, Kaberov L, Etrych T, Sieglová I, Sedláček J, Fábry M, Pechar M.

Biomacromolecules. 2019 Jan 14;20(1):412-421. doi: 10.1021/acs.biomac.8b01616. Epub 2018 Dec 7.

PMID:
30485077
16.

Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging.

Etrych T, Daumová L, Pokorná E, Tušková D, Lidický O, Kolářová V, Pankrác J, Šefc L, Chytil P, Klener P.

J Control Release. 2018 Nov 10;289:44-55. doi: 10.1016/j.jconrel.2018.09.018. Epub 2018 Sep 22.

PMID:
30248447
17.

Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines.

Islam W, Fang J, Imamura T, Etrych T, Subr V, Ulbrich K, Maeda H.

Mol Cancer Ther. 2018 Dec;17(12):2643-2653. doi: 10.1158/1535-7163.MCT-18-0696. Epub 2018 Sep 19.

18.

N-(2-Hydroxypropyl)methacrylamide-Based Linear, Diblock, and Starlike Polymer Drug Carriers: Advanced Process for Their Simple Production.

Koziolová E, Kostka L, Kotrchová L, Šubr V, Konefal R, Nottelet B, Etrych T.

Biomacromolecules. 2018 Oct 8;19(10):4003-4013. doi: 10.1021/acs.biomac.8b00973. Epub 2018 Sep 19.

PMID:
30180562
19.

Nanotherapeutics with suitable properties for advanced anticancer therapy based on HPMA copolymer-bound ritonavir via pH-sensitive spacers.

Machová D, Koziolová E, Chytil P, Venclíková K, Etrych T, Janoušková O.

Eur J Pharm Biopharm. 2018 Oct;131:141-150. doi: 10.1016/j.ejpb.2018.07.023. Epub 2018 Jul 31.

PMID:
30075311
20.

Binding of HSA to Macromolecular pHPMA Based Nanoparticles for Drug Delivery: An Investigation Using Fluorescence Methods.

Zhang X, Chytil P, Etrych T, Liu W, Rodrigues L, Winter G, Filippov SK, Papadakis CM.

Langmuir. 2018 Jul 10;34(27):7998-8006. doi: 10.1021/acs.langmuir.8b01015. Epub 2018 Jun 27.

PMID:
29949376

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