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Items: 1 to 20 of 34

1.

The Function of Lgr5+ Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo.

Flanagan D, Barker N, Ernst M, Vincan E, Phesse T.

Biomedicines. 2019 Jul 8;7(3). pii: E50. doi: 10.3390/biomedicines7030050.

2.

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.

Eissmann MF, Dijkstra C, Jarnicki A, Phesse T, Brunnberg J, Poh AR, Etemadi N, Tsantikos E, Thiem S, Huntington ND, Hibbs ML, Boussioutas A, Grimbaldeston MA, Buchert M, O'Donoghue RJJ, Masson F, Ernst M.

Nat Commun. 2019 Jun 21;10(1):2735. doi: 10.1038/s41467-019-10676-1.

3.

Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations.

Flanagan DJ, Barker N, Costanzo NSD, Mason EA, Gurney A, Meniel VS, Koushyar S, Austin CR, Ernst M, Pearson HB, Boussioutas A, Clevers H, Phesse TJ, Vincan E.

Cancer Res. 2019 Mar 1;79(5):970-981. doi: 10.1158/0008-5472.CAN-18-2095. Epub 2019 Jan 8.

PMID:
30622113
4.

Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis.

Greenow KR, Zverev M, May S, Kendrick H, Williams GT, Phesse T, Parry L.

Oncotarget. 2018 Nov 23;9(92):36430-36443. doi: 10.18632/oncotarget.26335. eCollection 2018 Nov 23.

5.

Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc".

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, Moreno de Alboran I, Clevers H, Clarke AR.

Mol Cell Biol. 2018 Nov 28;38(24). pii: e00482-18. doi: 10.1128/MCB.00482-18. Print 2018 Dec 15. No abstract available.

6.

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

May S, Owen H, Phesse TJ, Greenow KR, Jones GR, Blackwood A, Cook PC, Towers C, Gallimore AM, Williams GT, Stürzl M, Britzen-Laurent N, Sansom OJ, MacDonald AS, Bird AP, Clarke AR, Parry L.

J Pathol. 2018 Jul;245(3):270-282. doi: 10.1002/path.5074. Epub 2018 May 16.

7.

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26.

8.

Wnt Signalling in Gastrointestinal Epithelial Stem Cells.

Flanagan DJ, Austin CR, Vincan E, Phesse TJ.

Genes (Basel). 2018 Mar 23;9(4). pii: E178. doi: 10.3390/genes9040178. Review.

9.

The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy.

Vincan E, Schwab RHM, Flanagan DJ, Moselen JM, Tran BM, Barker N, Phesse TJ.

Prog Mol Biol Transl Sci. 2018 Jan;153:299-319. doi: 10.1016/bs.pmbts.2017.11.009. Epub 2017 Dec 21. Review.

PMID:
29389521
10.

Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models.

Phesse TJ, Durban VM, Sansom OJ.

Carcinogenesis. 2017 Oct 1;38(10):953-965. doi: 10.1093/carcin/bgx080. Review.

11.

Lgr5 joins the club of gastric stem cell markers in the corpus.

Phesse TJ, Sansom OJ.

Nat Cell Biol. 2017 Jun 29;19(7):752-754. doi: 10.1038/ncb3567.

PMID:
28659641
12.

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.

Flanagan DJ, Barker N, Nowell C, Clevers H, Ernst M, Phesse TJ, Vincan E.

Dis Model Mech. 2017 Aug 1;10(8):971-980. doi: 10.1242/dmm.029876. Epub 2017 Jun 9.

13.

Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers.

Flanagan DJ, Vincan E, Phesse TJ.

Br J Pharmacol. 2017 Dec;174(24):4666-4683. doi: 10.1111/bph.13890. Epub 2017 Jul 5. Review.

14.

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.

Schwab RHM, Amin N, Flanagan DJ, Johanson TM, Phesse TJ, Vincan E.

Dev Dyn. 2018 Mar;247(3):521-530. doi: 10.1002/dvdy.24527. Epub 2017 Jun 22.

15.

Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion.

Flanagan DJ, Schwab RH, Tran BM, Phesse TJ, Vincan E.

Methods Mol Biol. 2016 Oct 5. [Epub ahead of print]

PMID:
27704362
16.

Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer.

Phesse T, Flanagan D, Vincan E.

Cancers (Basel). 2016 May 17;8(5). pii: E50. doi: 10.3390/cancers8050050. Review.

17.

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

Tögel L, Nightingale R, Chueh AC, Jayachandran A, Tran H, Phesse T, Wu R, Sieber OM, Arango D, Dhillon AS, Dawson MA, Diez-Dacal B, Gahman TC, Filippakopoulos P, Shiau AK, Mariadason JM.

Mol Cancer Ther. 2016 Jun;15(6):1217-26. doi: 10.1158/1535-7163.MCT-15-0724. Epub 2016 Mar 16.

18.

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.

Pearson HB, McGlinn E, Phesse TJ, Schlüter H, Srikumar A, Gödde NJ, Woelwer CB, Ryan A, Phillips WA, Ernst M, Kaur P, Humbert P.

Mol Cancer. 2015 Sep 17;14:169. doi: 10.1186/s12943-015-0440-z.

19.

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E.

Stem Cell Reports. 2015 May 12;4(5):759-67. doi: 10.1016/j.stemcr.2015.03.003. Epub 2015 Apr 16.

20.

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M.

Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411.

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