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Items: 1 to 20 of 33


Analysis of AgoshRNA maturation and loading into Ago2.

Harwig A, Kruize Z, Yang Z, Restle T, Berkhout B.

PLoS One. 2017 Aug 15;12(8):e0183269. doi: 10.1371/journal.pone.0183269. eCollection 2017.


Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.

Willkomm S, Oellig CA, Zander A, Restle T, Keegan R, Grohmann D, Schneider S.

Nat Microbiol. 2017 Mar 20;2:17035. doi: 10.1038/nmicrobiol.2017.35.


Kinetic Analysis of Target RNA Binding and Slicing by Human Argonaute 2 Protein.

Willkomm S, Restle T.

Methods Mol Biol. 2017;1517:277-290.


Mechanistic Insights into Archaeal and Human Argonaute Substrate Binding and Cleavage Properties.

Willkomm S, Zander A, Grohmann D, Restle T.

PLoS One. 2016 Oct 14;11(10):e0164695. doi: 10.1371/journal.pone.0164695. eCollection 2016.


Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease.

Gupta Y, Möller S, Witte M, Belheouane M, Sezin T, Hirose M, Vorobyev A, Niesar F, Bischof J, Ludwig RJ, Zillikens D, Sadik CD, Restle T, Häsler R, Baines JF, Ibrahim SM.

BMC Genomics. 2016 Feb 16;17:112. doi: 10.1186/s12864-016-2455-2.


Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro.

Willkomm S, Deerberg A, Heidemann J, Flügge F, Meine J, Hu R, Kretschmer-Kazemi Far R, Restle T.

PLoS One. 2016 Jan 19;11(1):e0146814. doi: 10.1371/journal.pone.0146814. eCollection 2016.


FRET-based assay to screen inhibitors of HIV-1 reverse transcriptase and nucleocapsid protein.

Sharma KK, Przybilla F, Restle T, Godet J, Mély Y.

Nucleic Acids Res. 2016 May 5;44(8):e74. doi: 10.1093/nar/gkv1532. Epub 2016 Jan 13.


Novel Insights into Guide RNA 5'-Nucleoside/Tide Binding by Human Argonaute 2.

Kalia M, Willkomm S, Claussen JC, Restle T, Bonvin AM.

Int J Mol Sci. 2015 Dec 24;17(1). pii: E22. doi: 10.3390/ijms17010022.


RNAi revised--target mRNA-dependent enhancement of gene silencing.

Dornseifer S, Willkomm S, Far RK, Liebschwager J, Beltsiou F, Frank K, Laufer SD, Martinetz T, Sczakiel G, Claussen JC, Restle T.

Nucleic Acids Res. 2015 Dec 15;43(22):10623-32. doi: 10.1093/nar/gkv1200. Epub 2015 Nov 17.


Conformational Dynamics of Ago-Mediated Silencing Processes.

Willkomm S, Restle T.

Int J Mol Sci. 2015 Jul 1;16(7):14769-85. doi: 10.3390/ijms160714769. Review.


ptRNApred: computational identification and classification of post-transcriptional RNA.

Gupta Y, Witte M, Möller S, Ludwig RJ, Restle T, Zillikens D, Ibrahim SM.

Nucleic Acids Res. 2014 Dec 16;42(22):e167. doi: 10.1093/nar/gku918. Epub 2014 Oct 10.


Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein.

Deerberg A, Willkomm S, Restle T.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17850-5. doi: 10.1073/pnas.1217838110. Epub 2013 Oct 7.


A toolkit and benchmark study for FRET-restrained high-precision structural modeling.

Kalinin S, Peulen T, Sindbert S, Rothwell PJ, Berger S, Restle T, Goody RS, Gohlke H, Seidel CA.

Nat Methods. 2012 Dec;9(12):1218-25. doi: 10.1038/nmeth.2222. Epub 2012 Nov 11.


A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

Lyonnais S, Gorelick RJ, Heniche-Boukhalfa F, Bouaziz S, Parissi V, Mouscadet JF, Restle T, Gatell JM, Le Cam E, Mirambeau G.

Virus Res. 2013 Feb;171(2):287-303. doi: 10.1016/j.virusres.2012.09.008. Epub 2012 Sep 24.


Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity.

Xiao Y, Ma Q, Restle T, Shang W, Svergun DI, Ponnusamy R, Sczakiel G, Hilgenfeld R.

J Virol. 2012 Apr;86(8):4444-54. doi: 10.1128/JVI.06635-11. Epub 2012 Feb 8.


Oligomeric nucleic acids as antivirals.

Mescalchin A, Restle T.

Molecules. 2011 Jan 28;16(2):1271-96. doi: 10.3390/molecules16021271. Review.


Recent developments in peptide-based nucleic acid delivery.

Veldhoen S, Laufer SD, Restle T.

Int J Mol Sci. 2008 Jun;9(7):1276-320. doi: 10.3390/ijms9071276. Epub 2008 Jul 16.


Noncovalent peptide-mediated delivery of chemically modified steric block oligonucleotides promotes splice correction: quantitative analysis of uptake and biological effect.

Laufer SD, Recke AL, Veldhoen S, Trampe A, Restle T.

Oligonucleotides. 2009 Mar;19(1):63-80. doi: 10.1089/oli.2008.0160.


HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates.

Grohmann D, Godet J, Mély Y, Darlix JL, Restle T.

Biochemistry. 2008 Nov 18;47(46):12230-40. doi: 10.1021/bi801386r. Epub 2008 Oct 24.


Opposed steric constraints in human DNA polymerase beta and E. coli DNA polymerase I.

Di Pasquale F, Fischer D, Grohmann D, Restle T, Geyer A, Marx A.

J Am Chem Soc. 2008 Aug 13;130(32):10748-57. doi: 10.1021/ja8028284. Epub 2008 Jul 16.


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