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Items: 1 to 20 of 89


Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells.

Janitschke D, Nelke C, Lauer AA, Regner L, Winkler J, Thiel A, Grimm HS, Hartmann T, Grimm MOW.

Biomolecules. 2019 Nov 2;9(11). pii: E689. doi: 10.3390/biom9110689.


A novel and highly efficient purification procedure for native human dipeptidyl peptidase 3 from human blood cell lysate.

Kaufmann P, Muenzner M, Kästorf M, Santos K, Hartmann T, Dienelt A, Rehfeld L, Bergmann A.

PLoS One. 2019 Aug 7;14(8):e0220866. doi: 10.1371/journal.pone.0220866. eCollection 2019.


Using joint models to disentangle intervention effect types and baseline confounding: an application within an intervention study in prodromal Alzheimer's disease with Fortasyn Connect.

van Oudenhoven FM, Swinkels SHN, Hartmann T, Soininen H, van Hees AMJ, Rizopoulos D.

BMC Med Res Methodol. 2019 Jul 25;19(1):163. doi: 10.1186/s12874-019-0791-z.


Profiling of Alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis.

Grimm MOW, Lauer AA, Grösgen S, Thiel A, Lehmann J, Winkler J, Janitschke D, Herr C, Beisswenger C, Bals R, Grimm HS, Hartmann T.

J Nutr Biochem. 2019 May;67:123-137. doi: 10.1016/j.jnutbio.2019.01.015. Epub 2019 Feb 11.


Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.

Reinhardt S, Schuck F, Stoye N, Hartmann T, Grimm MOW, Pflugfelder G, Endres K.

Cell Mol Life Sci. 2019 Mar;76(5):1005-1025. doi: 10.1007/s00018-018-2998-2. Epub 2019 Jan 1.


Older Adults' Reasons for Participating in an eHealth Prevention Trial: A Cross-Country, Mixed-Methods Comparison.

Coley N, Rosenberg A, van Middelaar T, Soulier A, Barbera M, Guillemont J, Steensma J, Igier V, Eskelinen M, Soininen H, Moll van Charante E, Richard E, Kivipelto M, Andrieu S; MIND-AD; HATICE groups.

J Am Med Dir Assoc. 2019 Jul;20(7):843-849.e5. doi: 10.1016/j.jamda.2018.10.019. Epub 2018 Dec 9.


Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model.

Verheijen BM, Stevens JAA, Gentier RJG, van 't Hekke CD, van den Hove DLA, Hermes DJHP, Steinbusch HWM, Ruijter JM, Grimm MOW, Haupenthal VJ, Annaert W, Hartmann T, van Leeuwen FW.

Neurobiol Aging. 2018 Dec;72:62-71. doi: 10.1016/j.neurobiolaging.2018.08.011. Epub 2018 Aug 18.


Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion.

Barbero-Camps E, Roca-Agujetas V, Bartolessis I, de Dios C, Fernández-Checa JC, Marí M, Morales A, Hartmann T, Colell A.

Autophagy. 2018;14(7):1129-1154. doi: 10.1080/15548627.2018.1438807. Epub 2018 Jun 4.


World Wide Fingers will advance dementia prevention.

Kivipelto M, Mangialasche F, Ngandu T; World Wide Fingers Network.

Lancet Neurol. 2018 Jan;17(1):27. doi: 10.1016/S1474-4422(17)30431-3. Epub 2017 Dec 16. No abstract available.


Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.

Grimm MOW, Thiel A, Lauer AA, Winkler J, Lehmann J, Regner L, Nelke C, Janitschke D, Benoist C, Streidenberger O, Stötzel H, Endres K, Herr C, Beisswenger C, Grimm HS, Bals R, Lammert F, Hartmann T.

Int J Mol Sci. 2017 Dec 19;18(12). pii: E2764. doi: 10.3390/ijms18122764.


24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial.

Soininen H, Solomon A, Visser PJ, Hendrix SB, Blennow K, Kivipelto M, Hartmann T; LipiDiDiet clinical study group.

Lancet Neurol. 2017 Dec;16(12):965-975. doi: 10.1016/S1474-4422(17)30332-0. Epub 2017 Oct 30.


Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.

Grimm MOW, Michaelson DM, Hartmann T.

J Lipid Res. 2017 Nov;58(11):2083-2101. doi: 10.1194/jlr.R076331. Epub 2017 May 20. Review.


APP Function and Lipids: A Bidirectional Link.

Grimm MO, Mett J, Grimm HS, Hartmann T.

Front Mol Neurosci. 2017 Mar 10;10:63. doi: 10.3389/fnmol.2017.00063. eCollection 2017. Review.


Radioiodine therapy of benign thyroid-disorders.

Hartmann T, Vach W, Frings L, Mix M, Meyer PT, Ruf J.

Nuklearmedizin. 2017;56(5):171-176. doi: 10.3413/Nukmed-0875-17-01. Epub 2018 Jan 4.


Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model.

Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A, Endres K.

J Alzheimers Dis. 2017;56(2):775-788. doi: 10.3233/JAD-160926.


Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme.

Grimm MO, Mett J, Stahlmann CP, Haupenthal VJ, Blümel T, Stötzel H, Grimm HS, Hartmann T.

Biochem Cell Biol. 2016 Dec;94(6):534-542. Epub 2016 Apr 4.


Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease.

Grimm MO, Regner L, Mett J, Stahlmann CP, Schorr P, Nelke C, Streidenberger O, Stoetzel H, Winkler J, Zaidan SR, Thiel A, Endres K, Grimm HS, Volmer DA, Hartmann T.

Int J Mol Sci. 2016 Oct 29;17(11). pii: E1809.


The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease.

Grimm MO, Mett J, Hartmann T.

Int J Mol Sci. 2016 Oct 26;17(11). pii: E1785. Review.


Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice.

Wittmann A, Grimm MO, Scherthan H, Horsch M, Beckers J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Ford SJ, Burton NC, Razansky D, Trümbach D, Aichler M, Walch AK, Calzada-Wack J, Neff F, Wurst W, Hartmann T, Floss T.

PLoS One. 2016 Oct 27;11(10):e0164298. doi: 10.1371/journal.pone.0164298. eCollection 2016.


Transnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice.

Endres K, Reinhardt S, Geladaris A, Knies J, Grimm M, Hartmann T, Schmitt U.

BMC Neurosci. 2016 Jul 4;17(1):44. doi: 10.1186/s12868-016-0280-9.

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