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Items: 1 to 20 of 33


β- N-methylamino-L-alanine Inhibits Human Catalase Activity: Possible Implications for Neurodegenerative Disease Development.

van Onselen R, Downing TG.

Int J Toxicol. 2019 Jan 20:1091581818821921. doi: 10.1177/1091581818821921. [Epub ahead of print]


Potential for dietary exposure to β-N-methylamino-L-alanine and microcystin from a freshwater system.

Scott LL, Downing S, Downing T.

Toxicon. 2018 Aug;150:261-266. doi: 10.1016/j.toxicon.2018.06.076. Epub 2018 Jun 18.


Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus.

Coughlan S, Taylor AS, Feane E, Sanders M, Schonian G, Cotton JA, Downing T.

R Soc Open Sci. 2018 Apr 25;5(4):172212. doi: 10.1098/rsos.172212. eCollection 2018 Apr.


Development and Evaluation of a Novel Loop-Mediated Isothermal Amplification Assay for Diagnosis of Cutaneous and Visceral Leishmaniasis.

Adams ER, Schoone G, Versteeg I, Gomez MA, Diro E, Mori Y, Perlee D, Downing T, Saravia N, Assaye A, Hailu A, Albertini A, Ndung'u JM, Schallig H.

J Clin Microbiol. 2018 Jun 25;56(7). pii: e00386-18. doi: 10.1128/JCM.00386-18. Print 2018 Jul.


Investigating β-N-Methylamino-l-alanine Misincorporation in Human Cell Cultures: A Comparative Study with Known Amino Acid Analogues.

Onselen RV, Downing S, Kemp G, Downing T.

Toxins (Basel). 2017 Dec 14;9(12). pii: E400. doi: 10.3390/toxins9120400.


Tandem Amplification of the Staphylococcal Cassette Chromosome mec Element Can Drive High-Level Methicillin Resistance in Methicillin-Resistant Staphylococcus aureus.

Gallagher LA, Coughlan S, Black NS, Lalor P, Waters EM, Wee B, Watson M, Downing T, Fitzgerald JR, Fleming GTA, O'Gara JP.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00869-17. doi: 10.1128/AAC.00869-17. Print 2017 Sep.


The genome of Leishmania adleri from a mammalian host highlights chromosome fission in Sauroleishmania.

Coughlan S, Mulhair P, Sanders M, Schonian G, Cotton JA, Downing T.

Sci Rep. 2017 Mar 3;7:43747. doi: 10.1038/srep43747.


Leishmania infections: Molecular targets and diagnosis.

Akhoundi M, Downing T, Votýpka J, Kuhls K, Lukeš J, Cannet A, Ravel C, Marty P, Delaunay P, Kasbari M, Granouillac B, Gradoni L, Sereno D.

Mol Aspects Med. 2017 Oct;57:1-29. doi: 10.1016/j.mam.2016.11.012. Epub 2017 Jan 31. Review.


Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections.

Waters EM, Rudkin JK, Coughlan S, Clair GC, Adkins JN, Gore S, Xia G, Black NS, Downing T, O'Neill E, Kadioglu A, O'Gara JP.

J Infect Dis. 2017 Jan 1;215(1):80-87. doi: 10.1093/infdis/jiw461. Epub 2016 Nov 14.


A Polynucleotide Repeat Expansion Causing Temperature-Sensitivity Persists in Wild Irish Accessions of Arabidopsis thaliana.

Tabib A, Vishwanathan S, Seleznev A, McKeown PC, Downing T, Dent C, Sanchez-Bermejo E, Colling L, Spillane C, Balasubramanian S.

Front Plant Sci. 2016 Aug 31;7:1311. doi: 10.3389/fpls.2016.01311. eCollection 2016.


Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.

Imamura H, Downing T, Van den Broeck F, Sanders MJ, Rijal S, Sundar S, Mannaert A, Vanaerschot M, Berg M, De Muylder G, Dumetz F, Cuypers B, Maes I, Domagalska M, Decuypere S, Rai K, Uranw S, Bhattarai NR, Khanal B, Prajapati VK, Sharma S, Stark O, Schönian G, De Koning HP, Settimo L, Vanhollebeke B, Roy S, Ostyn B, Boelaert M, Maes L, Berriman M, Dujardin JC, Cotton JA.

Elife. 2016 Mar 22;5. pii: e12613. doi: 10.7554/eLife.12613.


The triploid East African Highland Banana (EAHB) genepool is genetically uniform arising from a single ancestral clone that underwent population expansion by vegetative propagation.

Kitavi M, Downing T, Lorenzen J, Karamura D, Onyango M, Nyine M, Ferguson M, Spillane C.

Theor Appl Genet. 2016 Mar;129(3):547-61. doi: 10.1007/s00122-015-2647-1. Epub 2016 Jan 8.


Cross Platform Standardisation of an Experimental Pipeline for Use in the Identification of Dysregulated Human Circulating MiRNAs.

Kelly H, Downing T, Tuite NL, Smith TJ, Kerin MJ, Dwyer RM, Clancy E, Barry T, Reddington K.

PLoS One. 2015 Sep 10;10(9):e0137389. doi: 10.1371/journal.pone.0137389. eCollection 2015.


Bacteria do not incorporate β-N-methylamino-L-alanine into their proteins.

van Onselen R, Cook NA, Phelan RR, Downing TG.

Toxicon. 2015 Aug;102:55-61. doi: 10.1016/j.toxicon.2015.05.014. Epub 2015 Jun 4.


β-N-methylamino-L-alanine (BMAA) uptake by the animal model, Daphnia magna and subsequent oxidative stress.

Esterhuizen-Londt M, Wiegand C, Downing TG.

Toxicon. 2015 Jun 15;100:20-6. doi: 10.1016/j.toxicon.2015.03.021. Epub 2015 Apr 1.


Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population.

Rogers MB, Downing T, Smith BA, Imamura H, Sanders M, Svobodova M, Volf P, Berriman M, Cotton JA, Smith DF.

PLoS Genet. 2014 Jan;10(1):e1004092. doi: 10.1371/journal.pgen.1004092. Epub 2014 Jan 16.


Genome-wide association analysis of avian resistance to Campylobacter jejuni colonization identifies risk locus spanning the CDH13 gene.

Connell S, Meade KG, Allan B, Lloyd AT, Downing T, O'Farrelly C, Bradley DG.

G3 (Bethesda). 2013 May 20;3(5):881-90. doi: 10.1534/g3.113.006031.


Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania.

Mannaert A, Downing T, Imamura H, Dujardin JC.

Trends Parasitol. 2012 Sep;28(9):370-6. doi: 10.1016/ Epub 2012 Jul 11. Review.


Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.

Vanaerschot M, Decuypere S, Downing T, Imamura H, Stark O, De Doncker S, Roy S, Ostyn B, Maes L, Khanal B, Boelaert M, Schönian G, Berriman M, Chappuis F, Dujardin JC, Sundar S, Rijal S.

J Infect Dis. 2012 Sep 1;206(5):752-5. doi: 10.1093/infdis/jis424. Epub 2012 Jun 29.

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