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Items: 1 to 20 of 56

1.

Structure-based characterization of novel TRPV5 inhibitors.

Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC 3rd, Filizola M, Rohacs T, Moiseenkova-Bell VY.

Elife. 2019 Oct 25;8. pii: e49572. doi: 10.7554/eLife.49572.

2.

Molecular mechanism of TRPV2 channel modulation by cannabidiol.

Pumroy RA, Samanta A, Liu Y, Hughes TE, Zhao S, Yudin Y, Rohacs T, Han S, Moiseenkova-Bell VY.

Elife. 2019 Sep 30;8. pii: e48792. doi: 10.7554/eLife.48792.

3.

G αq Sensitizes TRPM8 to Inhibition by PI(4,5)P2 Depletion upon Receptor Activation.

Liu L, Yudin Y, Nagwekar J, Kang C, Shirokova N, Rohacs T.

J Neurosci. 2019 Jul 31;39(31):6067-6080. doi: 10.1523/JNEUROSCI.2304-18.2019. Epub 2019 May 24.

PMID:
31127000
4.

The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels.

Yudin Y, Rohacs T.

Br J Pharmacol. 2019 Sep;176(17):3110-3125. doi: 10.1111/bph.14702. Epub 2019 Jul 9.

PMID:
31074038
5.

Tools for Understanding Nanoscale Lipid Regulation of Ion Channels.

Robinson CV, Rohacs T, Hansen SB.

Trends Biochem Sci. 2019 Sep;44(9):795-806. doi: 10.1016/j.tibs.2019.04.001. Epub 2019 May 3. Review.

PMID:
31060927
6.

A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine.

Kasimova MA, Yazici AT, Yudin Y, Granata D, Klein ML, Rohacs T, Carnevale V.

J Gen Physiol. 2018 Nov 5;150(11):1554-1566. doi: 10.1085/jgp.201812124. Epub 2018 Oct 17.

7.

Structural insights on TRPV5 gating by endogenous modulators.

Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY.

Nat Commun. 2018 Oct 10;9(1):4198. doi: 10.1038/s41467-018-06753-6.

8.

Inhibitory Gi/O-coupled receptors in somatosensory neurons: Potential therapeutic targets for novel analgesics.

Yudin Y, Rohacs T.

Mol Pain. 2018 Jan-Dec;14:1744806918763646. doi: 10.1177/1744806918763646. Review.

9.

Ion Channel Sensing: Are Fluctuations the Crux of the Matter?

Kasimova MA, Yazici A, Yudin Y, Granata D, Klein ML, Rohacs T, Carnevale V.

J Phys Chem Lett. 2018 Mar 15;9(6):1260-1264. doi: 10.1021/acs.jpclett.7b03396. Epub 2018 Feb 27.

10.

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.

Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY.

Nat Struct Mol Biol. 2018 Jan;25(1):53-60. doi: 10.1038/s41594-017-0009-1. Epub 2018 Jan 1.

11.

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits.

Badheka D, Yudin Y, Borbiro I, Hartle CM, Yazici A, Mirshahi T, Rohacs T.

Elife. 2017 Aug 15;6. pii: e26147. doi: 10.7554/eLife.26147.

12.

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.

Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K.

Nat Med. 2017 Apr;23(4):429-438. doi: 10.1038/nm.4287. Epub 2017 Feb 20.

13.

TRPV1: A Target for Rational Drug Design.

Carnevale V, Rohacs T.

Pharmaceuticals (Basel). 2016 Aug 23;9(3). pii: E52. doi: 10.3390/ph9030052. Review.

14.

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.

Velisetty P, Borbiro I, Kasimova MA, Liu L, Badheka D, Carnevale V, Rohacs T.

Sci Rep. 2016 Jun 13;6:27652. doi: 10.1038/srep27652.

15.

Phospholipase C δ4 regulates cold sensitivity in mice.

Yudin Y, Lutz B, Tao YX, Rohacs T.

J Physiol. 2016 Jul 1;594(13):3609-28. doi: 10.1113/JP272321. Epub 2016 May 29.

16.

Phosphoinositide signaling in somatosensory neurons.

Rohacs T.

Adv Biol Regul. 2016 May;61:2-16. doi: 10.1016/j.jbior.2015.11.012. Epub 2015 Dec 19. Review.

17.

Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin.

Elokely K, Velisetty P, Delemotte L, Palovcak E, Klein ML, Rohacs T, Carnevale V.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E137-45. doi: 10.1073/pnas.1517288113. Epub 2015 Dec 30.

18.

TRPM3 joins the ranks of PI(4,5)P2 sensitive ion channels.

Badheka D, Rohacs T.

Channels (Austin). 2015;9(5):233-4. doi: 10.1080/19336950.2015.1089072. No abstract available.

19.

Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel.

Badheka D, Borbiro I, Rohacs T.

J Gen Physiol. 2015 Jul;146(1):65-77. doi: 10.1085/jgp.201411336.

20.

Phosphoinositide regulation of TRPV1 revisited.

Rohacs T.

Pflugers Arch. 2015 Sep;467(9):1851-69. doi: 10.1007/s00424-015-1695-3. Epub 2015 Mar 11. Review.

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