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Items: 1 to 20 of 38


LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.

Pang JB, Molania R, Chand A, Knower K, Takano EA, Byrne DJ, Mikeska T, Millar EKA, Lee CS, O'Toole SA, Clyne C, Gorringe KL, Dobrovic A, Fox SB.

Oncotarget. 2017 Jul 28;8(48):83626-83636. doi: 10.18632/oncotarget.18886. eCollection 2017 Oct 13.


Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer.

Garsed DW, Alsop K, Fereday S, Emmanuel C, Kennedy CJ, Etemadmoghadam D, Gao B, Gebski V, Garès V, Christie EL, Wouters MCA, Milne K, George J, Patch AM, Li J, Arnau GM, Semple T, Gadipally SR, Chiew YE, Hendley J, Mikeska T, Zapparoli GV, Amarasinghe K, Grimmond SM, Pearson JV, Waddell N, Hung J, Stewart CJR, Sharma R, Allan PE, Rambau PF, McNally O, Mileshkin L, Hamilton A, Ananda S, Grossi M, Cohen PA, Leung YC, Rome RM, Beale P, Blomfield P, Friedlander M, Brand A, Dobrovic A, Köbel M, Harnett P, Nelson BH, Bowtell DDL, deFazio A; Nadia Traficante, for the Australian Ovarian Cancer Study Group.

Clin Cancer Res. 2018 Feb 1;24(3):569-580. doi: 10.1158/1078-0432.CCR-17-1621. Epub 2017 Oct 23.


Assessing alternative base substitutions at primer CpG sites to optimise unbiased PCR amplification of methylated sequences.

Candiloro ILM, Mikeska T, Dobrovic A.

Clin Epigenetics. 2017 Apr 4;9:31. doi: 10.1186/s13148-017-0328-4. eCollection 2017.


Fc-γ Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer.

Liu G, Tu D, Lewis M, Cheng D, Sullivan LA, Chen Z, Morgen E, Simes J, Price TJ, Tebbutt NC, Shapiro JD, Jeffery GM, Mellor JD, Mikeska T, Virk S, Shepherd LE, Jonker DJ, O'Callaghan CJ, Zalcberg JR, Karapetis CS, Dobrovic A.

Clin Cancer Res. 2016 May 15;22(10):2435-44. doi: 10.1158/1078-0432.CCR-15-0414.


MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing.

Wong NC, Pope BJ, Candiloro IL, Korbie D, Trau M, Wong SQ, Mikeska T, Zhang X, Pitman M, Eggers S, Doyle SR, Dobrovic A.

BMC Bioinformatics. 2016 Feb 24;17:98. doi: 10.1186/s12859-016-0950-8.


Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat.

Wong NC, Pope BJ, Candiloro I, Korbie D, Trau M, Wong SQ, Mikeska T, van Denderen BJ, Thompson EW, Eggers S, Doyle SR, Dobrovic A.

Gigascience. 2015 Nov 26;4:55. doi: 10.1186/s13742-015-0098-x. eCollection 2015.


Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour.

Huang KT, Mikeska T, Li J, Takano EA, Millar EK, Graham PH, Boyle SE, Campbell IG, Speed TP, Dobrovic A, Fox SB.

BMC Cancer. 2015 Oct 9;15:669. doi: 10.1186/s12885-015-1676-0.


DNA methylation biomarkers: cancer and beyond.

Mikeska T, Craig JM.

Genes (Basel). 2014 Sep 16;5(3):821-64. doi: 10.3390/genes5030821. Review.


Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations.

George J, Alsop K, Etemadmoghadam D, Hondow H, Mikeska T, Dobrovic A, deFazio A; Australian Ovarian Cancer Study Group, Smyth GK, Levine DA, Mitchell G, Bowtell DD.

Clin Cancer Res. 2013 Jul 1;19(13):3474-84. doi: 10.1158/1078-0432.CCR-13-0066. Epub 2013 Apr 30.


No evidence for PALB2 methylation in high-grade serous ovarian cancer.

Mikeska T, Alsop K; Australian Ovarian Cancer Study Group, Mitchell G, Bowtell DD, Dobrovic A.

J Ovarian Res. 2013 Apr 12;6(1):26. doi: 10.1186/1757-2215-6-26.


Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape.

Bidwell BN, Slaney CY, Withana NP, Forster S, Cao Y, Loi S, Andrews D, Mikeska T, Mangan NE, Samarajiwa SA, de Weerd NA, Gould J, Argani P, Möller A, Smyth MJ, Anderson RL, Hertzog PJ, Parker BS.

Nat Med. 2012 Aug;18(8):1224-31. doi: 10.1038/nm.2830. Epub 2012 Jul 22.


RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomas.

von dem Knesebeck A, Felsberg J, Waha A, Hartmann W, Scheffler B, Glas M, Hammes J, Mikeska T, Yan PS, Endl E, Simon M, Reifenberger G, Pietsch T, Waha A.

Neoplasia. 2012 Jun;14(6):526-34.


DNA methylation biomarkers in cancer: progress towards clinical implementation.

Mikeska T, Bock C, Do H, Dobrovic A.

Expert Rev Mol Diagn. 2012 Jun;12(5):473-87. doi: 10.1586/erm.12.45. Review.


No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia.

Mikeska T, Carney DA, Seymour JF, Dobrovic A.

Leuk Lymphoma. 2012 Jul;53(7):1420-2. doi: 10.3109/10428194.2011.653640. Epub 2012 Jan 31. No abstract available.


Closed-tube PCR methods for locus-specific DNA methylation analysis.

Candiloro IL, Mikeska T, Dobrovic A.

Methods Mol Biol. 2011;791:55-71. doi: 10.1007/978-1-61779-316-5_5.


Analysing DNA methylation using bisulphite pyrosequencing.

Mikeska T, Felsberg J, Hewitt CA, Dobrovic A.

Methods Mol Biol. 2011;791:33-53. doi: 10.1007/978-1-61779-316-5_4.


Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.

Huang KT, Takano EA, Mikeska T, Byrne DJ, Dobrovic A, Fox SB.

Breast Cancer Res Treat. 2011 Nov;130(1):319-29. doi: 10.1007/s10549-011-1657-1. Epub 2011 Jul 14.


A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues.

Takano EA, Mikeska T, Dobrovic A, Byrne DJ, Fox SB.

BMC Biotechnol. 2010 Dec 17;10:89. doi: 10.1186/1472-6750-10-89.


DNA methylation analysis of the HIF-1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas.

Huang KT, Mikeska T, Dobrovic A, Fox SB.

Histopathology. 2010 Sep;57(3):451-60. doi: 10.1111/j.1365-2559.2010.03633.x. Epub 2010 Aug 19.


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