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Items: 1 to 20 of 56

1.

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.

Hanke T, Wong JF, Berger BT, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, Müller S, Knapp S.

ACS Chem Biol. 2020 Mar 20. doi: 10.1021/acschembio.0c00076. [Epub ahead of print]

PMID:
32176847
2.

Crayfish hemocyanin on chitin bone substitute scaffolds promotes the proliferation and osteogenic differentiation of human mesenchymal stem cells.

Kruppke B, Farack J, Weil S, Aflalo ED, Poláková D, Sagi A, Hanke T.

J Biomed Mater Res A. 2020 Mar;108(3):694-708. doi: 10.1002/jbm.a.36849. Epub 2019 Dec 8.

PMID:
31755232
3.

Biomaterial based treatment of osteoclastic/osteoblastic cell imbalance - Gelatin-modified calcium/strontium phosphates.

Kruppke B, Wagner AS, Rohnke M, Heinemann C, Kreschel C, Gebert A, Wiesmann HP, Mazurek S, Wenisch S, Hanke T.

Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109933. doi: 10.1016/j.msec.2019.109933. Epub 2019 Jul 3.

PMID:
31499966
4.

Organically modified hydroxyapatite (ormoHAP) nanospheres stimulate the differentiation of osteoblast and osteoclast precursors: a co-culture study.

Heinemann C, Heinemann S, Rößler S, Kruppke B, Wiesmann HP, Hanke T.

Biomed Mater. 2019 Apr 15;14(3):035015. doi: 10.1088/1748-605X/ab0fad.

PMID:
30870824
5.

Strontium ions promote in vitro human bone marrow stromal cell proliferation and differentiation in calcium-lacking media.

Kruppke B, Heinemann C, Wagner AS, Farack J, Wenisch S, Wiesmann HP, Hanke T.

Dev Growth Differ. 2019 Feb;61(2):166-175. doi: 10.1111/dgd.12588. Epub 2018 Dec 25.

PMID:
30585307
6.

Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.

Cheung SY, Werner M, Esposito L, Troisi F, Cantone V, Liening S, König S, Gerstmeier J, Koeberle A, Bilancia R, Rizza R, Rossi A, Roviezzo F, Temml V, Schuster D, Stuppner H, Schubert-Zsilavecz M, Werz O, Hanke T, Pace S.

Eur J Med Chem. 2018 Aug 5;156:815-830. doi: 10.1016/j.ejmech.2018.07.031. Epub 2018 Jul 25.

PMID:
30053720
7.

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.

8.

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.

Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Hartnett JR, Ingold MR, Zimmerman K, Machleidt T, Kirkland TA, Huwiler KG, Ohana RF, Slater M, Otto P, Cong M, Wells CI, Berger BT, Hanke T, Glas C, Ding K, Drewry DH, Huber KVM, Willson TM, Knapp S, Müller S, Meisenheimer PL, Fan F, Wood KV, Robers MB.

Cell Chem Biol. 2018 Feb 15;25(2):206-214.e11. doi: 10.1016/j.chembiol.2017.10.010. Epub 2017 Nov 22.

9.

Drug Release as a function of bioactivity, incubation regime, liquid, and initial load: Release of bortezomib from calcium phosphate-containing silica/collagen xerogels.

Kruppke B, Hose D, Schnettler R, Seckinger A, Rößler S, Hanke T, Heinemann S.

J Biomed Mater Res B Appl Biomater. 2018 Apr;106(3):1165-1173. doi: 10.1002/jbm.b.33931. Epub 2017 May 29.

PMID:
28556562
10.

Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.

Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A.

Sci Signal. 2017 May 2;10(477). pii: eaai8133. doi: 10.1126/scisignal.aai8133.

11.

Cell behavior of human mesenchymal stromal cells in response to silica/collagen based xerogels and calcium deficient culture conditions.

Wagner AS, Glenske K, Henß A, Kruppke B, Rößler S, Hanke T, Moritz A, Rohnke M, Kressin M, Arnhold S, Schnettler R, Wenisch S.

Biomed Mater. 2017 Jul 4;12(4):045003. doi: 10.1088/1748-605X/aa6e29.

PMID:
28425919
12.

Osteogenic differentiation capacity of human mesenchymal stromal cells in response to extracellular calcium with special regard to connexin 43.

Wagner AS, Glenske K, Wolf V, Fietz D, Mazurek S, Hanke T, Moritz A, Arnhold S, Wenisch S.

Ann Anat. 2017 Jan;209:18-24. doi: 10.1016/j.aanat.2016.09.005. Epub 2016 Oct 13.

PMID:
27746221
13.

Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats.

Ray S, Thormann U, Sommer U, Khassawna TE, Hundgeburth M, Henß A, Rohnke M, Lips KS, Heiss C, Heinemann S, Hanke T, Dürselen L, Schnettler R, Alt V.

Injury. 2016 Jan;47 Suppl 1:S52-61. doi: 10.1016/S0020-1383(16)30013-4.

PMID:
26768293
14.

Gelatine modified monetite as a bone substitute material: An in vitro assessment of bone biocompatibility.

Kruppke B, Farack J, Wagner AS, Beckmann S, Heinemann C, Glenske K, Rößler S, Wiesmann HP, Wenisch S, Hanke T.

Acta Biomater. 2016 Mar 1;32:275-285. doi: 10.1016/j.actbio.2015.12.035. Epub 2015 Dec 28.

PMID:
26732518
15.

Small molecules with anti-inflammatory properties in clinical development.

Hanke T, Merk D, Steinhilber D, Geisslinger G, Schubert-Zsilavecz M.

Pharmacol Ther. 2016 Jan;157:163-87. doi: 10.1016/j.pharmthera.2015.11.011. Epub 2015 Nov 26. Review.

PMID:
26627986
16.

Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition.

Hanke T, Lamers C, Gomez RC, Schneider G, Werz O, Schubert-Zsilavecz M.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3757-63. doi: 10.1016/j.bmcl.2014.06.077. Epub 2014 Jul 3.

PMID:
25037914
17.

Live cell imaging of the intracellular compartmentalization of the contaminate benzo[a]pyrene.

Ali R, Trump S, Lehmann I, Hanke T.

J Biophotonics. 2015 May;8(5):361-71. doi: 10.1002/jbio.201300170. Epub 2014 Apr 3.

PMID:
24700684
18.

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR).

Merk D, Gabler M, Gomez RC, Flesch D, Hanke T, Kaiser A, Lamers C, Werz O, Schneider G, Schubert-Zsilavecz M.

Bioorg Med Chem. 2014 Apr 15;22(8):2447-60. doi: 10.1016/j.bmc.2014.02.053. Epub 2014 Mar 15.

PMID:
24685112
19.

Bioactivity of xerogels as modulators of osteoclastogenesis mediated by connexin 43.

Glenske K, Wagner AS, Hanke T, Cavalcanti-Adam EA, Heinemann S, Heinemann C, Kruppke B, Arnhold S, Moritz A, Schwab EH, Worch H, Wenisch S.

Biomaterials. 2014 Feb;35(5):1487-95. doi: 10.1016/j.biomaterials.2013.11.002. Epub 2013 Nov 20.

PMID:
24268200
20.

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

Hanke T, Rörsch F, Thieme TM, Ferreiros N, Schneider G, Geisslinger G, Proschak E, Grösch S, Schubert-Zsilavecz M.

Bioorg Med Chem. 2013 Dec 15;21(24):7874-83. doi: 10.1016/j.bmc.2013.10.006. Epub 2013 Oct 16.

PMID:
24183739

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