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Items: 1 to 20 of 34


The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver.

Mescher M, Tigges J, Rolfes KM, Shen AL, Yee JS, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T.

Arch Toxicol. 2019 May 20. doi: 10.1007/s00204-019-02488-5. [Epub ahead of print]


Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages.

Ishihara Y, Haarmann-Stemmann T, Kado NY, Vogel CFA.

Toxicol Sci. 2019 May 15. pii: kfz114. doi: 10.1093/toxsci/kfz114. [Epub ahead of print]


A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth.

Vogel CFA, Ishihara Y, Campbell CE, Kado SY, Nguyen-Chi A, Sweeney C, Pollet M, Haarmann-Stemmann T, Tuscano JM.

Cancers (Basel). 2019 Apr 27;11(5). pii: E589. doi: 10.3390/cancers11050589.


Commentary: Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!

Pollet M, Krutmann J, Haarmann-Stemmann T.

Front Pharmacol. 2018 Aug 20;9:935. doi: 10.3389/fphar.2018.00935. eCollection 2018. No abstract available.


The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis.

Pollet M, Shaik S, Mescher M, Frauenstein K, Tigges J, Braun SA, Sondenheimer K, Kaveh M, Bruhs A, Meller S, Homey B, Schwarz A, Esser C, Douki T, Vogel CFA, Krutmann J, Haarmann-Stemmann T.

Cell Death Differ. 2018 Nov;25(10):1823-1836. doi: 10.1038/s41418-018-0160-1. Epub 2018 Jul 16.


Alternative test models for skin ageing research.

Nakamura M, Haarmann-Stemmann T, Krutmann J, Morita A.

Exp Dermatol. 2018 May;27(5):495-500. doi: 10.1111/exd.13519. Epub 2018 Apr 10.


Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options.

Mescher M, Haarmann-Stemmann T.

Pharmacol Ther. 2018 Jul;187:71-87. doi: 10.1016/j.pharmthera.2018.02.012. Epub 2018 Feb 17. Review.


The aryl hydrocarbon receptor repressor - More than a simple feedback inhibitor of AhR signaling: Clues for its role in inflammation and cancer.

Vogel CFA, Haarmann-Stemmann T.

Curr Opin Toxicol. 2017 Feb;2:109-119. doi: 10.1016/j.cotox.2017.02.004. Epub 2017 Mar 1.


Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.

Brandstätter O, Schanz O, Vorac J, König J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H, Förster I.

Sci Rep. 2016 May 17;6:26091. doi: 10.1038/srep26091.


Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity.

Vogel CF, Chang WL, Kado S, McCulloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F, Gershwin ME.

Environ Health Perspect. 2016 Jul;124(7):1071-83. doi: 10.1289/ehp.1510194. Epub 2016 Feb 5.


The aryl hydrocarbon receptor promotes aging phenotypes across species.

Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N, Haendeler J.

Sci Rep. 2016 Jan 21;6:19618. doi: 10.1038/srep19618.


The Janus-Faced Role of Aryl Hydrocarbon Receptor Signaling in the Skin: Consequences for Prevention and Treatment of Skin Disorders.

Haarmann-Stemmann T, Esser C, Krutmann J.

J Invest Dermatol. 2015 Nov;135(11):2572-2576. doi: 10.1038/jid.2015.285. Epub 2015 Aug 13. Review.


COX inhibition enhances inflammatory immune cell infiltration in UV-irradiated human skin: implications for the treatment of sunburn.

Nakamura M, Haarmann-Stemmann T, Krutmann J.

Exp Dermatol. 2015 Oct;24(10):734-5. doi: 10.1111/exd.12783. Epub 2015 Aug 21. No abstract available.


The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells.

Bekki K, Vogel H, Li W, Ito T, Sweeney C, Haarmann-Stemmann T, Matsumura F, Vogel CF.

Pestic Biochem Physiol. 2015 May;120:5-13. doi: 10.1016/j.pestbp.2014.12.021. Epub 2014 Dec 23.


Environment-induced lentigines: formation of solar lentigines beyond ultraviolet radiation.

Nakamura M, Morita A, Seité S, Haarmann-Stemmann T, Grether-Beck S, Krutmann J.

Exp Dermatol. 2015 Jun;24(6):407-11. doi: 10.1111/exd.12690. Epub 2015 Apr 16.


Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells.

Bruhs A, Haarmann-Stemmann T, Frauenstein K, Krutmann J, Schwarz T, Schwarz A.

J Invest Dermatol. 2015 Feb;135(2):435-444. doi: 10.1038/jid.2014.419. Epub 2014 Sep 24.


Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2).

Frauenstein K, Tigges J, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CF, Haarmann-Stemmann T.

Arch Toxicol. 2015 Aug;89(8):1329-36. doi: 10.1007/s00204-014-1321-8. Epub 2014 Aug 1.


Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB.

Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WL, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS.

J Biol Chem. 2014 Jan 17;289(3):1866-75. doi: 10.1074/jbc.M113.505578. Epub 2013 Dec 3.


The interleukin-6-type cytokine oncostatin M induces aryl hydrocarbon receptor expression in a STAT3-dependent manner in human HepG2 hepatoma cells.

Stobbe-Maicherski N, Wolff S, Wolff C, Abel J, Sydlik U, Frauenstein K, Haarmann-Stemmann T.

FEBS J. 2013 Dec;280(24):6681-90. doi: 10.1111/febs.12571. Epub 2013 Nov 11.


Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells.

Vrzal R, Frauenstein K, Proksch P, Abel J, Dvorak Z, Haarmann-Stemmann T.

PLoS One. 2013 Sep 19;8(9):e74917. doi: 10.1371/journal.pone.0074917. eCollection 2013.

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