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The antiarrhythmic compound efsevin directly modulates voltage-dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca2+ uptake.

Wilting F, Kopp R, Gurnev PA, Schedel A, Dupper NJ, Kwon O, Nicke A, Gudermann T, Schredelseker J.

Br J Pharmacol. 2020 Feb 14. doi: 10.1111/bph.15022. [Epub ahead of print]


Expression of Taste Receptor 2 Subtypes in Human Testis and Sperm.

Governini L, Semplici B, Pavone V, Crifasi L, Marrocco C, De Leo V, Arlt E, Gudermann T, Boekhoff I, Luddi A, Piomboni P.

J Clin Med. 2020 Jan 18;9(1). pii: E264. doi: 10.3390/jcm9010264.


Helix 8 is the essential structural motif of mechanosensitive GPCRs.

Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos Y Schnitzler M.

Nat Commun. 2019 Dec 19;10(1):5784. doi: 10.1038/s41467-019-13722-0.


Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity.

Voringer S, Schreyer L, Nadolni W, Meier MA, Woerther K, Mittermeier C, Ferioli S, Singer S, Holzer K, Zierler S, Chubanov V, Liebl B, Gudermann T, Muehlich S.

Oncogene. 2019 Dec 16. doi: 10.1038/s41388-019-1140-8. [Epub ahead of print]


Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity.

Gohlsch K, Mückter H, Steinritz D, Aufderheide M, Hoffmann S, Gudermann T, Breit A.

Toxicol Lett. 2019 Nov;316:119-126. doi: 10.1016/j.toxlet.2019.09.014. Epub 2019 Sep 17.


Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro.

Lüling R, Singer H, Popp T, John H, Boekhoff I, Thiermann H, Daumann LJ, Karaghiosoff K, Gudermann T, Steinritz D.

Arch Toxicol. 2019 Nov;93(11):3141-3152. doi: 10.1007/s00204-019-02571-x. Epub 2019 Sep 12.


Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.

Steinritz D, Lang S, Popp T, Siegert M, Rothmiller S, Kranawetvogl A, Schmidt A, John H, Gudermann T, Thiermann H, Kehe K.

Toxicol Lett. 2019 Oct 10;314:172-180. doi: 10.1016/j.toxlet.2019.07.023. Epub 2019 Aug 9.


Small Fluorescein Arsenical Hairpin-Based Förster Resonance Energy Transfer Analysis Reveals Changes in Amino- to Carboxyl-Terminal Interactions upon OAG Activation of Classical Transient Receptor Potential 6.

Fiedler S, Storch U, Erdogmus S, Gudermann T, Mederos Y Schnitzler M, Dietrich A.

Mol Pharmacol. 2019 Jul;96(1):90-98. doi: 10.1124/mol.119.115949.


Validation of the CULTEX® Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles.

Tsoutsoulopoulos A, Gohlsch K, Möhle N, Breit A, Hoffmann S, Krischenowski O, Mückter H, Gudermann T, Thiermann H, Aufderheide M, Steinritz D.

Toxicol In Vitro. 2019 Aug;58:245-255. doi: 10.1016/j.tiv.2019.03.020. Epub 2019 Mar 16.


Taste Receptors: New Players in Sperm Biology.

Luddi A, Governini L, Wilmskötter D, Gudermann T, Boekhoff I, Piomboni P.

Int J Mol Sci. 2019 Feb 22;20(4). pii: E967. doi: 10.3390/ijms20040967. Review.


TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival.

Mittermeier L, Demirkhanyan L, Stadlbauer B, Breit A, Recordati C, Hilgendorff A, Matsushita M, Braun A, Simmons DG, Zakharian E, Gudermann T, Chubanov V.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4706-4715. doi: 10.1073/pnas.1810633116. Epub 2019 Feb 15.


A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure.

Tsoutsoulopoulos A, Siegert M, John H, Zubel T, Mangerich A, Schmidt A, Mückter H, Gudermann T, Thiermann H, Steinritz D, Popp T.

Chem Biol Interact. 2019 Jan 25;298:121-128. doi: 10.1016/j.cbi.2018.11.025. Epub 2018 Nov 28.


TRPM7 reflected in Cryo-EMirror.

Chubanov V, Mittermeier L, Gudermann T.

Cell Calcium. 2018 Dec;76:129-131. doi: 10.1016/j.ceca.2018.11.004. Epub 2018 Nov 15.


Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels.

Mederos Y Schnitzler M, Gudermann T, Storch U.

Cells. 2018 Nov 20;7(11). pii: E218. doi: 10.3390/cells7110218. Review.


Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication.

Menacher G, Balszuweit F, Lang S, Thiermann H, Kehe K, Gudermann T, Schmidt A, Steinritz D, Popp T.

Chem Biol Interact. 2019 Jan 25;298:80-85. doi: 10.1016/j.cbi.2018.10.030. Epub 2018 Nov 2.


Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling.

Breit A, Miek L, Schredelseker J, Geibel M, Merrow M, Gudermann T.

J Biol Chem. 2018 Nov 2;293(44):17278-17290. doi: 10.1074/jbc.RA118.004429. Epub 2018 Sep 14.


Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro.

Lüling R, John H, Gudermann T, Thiermann H, Mückter H, Popp T, Steinritz D.

Cells. 2018 Aug 31;7(9). pii: E126. doi: 10.3390/cells7090126.


Sarcopenia - Endocrinological and Neurological Aspects.

Stangl MK, Böcker W, Chubanov V, Ferrari U, Fischereder M, Gudermann T, Hesse E, Meinke P, Reincke M, Reisch N, Saller MM, Seissler J, Schmidmaier R, Schoser B, Then C, Thorand B, Drey M.

Exp Clin Endocrinol Diabetes. 2019 Jan;127(1):8-22. doi: 10.1055/a-0672-1007. Epub 2018 Sep 10. Review.


TRPs in Tox: Involvement of Transient Receptor Potential-Channels in Chemical-Induced Organ Toxicity-A Structured Review.

Steinritz D, Stenger B, Dietrich A, Gudermann T, Popp T.

Cells. 2018 Aug 7;7(8). pii: E98. doi: 10.3390/cells7080098. Review.


An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

Khajavi N, Finan B, Kluth O, Müller TD, Mergler S, Schulz A, Kleinau G, Scheerer P, Schürmann A, Gudermann T, Tschöp MH, Krude H, DiMarchi RD, Biebermann H.

Cell Signal. 2018 Nov;51:13-22. doi: 10.1016/j.cellsig.2018.07.006. Epub 2018 Jul 25.


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