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Items: 1 to 20 of 71


A Comparison of the Ability of Leu8- and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin Receptors.

Pierce ML, Mehrotra S, Mustoe AC, French JA, Murray TF.

Mol Pharmacol. 2019 Apr;95(4):376-385. doi: 10.1124/mol.118.114744. Epub 2019 Feb 9.


Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp.

Tao Y, Li P, Zhang D, Glukhov E, Gerwick L, Zhang C, Murray TF, Gerwick WH.

J Org Chem. 2018 Mar 16;83(6):3034-3046. doi: 10.1021/acs.joc.8b00028. Epub 2018 Mar 8.


Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl).

Fang WJ, Murray TF, Aldrich JV.

Bioorg Med Chem. 2018 Mar 15;26(6):1157-1161. doi: 10.1016/j.bmc.2017.11.029. Epub 2017 Nov 21.


Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species.

Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH.

J Nat Prod. 2017 Aug 25;80(8):2328-2334. doi: 10.1021/acs.jnatprod.7b00367. Epub 2017 Aug 7.


Alanine scan of the opioid peptide dynorphin B amide.

Joshi AA, Murray TF, Aldrich JV.

Biopolymers. 2017 Sep;108(5). doi: 10.1002/bip.23026.


A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens.

Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick WH.

J Nat Prod. 2017 May 26;80(5):1514-1521. doi: 10.1021/acs.jnatprod.7b00019. Epub 2017 Apr 27.


Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection.

Philkhana SC, Mehrotra S, Murray TF, Reddy DS.

Org Biomol Chem. 2016 Sep 28;14(36):8457-73. doi: 10.1039/c6ob01372d. Epub 2016 Aug 18.


Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin.

Joshi AA, Murray TF, Aldrich JV.

J Med Chem. 2015 Nov 25;58(22):8783-95. doi: 10.1021/jm501827k. Epub 2015 Nov 16.


Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows.

Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH.

PLoS One. 2015 Jul 29;10(7):e0133297. doi: 10.1371/journal.pone.0133297. eCollection 2015.


Involvement of JNK and caspase activation in hoiamide A-induced neurotoxicity in neocortical neurons.

Cao Z, Li X, Zou X, Greenwood M, Gerwick WH, Murray TF.

Mar Drugs. 2015 Feb 10;13(2):903-19. doi: 10.3390/md13020903.


Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists.

Mehrotra S, Duggan BM, Tello-Aburto R, Newar TD, Gerwick WH, Murray TF, Maio WA.

J Nat Prod. 2014 Nov 26;77(11):2553-60. doi: 10.1021/np500644k. Epub 2014 Oct 24.


Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons.

Cao Z, Cui Y, Busse E, Mehrotra S, Rainier JD, Murray TF.

J Pharmacol Exp Ther. 2014 Sep;350(3):615-23. doi: 10.1124/jpet.114.215319. Epub 2014 Jun 23.


Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics.

Lesma G, Salvadori S, Airaghi F, Murray TF, Recca T, Sacchetti A, Balboni G, Silvani A.

ACS Med Chem Lett. 2013 Jul 11;4(8):795-9. doi: 10.1021/ml400189r. eCollection 2013 Aug 8.


Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx.

Li H, Bowling JJ, Fronczek FR, Hong J, Jabba SV, Murray TF, Ha NC, Hamann MT, Jung JH.

Biochim Biophys Acta. 2013 Mar;1830(3):2591-9.


Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity.

George J, Baden DG, Gerwick WH, Murray TF.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19840-5. doi: 10.1073/pnas.1212584109. Epub 2012 Nov 12.


Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.

Reith ME, Ali S, Hashim A, Sheikh IS, Theddu N, Gaddiraju NV, Mehrotra S, Schmitt KC, Murray TF, Sershen H, Unterwald EM, Davis FA.

J Pharmacol Exp Ther. 2012 Nov;343(2):413-25. doi: 10.1124/jpet.112.193771. Epub 2012 Aug 15.


Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.

Nunnery JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick WH.

J Org Chem. 2012 May 4;77(9):4198-208. doi: 10.1021/jo300160e. Epub 2012 Apr 19.


Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.

Malloy KL, Suyama TL, Engene N, Debonsi H, Cao Z, Matainaho T, Spadafora C, Murray TF, Gerwick WH.

J Nat Prod. 2012 Jan 27;75(1):60-6. doi: 10.1021/np200611f. Epub 2011 Dec 12.


Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208.

Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP.

ChemMedChem. 2011 Sep 5;6(9):1739-45. doi: 10.1002/cmdc.201100113. Epub 2011 Jul 14.


Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera.

Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH.

J Nat Prod. 2011 Aug 26;74(8):1737-43. doi: 10.1021/np200236c. Epub 2011 Jul 13.

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