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Euphosantianane A⁻D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae.

Hegazy MF, Hamed AR, Ibrahim MAA, Talat Z, Reda EH, Abdel-Azim NS, Hammouda FM, Nakamura S, Matsuda H, Haggag EG, Paré PW, Efferth T.

Molecules. 2018 Sep 1;23(9). pii: E2221. doi: 10.3390/molecules23092221.


Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells.

Li T, Sun W, Dong X, Yu W, Cai J, Yuan Q, Shan L, Efferth T.

Oncol Lett. 2018 Oct;16(4):4640-4648. doi: 10.3892/ol.2018.9192. Epub 2018 Jul 23.


Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells.

Mbaveng AT, Fotso GW, Ngnintedo D, Kuete V, Ngadjui BT, Keumedjio F, Andrae-Marobela K, Efferth T.

Phytomedicine. 2018 Sep 15;48:112-119. doi: 10.1016/j.phymed.2017.12.016. Epub 2017 Dec 18.


Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts.

Efferth T, Banerjee M, Abu-Darwish MS, Abdelfatah S, Böckers M, Bhakta-Guha D, Bolzani V, Daak S, Demirezer ÖL, Dawood M, Efferth M, El-Seedi HR, Fischer N, Greten HJ, Hamdoun S, Hong C, Horneber M, Kadioglu O, Khalid HE, Khalid SA, Kuete V, Mahmoud N, Marin J, Mbaveng A, Midiwo J, Nakagawa H, Naß J, Ngassapa O, Ochwang'i D, Omosa LK, Ooko EA, Özenver N, Poornima P, Romero MR, Saeed MEM, Salgueiro L, Seo EJ, Yan G, Yasin Z, Saeed EM, Paul NW.

Phytomedicine. 2018 Jun 11. pii: S0944-7113(18)30190-9. doi: 10.1016/j.phymed.2018.06.007. [Epub ahead of print] Review.


Correction: Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1.

Yin SY, Efferth T, Jian FY, Chen YH, Liu CI, Wang AHJ, Chen YR, Hsiao PW, Yang NS.

Oncotarget. 2018 Aug 14;9(63):32271. doi: 10.18632/oncotarget.26007. eCollection 2018 Aug 14.


Differentially Tolerized Mouse Antigen Presenting Cells Share a Common miRNA Signature Including Enhanced mmu-miR-223-3p Expression Which Is Sufficient to Imprint a Protolerogenic State.

Bros M, Youns M, Kollek V, Buchmüller D, Bollmann F, Seo EJ, Schupp J, Montermann E, Usanova S, Kleinert H, Efferth T, Reske-Kunz AB.

Front Pharmacol. 2018 Aug 17;9:915. doi: 10.3389/fphar.2018.00915. eCollection 2018.


Prevention from radiation damage by natural products.

Fischer N, Seo EJ, Efferth T.

Phytomedicine. 2018 Aug 1;47:192-200. doi: 10.1016/j.phymed.2017.11.005. Epub 2017 Nov 13. Review.


The activity of Artemisia spp. and their constituents against Trypanosomiasis.

Naß J, Efferth T.

Phytomedicine. 2018 Aug 1;47:184-191. doi: 10.1016/j.phymed.2018.06.002. Epub 2018 Jun 9. Review.


Prospecting for cytotoxic and antiprotozoal 4-aryl-4H-chromenes and 10-aryldihydropyrano[2,3-f]chromenes.

Martin EF, Mbaveng AT, de Moraes MH, Kuete V, Biavatti MW, Steindel M, Efferth T, Sandjo LP.

Arch Pharm (Weinheim). 2018 Aug 23. doi: 10.1002/ardp.201800100. [Epub ahead of print]


Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells.

Hegazy MF, Hamed AR, El-Halawany AM, Hussien TA, Abdelfatah S, Ohta S, Paré PW, Abdel-Sattar E, Efferth T.

Fitoterapia. 2018 Aug 13;130:54-60. doi: 10.1016/j.fitote.2018.08.002. [Epub ahead of print]


Natural Products as a Source for New Leads in Cancer Research and Treatment.

Cabral C, Efferth T, Pires IM, Severino P, Lemos MFL.

Evid Based Complement Alternat Med. 2018 Jul 15;2018:8243680. doi: 10.1155/2018/8243680. eCollection 2018. No abstract available.


The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior.

Abd El-Ghffar EA, Al-Sayed E, Shehata SM, Eldahshan OA, Efferth T.

Food Funct. 2018 Aug 15;9(8):4457-4468. doi: 10.1039/c8fo00538a.


Identification of fatal outcome in a childhood nasopharyngeal carcinoma patient by protein expression profiling.

Saeed MEM, Mertens R, Handgretinger R, Efferth T.

Int J Oncol. 2018 Oct;53(4):1721-1731. doi: 10.3892/ijo.2018.4491. Epub 2018 Jul 19.


Selective inhibition of P-gp transporter by goniothalamin derivatives sensitizes resistant cancer cells to chemotherapy.

Sachs J, Kadioglu O, Weber A, Mundorf V, Betz J, Efferth T, Pietruszka J, Teusch N.

J Nat Med. 2018 Jul 31. doi: 10.1007/s11418-018-1230-x. [Epub ahead of print]


Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against Plasmodium falciparum, Human Cytomegalovirus, and Leukemia Cells.

Fröhlich T, Reiter C, Ibrahim MM, Beutel J, Hutterer C, Zeitträger I, Bahsi H, Leidenberger M, Friedrich O, Kappes B, Efferth T, Marschall M, Tsogoeva SB.

ACS Omega. 2017 Jun 30;2(6):2422-2431. doi: 10.1021/acsomega.7b00310. Epub 2017 Jun 1.


The hydrolysis of 6-phosphogluconolactone in the second step of pentose phosphate pathway occurs via a two-water mechanism.

Fatima T, Rani S, Fischer S, Efferth T, Kiani FA.

Biophys Chem. 2018 Sep;240:98-106. doi: 10.1016/j.bpc.2018.06.002. Epub 2018 Jun 12.


2'-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways in Vitro and Vivo.

Wang P, Gao C, Guo N, Zhang SD, Wang W, Yao LP, Zhang J, Efferth T, Fu YJ.

Front Pharmacol. 2018 Jun 27;9:679. doi: 10.3389/fphar.2018.00679. eCollection 2018.


Theabrownin triggers DNA damage to suppress human osteosarcoma U2OS cells by activating p53 signalling pathway.

Jin W, Zhou L, Yan B, Yan L, Liu F, Tong P, Yu W, Dong X, Xie L, Zhang J, Xu Y, Li C, Yuan Q, Shan L, Efferth T.

J Cell Mol Med. 2018 Sep;22(9):4423-4436. doi: 10.1111/jcmm.13742. Epub 2018 Jul 11.


Antimicrobial and Antioxidant Activities of Natural Compounds.

Angiolella L, Sacchetti G, Efferth T.

Evid Based Complement Alternat Med. 2018 Jun 6;2018:1945179. doi: 10.1155/2018/1945179. eCollection 2018. No abstract available.


Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.

Fröhlich T, Reiter C, Saeed MEM, Hutterer C, Hahn F, Leidenberger M, Friedrich O, Kappes B, Marschall M, Efferth T, Tsogoeva SB.

ACS Med Chem Lett. 2017 Dec 21;9(6):534-539. doi: 10.1021/acsmedchemlett.7b00412. eCollection 2018 Jun 14.


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