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Items: 1 to 20 of 52


Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity.

Blackburn PR, Sullivan AE, Gerassimou AG, Kleinendorst L, Bersten DC, Cooiman M, Harris KG, Wierenga KJ, Klee EW, van Gerpen JA, Ross OA, van Haelst MM, Whitelaw ML, Caulfield TR, Atwal PS.

J Clin Endocrinol Metab. 2020 Jan 1;105(1). pii: dgz192. doi: 10.1210/clinem/dgz192.


Molecular Dynamics Simulations Suggest a Non-Doublet Decoding Model of -1 Frameshifting by tRNASer3.

Caulfield T, Coban M, Tek A, Flores SC.

Biomolecules. 2019 Nov 18;9(11). pii: E745. doi: 10.3390/biom9110745.


Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer.

Madamsetty VS, Pal K, Keshavan S, Caulfield TR, Dutta SK, Wang E, Fadeel B, Mukhopadhyay D.

Nanoscale. 2019 Nov 21;11(45):22006-22018. doi: 10.1039/c9nr05478b.


Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma.

Madamsetty VS, Pal K, Dutta SK, Wang E, Thompson JR, Banerjee RK, Caulfield TR, Mody K, Yen Y, Mukhopadhyay D, Huang HS.

Bioconjug Chem. 2019 Oct 16;30(10):2703-2713. doi: 10.1021/acs.bioconjchem.9b00632. Epub 2019 Oct 4.


Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo.

Fifield AL, Hanavan PD, Faigel DO, Sergienko E, Bobkov A, Meurice N, Petit JL, Polito A, Caulfield TR, Castle EP, Copland JA, Mukhopadhyay D, Pal K, Dutta SK, Luo H, Ho TH, Lake DF.

Mol Cancer Ther. 2020 Jan;19(1):112-122. doi: 10.1158/1535-7163.MCT-19-0233. Epub 2019 Oct 1.


Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.

Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G.

Nat Rev Neurol. 2019 Sep;15(9):501-518. doi: 10.1038/s41582-019-0228-7. Epub 2019 Jul 31. Review.


Genomic Observations of a Rare/Pathogenic SMAD3 Variant in Loeys⁻Dietz Syndrome 3 Confirmed by Protein Informatics and Structural Investigations.

Richter JE Jr, Samreen A, Vadlamudi C, Helmi H, Mohammad AN, Wierenga K, Hines S, Atwal PS, Caulfield TR.

Medicina (Kaunas). 2019 May 15;55(5). pii: E137. doi: 10.3390/medicina55050137.


Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.

Cohen I, Coban M, Shahar A, Sankaran B, Hockla A, Lacham S, Caulfield TR, Radisky ES, Papo N.

J Biol Chem. 2019 Mar 29;294(13):5105-5120. doi: 10.1074/jbc.RA118.007292. Epub 2019 Jan 30.


Protein informatics combined with multiple data sources enriches the clinical characterization of novel TRPV4 variant causing an intermediate skeletal dysplasia.

Hines SL, Richter JE Jr, Mohammad AN, Mahim J, Atwal PS, Caulfield TR.

Mol Genet Genomic Med. 2019 Mar;7(3):e566. doi: 10.1002/mgg3.566. Epub 2019 Jan 28.


Integrative data fusion for comprehensive assessment of a novel CHEK2 variant using combined genomics, imaging, and functional-structural assessments via protein informatics.

Hines SL, Mohammad AN, Jackson J, Macklin S, Caulfield TR.

Mol Omics. 2019 Feb 11;15(1):59-66. doi: 10.1039/c8mo00137e.


TRIO gene segregation in a family with cerebellar ataxia.

Hanna Al Shaikh R, Caulfield T, Strongosky AJ, Matthew M, Jansen-West KR, Prudencio M, Fryer JD, Petrucelli L, Uitti RJ, Wszolek ZK.

Neurol Neurochir Pol. 2018 Nov - Dec;52(6):743-749. doi: 10.1016/j.pjnns.2018.09.006. Epub 2018 Sep 22.


Protein modeling and clinical description of a novel in-frame GLB1 deletion causing GM1 gangliosidosis type II.

Richter JE Jr, Zimmermann MT, Blackburn PR, Mohammad AN, Klee EW, Pollard LM, Macmurdo CF, Atwal PS, Caulfield TR.

Mol Genet Genomic Med. 2018 Nov;6(6):1229-1235. doi: 10.1002/mgg3.454. Epub 2018 Sep 5.


Personalized molecular modeling for pinpointing associations of protein dysfunction and variants associated with hereditary cancer syndromes.

Macklin S, Mohammed A, Jackson J, Hines SL, Atwal PS, Caulfield T.

Mol Genet Genomic Med. 2018 Sep;6(5):805-810. doi: 10.1002/mgg3.447. Epub 2018 Jul 24.


Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.

Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L.

Cell Rep. 2018 Jul 17;24(3):529-537.e4. doi: 10.1016/j.celrep.2018.06.070.


Protein molecular modeling techniques investigating novel TAB2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational family.

Caulfield TR, Richter JE Jr, Brown EE, Mohammad AN, Judge DP, Atwal PS.

Mol Genet Genomic Med. 2018 Apr 26. doi: 10.1002/mgg3.401. [Epub ahead of print]


Whole Exome Sequencing and Molecular Modeling of a Missense Variant in TNFAIP3 That Segregates with Disease in a Family with Chronic Urticaria and Angioedema.

Harris AL, Blackburn PR, Richter JE Jr, Gass JM, Caulfield TR, Mohammad AN, Atwal PS.

Case Rep Genet. 2018 Feb 22;2018:6968395. doi: 10.1155/2018/6968395. eCollection 2018.


Protein molecular modeling shows residue T599 is critical to wild-type function of POLG and description of a novel variant associated with the SANDO phenotype.

Richter JE, Robles HG, Mauricio E, Mohammad A, Atwal PS, Caulfield TR.

Hum Genome Var. 2018 Apr 5;5:18016. doi: 10.1038/hgv.2018.16. eCollection 2018.


Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy.

von Roemeling CA, Caulfield TR, Marlow L, Bok I, Wen J, Miller JL, Hughes R, Hazlehurst L, Pinkerton AB, Radisky DC, Tun HW, Kim YSB, Lane AL, Copland JA.

Oncotarget. 2017 Oct 6;9(1):3-20. doi: 10.18632/oncotarget.21545. eCollection 2018 Jan 2.


A novel splice site variant in CYP11A1 in trans with the p.E314K variant in a male patient with congenital adrenal insufficiency.

Lara-Velazquez M, Perdomo-Pantoja A, Blackburn PR, Gass JM, Caulfield TR, Atwal PS.

Mol Genet Genomic Med. 2017 Nov;5(6):781-787. doi: 10.1002/mgg3.322. Epub 2017 Jul 20.


Multifaceted peptide assisted one-pot synthesis of gold nanoparticles for plectin-1 targeted gemcitabine delivery in pancreatic cancer.

Pal K, Al-Suraih F, Gonzalez-Rodriguez R, Dutta SK, Wang E, Kwak HS, Caulfield TR, Coffer JL, Bhattacharya S.

Nanoscale. 2017 Oct 19;9(40):15622-15634. doi: 10.1039/c7nr03172f.

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