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Primary and Immortalized Human Respiratory Cells Display Different Patterns of Cytotoxicity and Cytokine Release upon Exposure to Deoxynivalenol, Nivalenol and Fusarenon-X.

Ferreira Lopes S, Vacher G, Ciarlo E, Savova-Bianchi D, Roger T, Niculita-Hirzel H.

Toxins (Basel). 2017 Oct 25;9(11). pii: E337. doi: 10.3390/toxins9110337.


Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.

Ciarlo E, Heinonen T, Théroude C, Herderschee J, Mombelli M, Lugrin J, Pfefferlé M, Tyrrell B, Lensch S, Acha-Orbea H, Le Roy D, Auwerx J, Roger T.

Front Immunol. 2017 Aug 28;8:1037. doi: 10.3389/fimmu.2017.01037. eCollection 2017.


The Anticancer Peptide TAT-RasGAP317-326 Exerts Broad Antimicrobial Activity.

Heulot M, Jacquier N, Aeby S, Le Roy D, Roger T, Trofimenko E, Barras D, Greub G, Widmann C.

Front Microbiol. 2017 Jun 7;8:994. doi: 10.3389/fmicb.2017.00994. eCollection 2017.


Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.

Ciarlo E, Heinonen T, Lugrin J, Acha-Orbea H, Le Roy D, Auwerx J, Roger T.

Sci Rep. 2017 Jun 20;7(1):3853. doi: 10.1038/s41598-017-04263-x.


Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype.

Rosciszewski G, Cadena V, Murta V, Lukin J, Villarreal A, Roger T, Ramos AJ.

Mol Neurobiol. 2017 May 25. doi: 10.1007/s12035-017-0618-z. [Epub ahead of print]


Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination.

Choteau L, Vancraeyneste H, Le Roy D, Dubuquoy L, Romani L, Jouault T, Poulain D, Sendid B, Calandra T, Roger T, Jawhara S.

Gut Pathog. 2017 Feb 15;9:9. doi: 10.1186/s13099-017-0158-0. eCollection 2017.


Development of induced glioblastoma by implantation of a human xenograft in Yucatan minipig as a large animal model.

Khoshnevis M, Carozzo C, Bonnefont-Rebeix C, Belluco S, Leveneur O, Chuzel T, Pillet-Michelland E, Dreyfus M, Roger T, Berger F, Ponce F.

J Neurosci Methods. 2017 Apr 15;282:61-68. doi: 10.1016/j.jneumeth.2017.03.007. Epub 2017 Mar 9.


Plasma Levels of Macrophage Migration Inhibitory Factor and d-Dopachrome Tautomerase Show a Highly Specific Profile in Early Life.

Roger T, Schlapbach LJ, Schneider A, Weier M, Wellmann S, Marquis P, Vermijlen D, Sweep FC, Leng L, Bucala R, Calandra T, Giannoni E.

Front Immunol. 2017 Jan 25;8:26. doi: 10.3389/fimmu.2017.00026. eCollection 2017.


[Macrophage migration inhibitory factor (MIF), a regulator of neonatal innate immune response].

Giannoni É, Schneider A, Calandra T, Roger T.

Med Sci (Paris). 2016 Dec;32(12):1062-1064. doi: 10.1051/medsci/20163212006. Epub 2017 Jan 3. French. No abstract available.


Frequent Occupational Exposure to Fusarium Mycotoxins of Workers in the Swiss Grain Industry.

Niculita-Hirzel H, Hantier G, Storti F, Plateel G, Roger T.

Toxins (Basel). 2016 Dec 12;8(12). pii: E370.


Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo.

Ciarlo E, Heinonen T, Herderschee J, Fenwick C, Mombelli M, Le Roy D, Roger T.

Sci Rep. 2016 Nov 29;6:37944. doi: 10.1038/srep37944.


Study of Early Elevated Gas6 Plasma Level as a Predictor of Mortality in a Prospective Cohort of Patients with Sepsis.

Stalder G, Que YA, Calzavarini S, Burnier L, Kosinski C, Ballabeni P, Roger T, Calandra T, Duchosal MA, Liaudet L, Eggimann P, Angelillo-Scherrer A.

PLoS One. 2016 Oct 27;11(10):e0163542. doi: 10.1371/journal.pone.0163542. eCollection 2016.


Innate immune defects in HIV permissive cell lines.

Rausell A, Muñoz M, Martinez R, Roger T, Telenti A, Ciuffi A.

Retrovirology. 2016 Jun 27;13(1):43. doi: 10.1186/s12977-016-0275-8.


Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis.

Savva A, Brouwer MC, Roger T, Valls Serón M, Le Roy D, Ferwerda B, van der Ende A, Bochud PY, van de Beek D, Calandra T.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3597-602. doi: 10.1073/pnas.1520727113. Epub 2016 Mar 14.


Mouse Model of Respiratory Tract Infection Induced by Waddlia chondrophila.

Pilloux L, LeRoy D, Brunel C, Roger T, Greub G.

PLoS One. 2016 Mar 7;11(3):e0150909. doi: 10.1371/journal.pone.0150909. eCollection 2016.


High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates.

Roger T, Schneider A, Weier M, Sweep FC, Le Roy D, Bernhagen J, Calandra T, Giannoni E.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E997-1005. doi: 10.1073/pnas.1514018113. Epub 2016 Feb 8.


Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model.

Kaderli S, Viguier E, Watrelot-Virieux D, Roger T, Gurny R, Scapozza L, Möller M, Boulocher C, Jordan O.

Eur J Pharm Biopharm. 2015 Oct;96:388-95. doi: 10.1016/j.ejpb.2015.09.005. Epub 2015 Sep 11.


T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M.

Nat Immunol. 2015 Sep;16(9):970-9. doi: 10.1038/ni.3211. Epub 2015 Jul 13.


Innate Immune Sensing of Fusarium culmorum by Mouse Dendritic Cells.

Vacher G, Ciarlo E, Savova-Bianchi D, Le Roy D, Hantier G, Niculita-Hirzel H, Roger T.

J Toxicol Environ Health A. 2015;78(13-14):871-85. doi: 10.1080/15287394.2015.1051201.


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