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Items: 1 to 20 of 32


Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.

Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA.

Cell Stem Cell. 2019 Jun 13. pii: S1934-5909(19)30217-6. doi: 10.1016/j.stem.2019.05.013. [Epub ahead of print]


Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.

Bal E, Park HS, Belaid-Choucair Z, Kayserili H, Naville M, Madrange M, Chiticariu E, Hadj-Rabia S, Cagnard N, Kuonen F, Bachmann D, Huber M, Le Gall C, Côté F, Hanein S, Rosti RÖ, Aslanger AD, Waisfisz Q, Bodemer C, Hermine O, Morice-Picard F, Labeille B, Caux F, Mazereeuw-Hautier J, Philip N, Levy N, Taieb A, Avril MF, Headon DJ, Gyapay G, Magnaldo T, Fraitag S, Crollius HR, Vabres P, Hohl D, Munnich A, Smahi A.

Nat Med. 2017 Oct;23(10):1226-1233. doi: 10.1038/nm.4368. Epub 2017 Sep 4.


Basal Cell Carcinoma in Gorlin's Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?

Gache Y, Brellier F, Rouanet S, Al-Qaraghuli S, Goncalves-Maia M, Burty-Valin E, Barnay S, Scarzello S, Ruat M, Sevenet N, Avril MF, Magnaldo T.

PLoS One. 2015 Dec 22;10(12):e0145369. doi: 10.1371/journal.pone.0145369. eCollection 2015.


Overexpression of galectin-7 in mouse epidermis leads to loss of cell junctions and defective skin repair.

Gendronneau G, Sanii S, Dang T, Deshayes F, Delacour D, Pichard E, Advedissian T, Sidhu SS, Viguier M, Magnaldo T, Poirier F.

PLoS One. 2015 Mar 5;10(3):e0119031. doi: 10.1371/journal.pone.0119031. eCollection 2015.


ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis.

Weber TJ, Magnaldo T, Xiong Y.

Proteomes. 2014 Sep 11;2(3):451-467. doi: 10.3390/proteomes2030451.


Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis.

Wright AT, Magnaldo T, Sontag RL, Anderson LN, Sadler NC, Piehowski PD, Gache Y, Weber TJ.

Mol Carcinog. 2015 Jun;54(6):473-84. doi: 10.1002/mc.22115. Epub 2013 Nov 27.


Genetic correction of stem cells in the treatment of inherited diseases and focus on xeroderma pigmentosum.

Rouanet S, Warrick E, Gache Y, Scarzello S, Avril MF, Bernerd F, Magnaldo T.

Int J Mol Sci. 2013 Oct 9;14(10):20019-36. doi: 10.3390/ijms141020019. Review.


Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells.

Warrick E, Garcia M, Chagnoleau C, Chevallier O, Bergoglio V, Sartori D, Mavilio F, Angulo JF, Avril MF, Sarasin A, Larcher F, Del Rio M, Bernerd F, Magnaldo T.

Mol Ther. 2012 Apr;20(4):798-807. doi: 10.1038/mt.2011.233. Epub 2011 Nov 8.


Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells.

Villeneuve C, Baricault L, Canelle L, Barboule N, Racca C, Monsarrat B, Magnaldo T, Larminat F.

Mol Biol Cell. 2011 Apr;22(7):999-1013. doi: 10.1091/mbc.E10-06-0534. Epub 2011 Feb 2.


[Dermal fibroblasts exert a key influence in the development of basal-cell skin cancers: the model of Gorlin syndrome].

Valin A, Avril MF, Magnaldo T.

Med Sci (Paris). 2010 Jan;26(1):22-5. doi: 10.1051/medsci/201026122. French. No abstract available.


Increased galectin-7 gene expression in lymphoma cells is under the control of DNA methylation.

Demers M, Couillard J, Giglia-Mari G, Magnaldo T, St-Pierre Y.

Biochem Biophys Res Commun. 2009 Sep 25;387(3):425-9. doi: 10.1016/j.bbrc.2009.07.015. Epub 2009 Jul 9.


PTCH1 +/- dermal fibroblasts isolated from healthy skin of Gorlin syndrome patients exhibit features of carcinoma associated fibroblasts.

Valin A, Barnay-Verdier S, Robert T, Ripoche H, Brellier F, Chevallier-Lagente O, Avril MF, Magnaldo T.

PLoS One. 2009;4(3):e4818. doi: 10.1371/journal.pone.0004818. Epub 2009 Mar 16.


Galectin-7 in the control of epidermal homeostasis after injury.

Gendronneau G, Sidhu SS, Delacour D, Dang T, Calonne C, Houzelstein D, Magnaldo T, Poirier F.

Mol Biol Cell. 2008 Dec;19(12):5541-9. doi: 10.1091/mbc.E08-02-0166. Epub 2008 Oct 1.


[Cutaneous gene therapy: the graft takes].

Bergoglio V, Warrick E, Chevallier-Lagente O, Magnaldo T.

Med Sci (Paris). 2008 Jun-Jul;24(6-7):607-14. doi: 10.1051/medsci/20082467607. Review. French.


[Epidermal stem cells and ex vivo cutaneous gene therapy: application to xeroderma pigmentosum].

Warrick E, Bergoglio V, Bernerd F, Magnaldo T.

J Soc Biol. 2008;202(1):33-41. doi: 10.1051/jbio:2008005. Epub 2008 May 8. French.


Safe selection of genetically manipulated human primary keratinocytes with very high growth potential using CD24.

Bergoglio V, Larcher F, Chevallier-Lagente O, Bernheim A, Danos O, Sarasin A, Rio MD, Magnaldo T.

Mol Ther. 2007 Dec;15(12):2186-93. Epub 2007 Aug 21.


Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.

Dennler S, André J, Alexaki I, Li A, Magnaldo T, ten Dijke P, Wang XJ, Verrecchia F, Mauviel A.

Cancer Res. 2007 Jul 15;67(14):6981-6.


[Suntanning and p53].

Magnaldo T.

Med Sci (Paris). 2007 Jun-Jul;23(6-7):581-3. French. No abstract available.


BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.

Gosselet FP, Magnaldo T, Culerrier RM, Sarasin A, Ehrhart JC.

Cell Signal. 2007 Apr;19(4):731-9. Epub 2006 Oct 4.


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