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Curr Opin Neurobiol. 2017 Aug;45:66-77. doi: 10.1016/j.conb.2017.04.003. Epub 2017 Apr 28.

Organizers of inhibitory synapses come of age.

Author information

1
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Straße 3, 37075 Göttingen, Germany. Electronic address: krueger@em.mpg.de.
2
Department of Molecular Biology, Center of Biochemistry and Molecular Cell Biology, Universitätsmedizin Göttingen, Humboldtallee 23, 37073 Göttingen, Germany. Electronic address: theofilos.papadopoulos@med.uni-goettingen.de.
3
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Straße 3, 37075 Göttingen, Germany.

Abstract

While the postsynaptic density of excitatory synapses is known to encompass a highly complex molecular machinery, the equivalent organizational structure of inhibitory synapses has long remained largely undefined. In recent years, however, substantial progress has been made towards identifying the full complement of organizational proteins present at inhibitory synapses, including submembranous scaffolds, intracellular signaling proteins, transsynaptic adhesion proteins, and secreted factors. Here, we summarize these findings and discuss future challenges in assigning synapse-specific functions to the newly discovered catalog of proteins, an endeavor that will depend heavily on newly developed technologies such as proximity biotinylation. Further advances are made all the more essential by growing evidence that links inhibitory synapses to psychiatric and neurological disorders.

PMID:
28460365
DOI:
10.1016/j.conb.2017.04.003
[Indexed for MEDLINE]

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