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Items: 1 to 20 of 73


Suppression of Human Platelet Activation via Integrin αIIbβ3 Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene.

Hsia CW, Tsai CL, Sheu JR, Lu WJ, Hsia CH, Velusamy M, Jayakumar T, Li JY.

Int J Mol Sci. 2019 Nov 8;20(22). pii: E5585. doi: 10.3390/ijms20225585.


A Critical Period for the Development of Schizophrenia-Like Pathology by Aberrant Postnatal Neurogenesis.

Sheu JR, Hsieh CY, Jayakumar T, Tseng MF, Lee HN, Huang SW, Manubolu M, Yang CH.

Front Neurosci. 2019 Jun 18;13:635. doi: 10.3389/fnins.2019.00635. eCollection 2019.


Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2-PKC-AKT Activation in Human Platelets.

Hsia CW, Lin KC, Lee TY, Hsia CH, Chou DS, Jayakumar T, Velusamy M, Chang CC, Sheu JR.

Int J Mol Sci. 2019 Jun 3;20(11). pii: E2731. doi: 10.3390/ijms20112731.


Ruthenium complex, TQ‑5, protects against LPS‑induced macrophage inflammation and acute liver injury in mice via downregulating NF‑κB pathways.

Hou SM, Hsia CH, Velusamy M, Jayakumar T, Hsia CW, Chang CC, Lin KH, Lu YC.

Int J Mol Med. 2019 Jul;44(1):335-345. doi: 10.3892/ijmm.2019.4179. Epub 2019 May 3.


[Corrigendum] Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation.

Shyu KG, Velusamy M, Hsia CW, Yang CH, Hsia CH, Chou DS, Jayakumar T, Sheu JR, Li JY.

Int J Mol Med. 2019 Jul;44(1):357. doi: 10.3892/ijmm.2019.4177. Epub 2019 Apr 30.


Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats.

Goodla L, Manubolu M, Pathakoti K, Jayakumar T, Sheu JR, Fraker M, Tchounwou PB, Poondamalli PR.

Int J Environ Res Public Health. 2019 Apr 23;16(8). pii: E1440. doi: 10.3390/ijerph16081440.


HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.

Sheu JR, Hsieh CY, Jayakumar T, Lin GY, Lee HN, Huang SW, Yang CH.

J Biomed Sci. 2019 Apr 18;26(1):27. doi: 10.1186/s12929-019-0521-1.


Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model.

Wu MP, Chang NC, Chung CL, Chiu WC, Hsu CC, Chen HM, Sheu JR, Jayakumar T, Chou DS, Fong TH.

Biomed Res Int. 2018 Nov 18;2018:5816875. doi: 10.1155/2018/5816875. eCollection 2018.


Structure⁻Activity Relationship Study of Newly Synthesized Iridium-III Complexes as Potential Series for Treating Thrombotic Diseases.

Yang CH, Hsia CW, Jayakumar T, Sheu JR, Hsia CH, Khamrang T, Chen YJ, Manubolu M, Chang Y.

Int J Mol Sci. 2018 Nov 19;19(11). pii: E3641. doi: 10.3390/ijms19113641.


Novel Therapeutic Agent against Platelet Activation In Vitro and Arterial Thrombosis In Vivo by Morin Hydrate.

Hsia CW, Wu MP, Velusamy M, Hsia CH, Chou DS, Tsai CL, Hsu CY, Jayakumar T, Chung CL, Sheu JR.

Int J Mol Sci. 2018 Aug 13;19(8). pii: E2386. doi: 10.3390/ijms19082386.


Possible Molecular Targets of Novel Ruthenium Complexes in Antiplatelet Therapy.

Jayakumar T, Hsu CY, Khamrang T, Hsia CH, Hsia CW, Manubolu M, Sheu JR.

Int J Mol Sci. 2018 Jun 20;19(6). pii: E1818. doi: 10.3390/ijms19061818. Review.


Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53.

Li JY, Liu CP, Shiao WC, Jayakumar T, Li YS, Chang NC, Huang SY, Hsieh CY.

Arch Med Sci. 2018 Apr;14(3):579-587. doi: 10.5114/aoms.2018.75085. Epub 2018 Apr 16.


Hinokitiol Inhibits Migration of A549 Lung Cancer Cells via Suppression of MMPs and Induction of Antioxidant Enzymes and Apoptosis.

Jayakumar T, Liu CH, Wu GY, Lee TY, Manubolu M, Hsieh CY, Yang CH, Sheu JR.

Int J Mol Sci. 2018 Mar 22;19(4). pii: E939. doi: 10.3390/ijms19040939.


Structure-Antiplatelet Activity Relationships of Novel Ruthenium (II) Complexes: Investigation of Its Molecular Targets.

Hsia CH, Jayakumar T, Sheu JR, Tsao SY, Velusamy M, Hsia CW, Chou DS, Chang CC, Chung CL, Khamrang T, Lin KC.

Molecules. 2018 Feb 22;23(2). pii: E477. doi: 10.3390/molecules23020477.


Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation.

Shyu KG, Velusamy M, Hsia CW, Yang CH, Hsia CH, Chou DS, Jayakumar T, Sheu JR, Li JY.

Int J Mol Med. 2018 May;41(5):2589-2600. doi: 10.3892/ijmm.2018.3472. Epub 2018 Feb 7. Erratum in: Int J Mol Med. 2019 Jul;44(1):357.


New Therapeutic Agent against Arterial Thrombosis: An Iridium(III)-Derived Organometallic Compound.

Hsia CW, Velusamy M, Tsao JT, Hsia CH, Chou DS, Jayakumar T, Lee LW, Li JY, Sheu JR.

Int J Mol Sci. 2017 Dec 5;18(12). pii: E2616. doi: 10.3390/ijms18122616.


Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition.

Chang Y, Li JY, Jayakumar T, Hung SH, Lee WC, Manubolu M, Sheu JR, Hsu MJ.

Int J Mol Sci. 2017 Nov 27;18(12). pii: E2545. doi: 10.3390/ijms18122545.


Mechanism of free radical generation in platelets and primary hepatocytes: A novel electron spin resonance study.

Wang CL, Yang PS, Tsao JT, Jayakumar T, Wang MJ, Sheu JR, Chou DS.

Mol Med Rep. 2018 Jan;17(1):2061-2069. doi: 10.3892/mmr.2017.8058. Epub 2017 Nov 14.


Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation.

Chang Y, Hsu WH, Yang WB, Jayakumar T, Lee TY, Sheu JR, Lu WJ, Li JY.

Int J Mol Med. 2017 Nov;40(5):1520-1528. doi: 10.3892/ijmm.2017.3133. Epub 2017 Sep 13.


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