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Items: 1 to 20 of 56


Structure and function of extracellular O-GlcNAc.

Ogawa M, Okajima T.

Curr Opin Struct Biol. 2019 Jan 19;56:72-77. doi: 10.1016/ [Epub ahead of print] Review.


Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice.

Bhuiyan RH, Ohmi Y, Ohkawa Y, Zhang P, Takano M, Hashimoto N, Okajima T, Furukawa K, Furukawa K.

Neuroscience. 2019 Jan 15;397:94-106. doi: 10.1016/j.neuroscience.2018.11.034. Epub 2018 Dec 4.


Congenital diseases caused by defective O-glycosylation of Notch receptors.

Tashima Y, Okajima T.

Nagoya J Med Sci. 2018 Aug;80(3):299-307. doi: 10.18999/nagjms.80.3.299. Review.


Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1.

Ogawa M, Senoo Y, Ikeda K, Takeuchi H, Okajima T.

Molecules. 2018 Jul 17;23(7). pii: E1745. doi: 10.3390/molecules23071745.


Notch signaling: A sweet strategy.

Okajima T.

Nat Chem Biol. 2017 Dec 12;14(1):3-4. doi: 10.1038/nchembio.2532. No abstract available.


O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals.

Sawaguchi S, Varshney S, Ogawa M, Sakaidani Y, Yagi H, Takeshita K, Murohara T, Kato K, Sundaram S, Stanley P, Okajima T.

Elife. 2017 Apr 11;6. pii: e24419. doi: 10.7554/eLife.24419.


[Corrigendum] Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.

Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K.

Int J Oncol. 2017 Feb;50(2):746. doi: 10.3892/ijo.2016.3796. Epub 2016 Dec 7.


Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing.

Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, Okajima T, Furukawa K.

Sci Rep. 2016 Sep 30;6:34505. doi: 10.1038/srep34505.


Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.

Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K.

Biochem Biophys Res Commun. 2016 Oct 21;479(3):453-460. doi: 10.1016/j.bbrc.2016.09.077. Epub 2016 Sep 16.


Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.

Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K.

Int J Oncol. 2016 Oct;49(4):1369-76. doi: 10.3892/ijo.2016.3638. Epub 2016 Jul 29.


Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells.

Kaneko K, Ohkawa Y, Hashimoto N, Ohmi Y, Kotani N, Honke K, Ogawa M, Okajima T, Furukawa K, Furukawa K.

J Biol Chem. 2016 Aug 5;291(32):16630-43. doi: 10.1074/jbc.M115.708834. Epub 2016 Jun 10.


Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes.

Bhuiyan RH, Kondo Y, Yamaguchi T, Tokuda N, Ohkawa Y, Hashimoto N, Ohmi Y, Yamauchi Y, Furukawa K, Okajima T, Furukawa K.

Glycobiology. 2016 Sep;26(9):984-998. Epub 2016 Apr 21.


Intracellular and extracellular O-linked N-acetylglucosamine in the nervous system.

Ogawa M, Sawaguchi S, Kamemura K, Okajima T.

Exp Neurol. 2015 Dec;274(Pt B):166-74. doi: 10.1016/j.expneurol.2015.08.009. Epub 2015 Aug 14. Review.


N-acetylglucosamine modification in the lumen of the endoplasmic reticulum.

Ogawa M, Sawaguchi S, Furukawa K, Okajima T.

Biochim Biophys Acta. 2015 Jun;1850(6):1319-24. doi: 10.1016/j.bbagen.2015.03.003. Epub 2015 Mar 17. Review.


Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.

Ogawa M, Sawaguchi S, Kawai T, Nadano D, Matsuda T, Yagi H, Kato K, Furukawa K, Okajima T.

J Biol Chem. 2015 Jan 23;290(4):2137-49. doi: 10.1074/jbc.M114.598821. Epub 2014 Dec 8.


O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation.

Ishio A, Sasamura T, Ayukawa T, Kuroda J, Ishikawa HO, Aoyama N, Matsumoto K, Gushiken T, Okajima T, Yamakawa T, Matsuno K.

J Biol Chem. 2015 Jan 2;290(1):505-19. doi: 10.1074/jbc.M114.616847. Epub 2014 Nov 5.


Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease.

Ogawa M, Furukawa K, Okajima T.

World J Biol Chem. 2014 May 26;5(2):224-30. doi: 10.4331/wjbc.v5.i2.224. Review.


GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody.

Ogawa M, Nakamura N, Nakayama Y, Kurosaka A, Manya H, Kanagawa M, Endo T, Furukawa K, Okajima T.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):88-93. doi: 10.1016/j.bbrc.2013.09.022. Epub 2013 Sep 13.


Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.

Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tsuchida A, Okajima T, Furukawa K, Urano T, Furukawa K.

J Biol Chem. 2013 Aug 16;288(33):24264-76. doi: 10.1074/jbc.M113.455006. Epub 2013 Jun 27.


Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding.

Hirano K, Hino S, Oshima K, Okajima T, Nadano D, Urisu A, Takaiwa F, Matsuda T.

J Biochem. 2013 Aug;154(2):195-205. doi: 10.1093/jb/mvt044. Epub 2013 May 20.


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