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Items: 14


The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention.

Sankaranarayanan R, Valiveti CK, Kumar DR, Van Slambrouck S, Kesharwani SS, Seefeldt T, Scaria J, Tummala H, Bhat GJ.

Cancers (Basel). 2019 Mar 26;11(3). pii: E427. doi: 10.3390/cancers11030427.


Interprofessional education in pharmacology using high-fidelity simulation.

Meyer BA, Seefeldt TM, Ngorsuraches S, Hendrickx LD, Lubeck PM, Farver DK, Heins JR.

Curr Pharm Teach Learn. 2017 Nov;9(6):1055-1062. doi: 10.1016/j.cptl.2017.07.015. Epub 2017 Sep 4.


Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer.

Dachineni R, Kumar DR, Callegari E, Kesharwani SS, Sankaranarayanan R, Seefeldt T, Tummala H, Bhat GJ.

Int J Oncol. 2017 Dec;51(6):1661-1673. doi: 10.3892/ijo.2017.4167. Epub 2017 Oct 19.


In Vitro and In Vivo Antimetastatic Effect of Glutathione Disulfide Liposomes.

Sadhu SS, Wang S, Dachineni R, Averineni RK, Seefeldt T, Xie J, Tummala H, Bhat GJ, Guan X.

Cancer Growth Metastasis. 2017 Mar 8;10:1179064417695255. doi: 10.1177/1179064417695255. eCollection 2017.


In-vitro and in-vivo inhibition of melanoma growth and metastasis by the drug combination of celecoxib and dacarbazine.

Sadhu SS, Wang S, Averineni RK, Seefeldt T, Yang Y, Guan X.

Melanoma Res. 2016 Dec;26(6):572-579.


Evaluation of a dithiocarbamate derivative as a model of thiol oxidative stress in H9c2 rat cardiomyocytes.

Xie J, Potter A, Xie W, Lynch C, Seefeldt T.

Free Radic Biol Med. 2014 May;70:214-22. doi: 10.1016/j.freeradbiomed.2014.02.022. Epub 2014 Mar 4.


Microtubule S-glutathionylation as a potential approach for antimitotic agents.

Chen W, Seefeldt T, Young A, Zhang X, Zhao Y, Ruffolo J, Kaushik RS, Guan X.

BMC Cancer. 2012 Jun 15;12:245. doi: 10.1186/1471-2407-12-245.


Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1.

Sadhu SS, Callegari E, Zhao Y, Guan X, Seefeldt T.

J Enzyme Inhib Med Chem. 2013 Jun;28(3):456-62. doi: 10.3109/14756366.2011.649267. Epub 2012 Feb 3.


Design, synthesis, and biological evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine and its analogs as a novel class of anticancer agents.

Chen W, Seefeldt T, Young A, Zhang X, Guan X.

Bioorg Med Chem. 2011 Jan 1;19(1):287-94. doi: 10.1016/j.bmc.2010.11.026. Epub 2010 Nov 13.


Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation.

Zhao Y, Seefeldt T, Chen W, Carlson L, Stoebner A, Hanson S, Foll R, Matthees DP, Palakurthi S, Guan X.

Free Radic Biol Med. 2009 Jul 15;47(2):176-83. doi: 10.1016/j.freeradbiomed.2009.04.022. Epub 2009 Apr 24.


Effects of glutathione reductase inhibition on cellular thiol redox state and related systems.

Zhao Y, Seefeldt T, Chen W, Wang X, Matthees D, Hu Y, Guan X.

Arch Biochem Biophys. 2009 May 1;485(1):56-62. doi: 10.1016/ Epub 2009 Mar 9.


Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione.

Seefeldt T, Zhao Y, Chen W, Raza AS, Carlson L, Herman J, Stoebner A, Hanson S, Foll R, Guan X.

J Biol Chem. 2009 Jan 30;284(5):2729-37. doi: 10.1074/jbc.M802683200. Epub 2008 Dec 2.


Determination of thiols and disulfides via HPLC quantification of 5-thio-2-nitrobenzoic acid.

Chen W, Zhao Y, Seefeldt T, Guan X.

J Pharm Biomed Anal. 2008 Dec 15;48(5):1375-80. doi: 10.1016/j.jpba.2008.08.033. Epub 2008 Sep 7.


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