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Items: 1 to 20 of 27

1.

Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis.

Lachiondo-Ortega S, Mercado-Gómez M, Serrano-Maciá M, Lopitz-Otsoa F, Salas-Villalobos TB, Varela-Rey M, Delgado TC, Martínez-Chantar ML.

Cells. 2019 Dec 4;8(12). pii: E1575. doi: 10.3390/cells8121575. Review.

2.

SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets.

Cannito S, Foglia B, Villano G, Turato C, Delgado TC, Morello E, Pin F, Novo E, Napione L, Quarta S, Ruvoletto M, Fasolato S, Zanus G, Colombatto S, Lopitz-Otsoa F, Fernández-Ramos D, Bussolino F, Sutti S, Albano E, Martínez-Chantar ML, Pontisso P, Parola M.

Cancers (Basel). 2019 Dec 4;11(12). pii: E1933. doi: 10.3390/cancers11121933.

3.

SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer.

Lopitz-Otsoa F, Delgado TC, Lachiondo-Ortega S, Azkargorta M, Elortza F, Rodríguez MS, Martínez-Chantar ML.

J Vis Exp. 2019 Nov 1;(153). doi: 10.3791/60098.

PMID:
31736480
4.

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.

Fernández-Tussy P, Fernández-Ramos D, Lopitz-Otsoa F, Simón J, Barbier-Torres L, Gomez-Santos B, Nuñez-Garcia M, Azkargorta M, Gutiérrez-de Juan V, Serrano-Macia M, Rodríguez-Agudo R, Iruzubieta P, Anguita J, Castro RE, Champagne D, Rincón M, Elortza F, Arslanow A, Krawczyk M, Lammert F, Kirchmeyer M, Behrmann I, Crespo J, Lu SC, Mato JM, Varela-Rey M, Aspichueta P, Delgado TC, Martínez-Chantar ML.

Mol Metab. 2019 Nov;29:40-54. doi: 10.1016/j.molmet.2019.08.008. Epub 2019 Aug 16.

5.

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer.

Zubiete-Franco I, García-Rodríguez JL, Lopitz-Otsoa F, Serrano-Macia M, Simon J, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gutiérrez-de-Juan V, López de Davalillo S, Carlevaris O, Beguiristain Gómez A, Villa E, Calvisi D, Martín C, Berra E, Aspichueta P, Beraza N, Varela-Rey M, Ávila M, Rodríguez MS, Mato JM, Díaz-Moreno I, Díaz-Quintana A, Delgado TC, Martínez-Chantar ML.

EBioMedicine. 2019 Feb;40:406-421. doi: 10.1016/j.ebiom.2018.12.031. Epub 2018 Dec 26.

6.

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.

Fernández-Ramos D, Fernández-Tussy P, Lopitz-Otsoa F, Gutiérrez-de-Juan V, Navasa N, Barbier-Torres L, Zubiete-Franco I, Simón J, Fernández AF, Arbelaiz A, Aransay AM, Lavín JL, Beraza N, Perugorria MJ, Banales JM, Villa E, Fraga MF, Anguita J, Avila MA, Berasain C, Iruzibieta P, Crespo J, Lu SC, Varela-Rey M, Mato JM, Delgado TC, Martínez-Chantar ML.

Cell Death Dis. 2018 Sep 20;9(10):958. doi: 10.1038/s41419-018-1014-y.

7.

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.

Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, Guitiérrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fernández-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hernández-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rincón M, Martínez-Chantar ML.

Nat Commun. 2017 Dec 12;8(1):2068. doi: 10.1038/s41467-017-01970-x.

8.

Role of Aramchol in steatohepatitis and fibrosis in mice.

Iruarrizaga-Lejarreta M, Varela-Rey M, Fernández-Ramos D, Martínez-Arranz I, Delgado TC, Simon J, Juan VG, delaCruz-Villar L, Azkargorta M, Lavin JL, Mayo R, Van Liempd SM, Aurrekoetxea I, Buqué X, Cave DD, Peña A, Rodríguez-Cuesta J, Aransay AM, Elortza F, Falcón-Pérez JM, Aspichueta P, Hayardeny L, Noureddin M, Sanyal AJ, Alonso C, Anguita J, Martínez-Chantar ML, Lu SC, Mato JM.

Hepatol Commun. 2017 Nov;1(9):911-927. doi: 10.1002/hep4.1107. Epub 2017 Oct 4.

9.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

10.

Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress.

Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R.

Nat Commun. 2017 Jun 16;8:16059. doi: 10.1038/ncomms16059.

11.

Hepatic p63 regulates steatosis via IKKβ/ER stress.

Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R.

Nat Commun. 2017 May 8;8:15111. doi: 10.1038/ncomms15111. Erratum in: Nat Commun. 2017 Jun 16;8:16059.

12.

Deregulated neddylation in liver fibrosis.

Zubiete-Franco I, Fernández-Tussy P, Barbier-Torres L, Simon J, Fernández-Ramos D, Lopitz-Otsoa F, Gutiérrez-de Juan V, de Davalillo SL, Duce AM, Iruzubieta P, Taibo D, Crespo J, Caballeria J, Villa E, Aurrekoetxea I, Aspichueta P, Varela-Rey M, Lu SC, Mato JM, Beraza N, Delgado TC, Martínez-Chantar ML.

Hepatology. 2017 Feb;65(2):694-709. doi: 10.1002/hep.28933. Epub 2016 Dec 30.

13.

An update on the use of benzoate, phenylacetate and phenylbutyrate ammonia scavengers for interrogating and modifying liver nitrogen metabolism and its implications in urea cycle disorders and liver disease.

De Las Heras J, Aldámiz-Echevarría L, Martínez-Chantar ML, Delgado TC.

Expert Opin Drug Metab Toxicol. 2017 Apr;13(4):439-448. doi: 10.1080/17425255.2017.1262843. Epub 2016 Nov 28. Review.

14.

Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia.

Martins FO, Delgado TC, Viegas J, Gaspar JM, Scott DK, O'Doherty RM, Macedo MP, Jones JG.

Br J Pharmacol. 2016 Jan;173(2):267-78. doi: 10.1111/bph.13362.

15.

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.

Barbier-Torres L, Beraza N, Fernández-Tussy P, Lopitz-Otsoa F, Fernández-Ramos D, Zubiete-Franco I, Varela-Rey M, Delgado TC, Gutiérrez V, Anguita J, Pares A, Banales JM, Villa E, Caballería J, Alvarez L, Lu SC, Mato JM, Martínez-Chantar ML.

Hepatology. 2015 Oct;62(4):1237-48. doi: 10.1002/hep.27959. Epub 2015 Jul 31.

16.

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.

Barbier-Torres L, Delgado TC, García-Rodríguez JL, Zubiete-Franco I, Fernández-Ramos D, Buqué X, Cano A, Gutiérrez-de Juan V, Fernández-Domínguez I, Lopitz-Otsoa F, Fernández-Tussy P, Boix L, Bruix J, Villa E, Castro A, Lu SC, Aspichueta P, Xirodimas D, Varela-Rey M, Mato JM, Beraza N, Martínez-Chantar ML.

Oncotarget. 2015 Feb 10;6(4):2509-23.

17.

Glutamate and GABA in Appetite Regulation.

Delgado TC.

Front Endocrinol (Lausanne). 2013 Aug 15;4:103. doi: 10.3389/fendo.2013.00103. eCollection 2013.

18.

²H enrichment distribution of hepatic glycogen from ²H₂O reveals the contribution of dietary fructose to glycogen synthesis.

Delgado TC, Martins FO, Carvalho F, Gonçalves A, Scott DK, O'Doherty R, Macedo MP, Jones JG.

Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E384-91. doi: 10.1152/ajpendo.00185.2012. Epub 2012 Dec 4.

19.

Effect of cyclosporine A on hepatic carbohydrate metabolism and hepatic gene expression in rat.

Delgado TC, Barosa C, Nunes PM, Scott DK, O'Doherty RM, Cerdán S, Geraldes CF, Jones JG.

Expert Opin Drug Metab Toxicol. 2012 Oct;8(10):1223-30. doi: 10.1517/17425255.2012.709500. Epub 2012 Aug 8.

PMID:
22870958
20.

Resolving the sources of plasma glucose excursions following a glucose tolerance test in the rat with deuterated water and [U-13C]glucose.

Delgado TC, Barosa C, Nunes PM, Cerdán S, Geraldes CF, Jones JG.

PLoS One. 2012;7(3):e34042. doi: 10.1371/journal.pone.0034042. Epub 2012 Mar 30.

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