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Items: 1 to 20 of 24

1.

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.

Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ekolle Ndode-Ekane X, Levonen AL, Pitkänen A.

Int J Mol Sci. 2019 Oct 29;20(21). pii: E5395. doi: 10.3390/ijms20215395.

2.

C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner.

Leskelä S, Huber N, Rostalski H, Natunen T, Remes AM, Takalo M, Hiltunen M, Haapasalo A.

Cells. 2019 Oct 10;8(10). pii: E1233. doi: 10.3390/cells8101233.

3.

L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia.

Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM.

Sci Rep. 2019 Sep 6;9(1):12860. doi: 10.1038/s41598-019-49009-z.

4.

Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway.

Gabbouj S, Ryhänen S, Marttinen M, Wittrahm R, Takalo M, Kemppainen S, Martiskainen H, Tanila H, Haapasalo A, Hiltunen M, Natunen T.

Front Neurosci. 2019 Jun 18;13:629. doi: 10.3389/fnins.2019.00629. eCollection 2019. Review.

5.

Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS.

Rostalski H, Leskelä S, Huber N, Katisko K, Cajanus A, Solje E, Marttinen M, Natunen T, Remes AM, Hiltunen M, Haapasalo A.

Front Neurosci. 2019 May 15;13:486. doi: 10.3389/fnins.2019.00486. eCollection 2019. Review.

6.

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease.

Marttinen M, Takalo M, Natunen T, Wittrahm R, Gabbouj S, Kemppainen S, Leinonen V, Tanila H, Haapasalo A, Hiltunen M.

Front Neurosci. 2018 Dec 14;12:963. doi: 10.3389/fnins.2018.00963. eCollection 2018. Review.

7.

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology.

Marttinen M, Paananen J, Neme A, Mitra V, Takalo M, Natunen T, Paldanius KMA, Mäkinen P, Bremang M, Kurki MI, Rauramaa T, Leinonen V, Soininen H, Haapasalo A, Pike I, Hiltunen M.

Neurobiol Dis. 2019 Apr;124:454-468. doi: 10.1016/j.nbd.2018.12.009. Epub 2018 Dec 15.

8.

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice.

Gabbouj S, Natunen T, Koivisto H, Jokivarsi K, Takalo M, Marttinen M, Wittrahm R, Kemppainen S, Naderi R, Posado-Fernández A, Ryhänen S, Mäkinen P, Paldanius KMA, Doria G, Poutiainen P, Flores O, Haapasalo A, Tanila H, Hiltunen M.

Neurobiol Aging. 2019 Mar;75:98-108. doi: 10.1016/j.neurobiolaging.2018.11.008. Epub 2018 Nov 17.

9.

Decreased plasma C-reactive protein levels in APOE ε4 allele carriers.

Martiskainen H, Takalo M, Solomon A, Stančáková A, Marttinen M, Natunen T, Haapasalo A, Herukka SK, Kuusisto J, Soininen H, Kivipelto M, Laakso M, Hiltunen M.

Ann Clin Transl Neurol. 2018 Sep 17;5(10):1229-1240. doi: 10.1002/acn3.639. eCollection 2018 Oct.

10.

Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target.

Natunen TA, Gynther M, Rostalski H, Jaako K, Jalkanen AJ.

Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):40-49. doi: 10.1111/bcpt.13094. Epub 2018 Aug 14.

PMID:
29998529
11.

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M.

J Neuroinflammation. 2017 Nov 7;14(1):215. doi: 10.1186/s12974-017-0991-6.

12.

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy.

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatillo O, Sallinen J, Ndode-Ekane XE, Pitkänen A.

Epilepsy Res. 2017 Oct;136:18-34. doi: 10.1016/j.eplepsyres.2017.07.005. Epub 2017 Jul 12.

PMID:
28753497
13.

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.

Kurkinen KM, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, Sarajärvi T, Gabbouj S, Kurki M, Paananen J, Koivisto AM, Rauramaa T, Leinonen V, Tanila H, Soininen H, Lucas FR, Haapasalo A, Hiltunen M.

J Cell Sci. 2016 Jun 1;129(11):2224-38. doi: 10.1242/jcs.185215. Epub 2016 Apr 15.

14.

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.

Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M.

Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10.

PMID:
26563932
15.

Genetic Variation in δ-Opioid Receptor Associates with Increased β- and γ-Secretase Activity in the Late Stages of Alzheimer's Disease.

Sarajärvi T, Marttinen M, Natunen T, Kauppinen T, Mäkinen P, Helisalmi S, Laitinen M, Rauramaa T, Leinonen V, Petäjä-Repo U, Soininen H, Haapasalo A, Hiltunen M.

J Alzheimers Dis. 2015;48(2):507-16. doi: 10.3233/JAD-150221.

PMID:
26402014
16.

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models.

Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M.

Neurobiol Aging. 2015 Feb;36(2):1221.e15-28. doi: 10.1016/j.neurobiolaging.2014.09.003. Epub 2014 Sep 6.

PMID:
25281018
17.

Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.

Martiskainen H, Helisalmi S, Viswanathan J, Kurki M, Hall A, Herukka SK, Sarajärvi T, Natunen T, Kurkinen KM, Huovinen J, Mäkinen P, Laitinen M, Koivisto AM, Mattila KM, Lehtimäki T, Remes AM, Leinonen V, Haapasalo A, Soininen H, Hiltunen M.

J Alzheimers Dis. 2015;43(2):565-73. doi: 10.3233/JAD-140777.

PMID:
25096612
18.

Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease.

Natunen T, Martiskainen H, Sarajärvi T, Helisalmi S, Pursiheimo JP, Viswanathan J, Laitinen M, Mäkinen P, Kauppinen T, Rauramaa T, Leinonen V, Alafuzoff I, Haapasalo A, Soininen H, Hiltunen M.

PLoS One. 2013 Nov 20;8(11):e80700. doi: 10.1371/journal.pone.0080700. eCollection 2013.

19.

Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.

Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M.

J Alzheimers Dis. 2013;37(1):217-32. doi: 10.3233/JAD-130104.

PMID:
23970038
20.

Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells.

Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M.

Biochemistry. 2013 Jun 4;52(22):3899-912. doi: 10.1021/bi400138p. Epub 2013 May 21.

PMID:
23663107

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