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Modifications of expression of genes and proteins involved in DNA repair and nitric oxide metabolism by carbatonides [disodium-2,6-dimethyl-1,4-dihydropyridine- 3,5-bis(carbonyloxyacetate) derivatives] in intact and diabetic rats.

Ošiņa K, Leonova E, Isajevs S, Baumane L, Rostoka E, Sjakste T, Bisenieks E, Duburs G, Vīgante B, Sjakste N.

Arh Hig Rada Toksikol. 2017 Sep 26;68(3):212-227. doi: 10.1515/aiht-2017-68-2945.


Effects of an Antimutagenic 1,4-Dihydropyridine AV-153 on Expression of Nitric Oxide Synthases and DNA Repair-related Enzymes and Genes in Kidneys of Rats with a Streptozotocin Model of Diabetes Mellitus.

Ošiņa K, Rostoka E, Isajevs S, Sokolovska J, Sjakste T, Sjakste N.

Basic Clin Pharmacol Toxicol. 2016 Nov;119(5):458-463. doi: 10.1111/bcpt.12617. Epub 2016 May 30.


New 1,4-Dihydropyridines Down-regulate Nitric Oxide in Animals with Streptozotocin-induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action.

Leonova E, Sokolovska J, Boucher JL, Isajevs S, Rostoka E, Baumane L, Sjakste T, Sjakste N.

Basic Clin Pharmacol Toxicol. 2016 Jul;119(1):19-31. doi: 10.1111/bcpt.12542. Epub 2016 Jan 25.


Genetic variations in the PSMA3, PSMA6 and PSMC6 genes are associated with type 1 diabetes in Latvians and with expression level of number of UPS-related and T1DM-susceptible genes in HapMap individuals.

Sjakste T, Paramonova N, Osina K, Dokane K, Sokolovska J, Sjakste N.

Mol Genet Genomics. 2016 Apr;291(2):891-903. doi: 10.1007/s00438-015-1153-0. Epub 2015 Dec 12.


1,4-Dihydropyridine derivatives without Ca2+-antagonist activity up-regulate Psma6 mRNA expression in kidneys of intact and diabetic rats.

Ošiņa K, Rostoka E, Sokolovska J, Paramonova N, Bisenieks E, Duburs G, Sjakste N, Sjakste T.

Cell Biochem Funct. 2016 Jan;34(1):3-6. doi: 10.1002/cbf.3160. Epub 2015 Dec 4.


Changes in glucose transporter expression and nitric oxide production are associated with liver injury in diabetes.

Sokolovska J, Isajevs S, Rostoka E, Sjakste T, Trapiņa I, Ošiņa K, Paramonova N, Sjakste N.

Cell Biochem Funct. 2015 Aug;33(6):367-74. doi: 10.1002/cbf.3123. Epub 2015 Sep 7.


PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese.

Sjakste T, Paramonova N, Wu LS, Zemeckiene Z, Sitkauskiene B, Sakalauskas R, Wang JY, Sjakste N.

Meta Gene. 2014 Apr 17;2:283-98. doi: 10.1016/j.mgene.2014.03.002. eCollection 2014 Dec.


Evaluation of proteasomal gene polymorphisms in Lithuanian patients with asthma.

Zemeckiene Z, Sitkauskiene B, Gasiuniene E, Paramonova N, Tamasauskiene L, Vitkauskiene A, Sjakste T, Sakalauskas R.

J Asthma. 2015 Jun;52(5):447-52. doi: 10.3109/02770903.2014.982761. Epub 2014 Nov 21.


Juvenile idiopathic arthritis subtype- and sex-specific associations with genetic variants in the PSMA6/PSMC6/PSMA3 gene cluster.

Sjakste T, Paramonova N, Rumba-Rozenfelde I, Trapina I, Sugoka O, Sjakste N.

Pediatr Neonatol. 2014 Oct;55(5):393-403. doi: 10.1016/j.pedneo.2014.01.007. Epub 2014 May 27.


Association of obesity with proteasomal gene polymorphisms in children.

Kupca S, Sjakste T, Paramonova N, Sugoka O, Rinkuza I, Trapina I, Daugule I, Sipols AJ, Rumba-Rozenfelde I.

J Obes. 2013;2013:638154. doi: 10.1155/2013/638154. Epub 2013 Dec 21.


Proteasomes and proteasomal gene polymorphism in association with inflammation and various diseases.

Zemeckienė Z, Vitkauskienė A, Sjakste T, Sitkauskienė B, Sakalauskas R.

Medicina (Kaunas). 2013;49(5):207-13. Review.


Comparison of the effects of glibenclamide on metabolic parameters, GLUT1 expression, and liver injury in rats with severe and mild streptozotocin-induced diabetes mellitus.

Sokolovska J, Isajevs S, Sugoka O, Sharipova J, Paramonova N, Isajeva D, Rostoka E, Sjakste T, Kalvinsh I, Sjakste N.

Medicina (Kaunas). 2012;48(10):532-43.


Functional significance of microsatellite markers.

Sjakste T, Paramonova N, Sjakste N.

Medicina (Kaunas). 2013;49(12):505-9. Review.


The burden of allergic asthma in children: a landscape comparison based on data from Lithuanian, Latvian, and Taiwanese populations.

Wu LS, Sjakste T, Sakalauskas R, Sitkauskiene B, Paramonova N, Gasiuniene E, Jan RL, Wang JY.

Pediatr Neonatol. 2012 Oct;53(5):276-82. doi: 10.1016/j.pedneo.2012.08.001. Epub 2012 Sep 14. Review.


Analysis of the single-nucleotide polymorphism in the 5'UTR and part of intron I of the sheep MSTN gene.

Sjakste T, Paramonova N, Grislis Z, Trapina I, Kairisa D.

DNA Cell Biol. 2011 Jul;30(7):433-44. doi: 10.1089/dna.2010.1153. Epub 2011 Feb 16.


Correction of glycaemia and GLUT1 level by mildronate in rat streptozotocin diabetes mellitus model.

Sokolovska J, Isajevs S, Sugoka O, Sharipova J, Lauberte L, Svirina D, Rostoka E, Sjakste T, Kalvinsh I, Sjakste N.

Cell Biochem Funct. 2011 Jan-Feb;29(1):55-63. doi: 10.1002/cbf.1719.


Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes mellitus model.

Sokolovska J, Isajevs S, Sugoka O, Sharipova J, Lauberte L, Svirina D, Rostoka E, Sjakste T, Kalvinsh I, Sjakste N.

Arch Physiol Biochem. 2010 Jul;116(3):137-45. doi: 10.3109/13813455.2010.494672.


Identification of a novel candidate locus for juvenile idiopathic arthritis at 14q13.2 in the Latvian population by association analysis with microsatellite markers.

Sjakste T, Trapina I, Rumba-Rozenfelde I, Lunin R, Sugoka O, Sjakste N.

DNA Cell Biol. 2010 Sep;29(9):543-51. doi: 10.1089/dna.2009.0970.


Development-dependent changes in the tight DNA-protein complexes of barley on chromosome and gene level.

Sjakste T, Bielskiene K, Röder M, Sugoka O, Labeikyte D, Bagdoniene L, Juodka B, Vassetzky Y, Sjakste N.

BMC Plant Biol. 2009 May 12;9:56. doi: 10.1186/1471-2229-9-56.


Transcription- and apoptosis-dependent long-range distribution of tight DNA-protein complexes in the chicken alpha-globin gene.

Bielskiene K, Bagdoniene L, Juodka B, Lipinski M, Sjakste T, Vassetzky YS, Sjakste N.

DNA Cell Biol. 2008 Nov;27(11):615-21. doi: 10.1089/dna.2008.0771.


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