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Items: 1 to 20 of 38


Primary cilia and their role in cancer.

Higgins M, Obaidi I, McMorrow T.

Oncol Lett. 2019 Mar;17(3):3041-3047. doi: 10.3892/ol.2019.9942. Epub 2019 Jan 17. Review.


The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells.

Sumayao R Jr, Newsholme P, McMorrow T.

Antioxidants (Basel). 2018 Dec 3;7(12). pii: E179. doi: 10.3390/antiox7120179. Review.


Inducible nitric oxide synthase inhibitor 1400W increases Na+ ,K+ -ATPase levels and activity and ameliorates mitochondrial dysfunction in Ctns null kidney proximal tubular epithelial cells.

Sumayao R Jr, Newsholme P, McMorrow T.

Clin Exp Pharmacol Physiol. 2018 Nov;45(11):1149-1160. doi: 10.1111/1440-1681.12998. Epub 2018 Jul 30.


Identification of the Multifaceted Chemopreventive Activity of Curcumin Against the Carcinogenic Potential of the Food Additive, KBrO3.

Obaidi I, Higgins M, Bahar B, Davis JL, McMorrow T.

Curr Pharm Des. 2018;24(5):595-614. doi: 10.2174/1381612824666171226143201.


Tacrolimus Modulates TGF-β Signaling to Induce Epithelial-Mesenchymal Transition in Human Renal Proximal Tubule Epithelial Cells.

Bennett J, Cassidy H, Slattery C, Ryan MP, McMorrow T.

J Clin Med. 2016 Apr 26;5(5). pii: E50. doi: 10.3390/jcm5050050.


Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells.

Sumayao R, McEvoy B, Newsholme P, McMorrow T.

J Physiol. 2016 Jun 15;594(12):3353-70. doi: 10.1113/JP271858. Epub 2016 Apr 10.


Cystine accumulation attenuates insulin release from the pancreatic β-cell due to elevated oxidative stress and decreased ATP levels.

McEvoy B, Sumayao R, Slattery C, McMorrow T, Newsholme P.

J Physiol. 2015 Dec 1;593(23):5167-82. doi: 10.1113/JP271237. Epub 2015 Nov 18.


New developments concerning the proximal tubule in diabetic nephropathy: in vitro models and mechanisms.

Slyne J, Slattery C, McMorrow T, Ryan MP.

Nephrol Dial Transplant. 2015 Aug;30 Suppl 4:iv60-7. doi: 10.1093/ndt/gfv264. Review.


Urinary biomarkers of chronic allograft nephropathy.

Cassidy H, Slyne J, O'Kelly P, Traynor C, Conlon PJ, Johnston O, Slattery C, Ryan MP, McMorrow T.

Proteomics Clin Appl. 2015 Jun;9(5-6):574-85. doi: 10.1002/prca.201400200.


Mechanisms of chemical carcinogenesis in the kidneys.

Radford R, Frain H, Ryan MP, Slattery C, McMorrow T.

Int J Mol Sci. 2013 Sep 25;14(10):19416-33. doi: 10.3390/ijms141019416. Review.


High-Throughput Proteomic Approaches to the Elucidation of Potential Biomarkers of Chronic Allograft Injury (CAI).

Cassidy H, Slyne J, Frain H, Slattery C, Ryan MP, McMorrow T.

Proteomes. 2013 Sep 23;1(2):159-179. doi: 10.3390/proteomes1020159. Review.


Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line.

Sumayao R, McEvoy B, Martin-Martin N, McMorrow T, Newsholme P.

Exp Physiol. 2013 Oct;98(10):1505-17. doi: 10.1113/expphysiol.2013.073809. Epub 2013 Jun 28.


Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells.

Limonciel A, Wilmes A, Aschauer L, Radford R, Bloch KM, McMorrow T, Pfaller W, van Delft JH, Slattery C, Ryan MP, Lock EA, Jennings P.

Arch Toxicol. 2012 Nov;86(11):1741-51. doi: 10.1007/s00204-012-0897-0. Epub 2012 Jul 4.


The role of MAPK in drug-induced kidney injury.

Cassidy H, Radford R, Slyne J, O'Connell S, Slattery C, Ryan MP, McMorrow T.

J Signal Transduct. 2012;2012:463617. doi: 10.1155/2012/463617. Epub 2012 Mar 12.


Sirolimus enhances cyclosporine a-induced cytotoxicity in human renal glomerular mesangial cells.

O'Connell S, Slattery C, Ryan MP, McMorrow T.

J Transplant. 2012;2012:980910. doi: 10.1155/2012/980910. Epub 2012 Jan 23.


Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle.

Radford R, Slattery C, Jennings P, Blacque O, Pfaller W, Gmuender H, Van Delft J, Ryan MP, McMorrow T.

Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F905-16. doi: 10.1152/ajprenal.00427.2011. Epub 2012 Jan 18. Erratum in: Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F796. Blaque, Oliver [corrected to Blacque, Oliver].


Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling.

O'Connell S, Tuite N, Slattery C, Ryan MP, McMorrow T.

Toxicol Sci. 2012 Mar;126(1):101-13. doi: 10.1093/toxsci/kfr330. Epub 2011 Dec 6.


Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model.

Jennings P, Weiland C, Limonciel A, Bloch KM, Radford R, Aschauer L, McMorrow T, Wilmes A, Pfaller W, Ahr HJ, Slattery C, Lock EA, Ryan MP, Ellinger-Ziegelbauer H.

Arch Toxicol. 2012 Apr;86(4):571-89. doi: 10.1007/s00204-011-0780-4. Epub 2011 Nov 29.


RhoA and Rho kinase mediate cyclosporine A and sirolimus-induced barrier tightening in renal proximal tubular cells.

Martin-Martin N, Dan Q, Amoozadeh Y, Waheed F, McMorrow T, Ryan MP, Szászi K.

Int J Biochem Cell Biol. 2012 Jan;44(1):178-88. doi: 10.1016/j.biocel.2011.10.014. Epub 2011 Nov 2.


TGF-β1 mediates sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway.

Martin-Martin N, Slattery C, McMorrow T, Ryan MP.

Am J Physiol Renal Physiol. 2011 Dec;301(6):F1281-92. doi: 10.1152/ajprenal.00188.2010. Epub 2011 Aug 31.

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