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Items: 1 to 20 of 107

1.

Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.

Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA.

Structure. 2019 May 14. pii: S0969-2126(19)30161-3. doi: 10.1016/j.str.2019.04.016. [Epub ahead of print]

PMID:
31178222
2.

Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design.

Irsheid L, Wehler T, Borek C, Kiefer W, Brenk R, Ortiz-Soto ME, Seibel J, Schirmeister T.

PLoS One. 2019 May 8;14(5):e0216132. doi: 10.1371/journal.pone.0216132. eCollection 2019.

3.

Evaluation of curcumin irreversibility.

Ettari R, Previti S, Maiorana S, Allegra A, Schirmeister T, Grasso S, Zappalà M.

Nat Prod Res. 2019 Jan 24:1-4. doi: 10.1080/14786419.2018.1557658. [Epub ahead of print] No abstract available.

PMID:
30676764
4.

Natural Product Repertoire of the Genus Amphimedon.

Shady NH, Fouad MA, Salah Kamel M, Schirmeister T, Abdelmohsen UR.

Mar Drugs. 2018 Dec 30;17(1). pii: E19. doi: 10.3390/md17010019. Review.

5.

Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates.

Royo S, Schirmeister T, Kaiser M, Jung S, Rodríguez S, Bautista JM, González FV.

Bioorg Med Chem. 2018 Sep 1;26(16):4624-4634. doi: 10.1016/j.bmc.2018.07.015. Epub 2018 Jul 10.

PMID:
30037754
6.

New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8.

Fey P, Chartomatsidou R, Kiefer W, Mottram JC, Kersten C, Schirmeister T.

Eur J Med Chem. 2018 Aug 5;156:587-597. doi: 10.1016/j.ejmech.2018.07.012. Epub 2018 Jul 9.

PMID:
30029081
7.

Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense.

Ettari R, Previti S, Maiorana S, Allegra A, Schirmeister T, Grasso S, Zappalà M.

Nat Prod Res. 2018 Jun 13:1-5. doi: 10.1080/14786419.2018.1483927. [Epub ahead of print]

PMID:
29897253
8.

Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis.

De Luca L, Ferro S, Buemi MR, Monforte AM, Gitto R, Schirmeister T, Maes L, Rescifina A, Micale N.

Chem Biol Drug Des. 2018 Sep;92(3):1585-1596. doi: 10.1111/cbdd.13326. Epub 2018 May 31.

PMID:
29729080
9.

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.

Giroud M, Kuhn B, Saint-Auret S, Kuratli C, Martin RE, Schuler F, Diederich F, Kaiser M, Brun R, Schirmeister T, Haap W.

J Med Chem. 2018 Apr 26;61(8):3370-3388. doi: 10.1021/acs.jmedchem.7b01870. Epub 2018 Apr 6.

PMID:
29590751
10.

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W.

J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13.

PMID:
29590750
11.

Structure-Function Evaluation of Imidazopyridine Derivatives Selective for δ-Subunit-Containing γ-Aminobutyric Acid Type A (GABAA) Receptors.

Yakoub K, Jung S, Sattler C, Damerow H, Weber J, Kretzschmann A, Cankaya AS, Piel M, Rösch F, Haugaard AS, Frølund B, Schirmeister T, Lüddens H.

J Med Chem. 2018 Mar 8;61(5):1951-1968. doi: 10.1021/acs.jmedchem.7b01484. Epub 2018 Feb 26.

PMID:
29451785
12.

Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE.

Scala A, Rescifina A, Micale N, Piperno A, Schirmeister T, Maes L, Grassi G.

Chem Biol Drug Des. 2018 Feb;91(2):597-604. doi: 10.1111/cbdd.13124. Epub 2017 Nov 10.

PMID:
29045053
13.

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M.

J Med Chem. 2017 Aug 24;60(16):6911-6923. doi: 10.1021/acs.jmedchem.7b00405. Epub 2017 Aug 11.

PMID:
28763614
14.

Bistacrines as potential antitrypanosomal agents.

Schmidt I, Göllner S, Fuß A, Stich A, Kucharski A, Schirmeister T, Katzowitsch E, Bruhn H, Miliu A, Krauth-Siegel RL, Holzgrabe U.

Bioorg Med Chem. 2017 Aug 15;25(16):4526-4531. doi: 10.1016/j.bmc.2017.06.051. Epub 2017 Jul 1.

PMID:
28698054
15.

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.

Kuhn B, Tichý M, Wang L, Robinson S, Martin RE, Kuglstatter A, Benz J, Giroud M, Schirmeister T, Abel R, Diederich F, Hert J.

J Med Chem. 2017 Mar 23;60(6):2485-2497. doi: 10.1021/acs.jmedchem.6b01881. Epub 2017 Mar 13.

PMID:
28287264
16.

Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents.

Massai L, Messori L, Micale N, Schirmeister T, Maes L, Fregona D, Cinellu MA, Gabbiani C.

Biometals. 2017 Apr;30(2):313-320. doi: 10.1007/s10534-017-0007-0. Epub 2017 Mar 10.

PMID:
28283781
17.

Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation.

Schirmeister T, Oli S, Wu H, Della Sala G, Costantino V, Seo EJ, Efferth T.

Mar Drugs. 2017 Mar 3;15(3). pii: E63. doi: 10.3390/md15030063.

18.

Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain.

Latorre A, Schirmeister T, Kesselring J, Jung S, Johé P, Hellmich UA, Heilos A, Engels B, Krauth-Siegel RL, Dirdjaja N, Bou-Iserte L, Rodríguez S, González FV.

ACS Med Chem Lett. 2016 Sep 21;7(12):1073-1076. eCollection 2016 Dec 8.

19.

Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide⋅⋅⋅Heteroarene π-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.

Giroud M, Ivkovic J, Martignoni M, Fleuti M, Trapp N, Haap W, Kuglstatter A, Benz J, Kuhn B, Schirmeister T, Diederich F.

ChemMedChem. 2017 Feb 3;12(3):257-270. doi: 10.1002/cmdc.201600563. Epub 2017 Jan 12.

PMID:
27992115
20.

Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei.

Schirmeister T, Schmitz J, Jung S, Schmenger T, Krauth-Siegel RL, Gütschow M.

Bioorg Med Chem Lett. 2017 Jan 1;27(1):45-50. doi: 10.1016/j.bmcl.2016.11.036. Epub 2016 Nov 15.

PMID:
27890381

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