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Molecules. 2011 Jun 27;16(7):5387-401. doi: 10.3390/molecules16075387.

Enantioselective addition of allyltin reagents to amino aldehydes catalyzed with bis(oxazolinyl)phenylrhodium(III) aqua complexes.

Author information

1
Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580, Japan. motoyama@cm.kyushu-u.ac.jp

Abstract

Bis(oxazolinyl)phenylrhodium(III) aqua complexes, (Phebox)RhX₂(H₂O) [X = Cl, Br], were found to be efficient Lewis acid catalysts for the enantioselective addition of allyl- and methallyltributyltin reagents to amino aldehydes. The reactions proceed smoothly in the presence of 5-10 mol % of (Phebox)RhX₂(H₂O) complex at ambient temperature to give the corresponding amino alcohols with modest to good enantioselectivity (up to 94% ee).

PMID:
21709621
PMCID:
PMC6264686
DOI:
10.3390/molecules16075387
[Indexed for MEDLINE]
Free PMC Article

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