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Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.

Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear NJ, Ramanathan S, Sharma A, León F, Hiranita T, Avery BA, McMahon LR, McCurdy CR.

J Med Chem. 2020 Jan 9;63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. Epub 2019 Dec 27.


The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats.

Hiranita T, Leon F, Felix JS, Restrepo LF, Reeves ME, Pennington AE, Obeng S, Avery BA, McCurdy CR, McMahon LR, Wilkerson JL.

Psychopharmacology (Berl). 2019 Sep;236(9):2725-2734. doi: 10.1007/s00213-019-05247-7. Epub 2019 May 17.


Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects.

Hong WC, Wasko MJ, Wilkinson DS, Hiranita T, Li L, Hayashi S, Snell DB, Madura JD, Surratt CK, Katz JL.

J Pharmacol Exp Ther. 2018 Sep;366(3):527-540. doi: 10.1124/jpet.118.250498. Epub 2018 Jun 26.


Positron emission tomography (PET) imaging of nicotine-induced dopamine release in squirrel monkeys using [18F]Fallypride.

Naylor JE, Hiranita T, Matazel KS, Zhang X, Paule MG, Goodwin AK.

Drug Alcohol Depend. 2017 Oct 1;179:254-259. doi: 10.1016/j.drugalcdep.2017.07.013. Epub 2017 Aug 8.


The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.

Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL.

J Biol Chem. 2017 Jul 7;292(27):11250-11261. doi: 10.1074/jbc.M116.774075. Epub 2017 May 11.


σ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration.

Hiranita T, Hong WC, Kopajtic T, Katz JL.

J Pharmacol Exp Ther. 2017 Jul;362(1):2-13. doi: 10.1124/jpet.117.241109. Epub 2017 Apr 25.


Importance of Substrate-Coupled Proton Antiport by the Vesicular Monoamine Transporter in the Actions of Amphetamines in Drosophila Brain.

Hiranita T, Freyberg Z.

J Alcohol Drug Depend. 2016 Dec;4(6). pii: e136. doi: 10.4172/2329-6488.1000e136. Epub 2016 Dec 16. No abstract available.


A Role for Sigma Receptors in Stimulant Self-Administration and Addiction.

Katz JL, Hiranita T, Hong WC, Job MO, McCurdy CR.

Handb Exp Pharmacol. 2017;244:177-218. doi: 10.1007/164_2016_94. Review.


Lack of Effects of Toll-Like Receptor 4 Antagonists on the Reinforcing Effects of Cocaine and Remifentanil.

Hiranita T.

J Alcohol Drug Depend. 2016 Dec;4(6). pii: 1000e135. doi: 10.4172/2329-6488. No abstract available.


DAT Conformation Does Not Predict the Ability of Atypical Dopamine Uptake Inhibitors to Substitute for Cocaine.

Hiranita T.

J Alcohol Drug Depend. 2016;4(4). pii: e132. Epub 2016 Aug 8. No abstract available.


Identification of Antagonists Selective for Sigma Receptor Subtypes that are Active In vivo.

Hiranita T.

J Alcohol Drug Depend. 2016;4(4). pii: e131. Epub 2016 Jul 11. No abstract available.


Identification of the Sigma-2 Receptor: Distinct from the Progesterone Receptor Membrane Component 1 (PGRMC1).

Hiranita T.

J Alcohol Drug Depend. 2016;4. pii: doi:10.4172/2329-6488.1000e130. Epub 2016 Apr 25. No abstract available.


(-)-Trans-Δ9-Tetrahydrocannabinol-Like Discriminative-Stimulus Effects of Gabapentin in Cannabis Users.

Hiranita T.

J Alcohol Drug Depend. 2016 Feb;4(1). pii: e129. Epub 2016 Feb 10. No abstract available.


Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids.

Tanda G, Mereu M, Hiranita T, Quarterman JC, Coggiano M, Katz JL.

Neuropsychopharmacology. 2016 Oct;41(11):2772-81. doi: 10.1038/npp.2016.91. Epub 2016 Jun 14.


Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.

Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR.

J Pharmacol Exp Ther. 2016 Jul;358(1):109-24. doi: 10.1124/jpet.116.232728. Epub 2016 Apr 21.


Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.

Freyberg Z, Sonders MS, Aguilar JI, Hiranita T, Karam CS, Flores J, Pizzo AB, Zhang Y, Farino ZJ, Chen A, Martin CA, Kopajtic TA, Fei H, Hu G, Lin YY, Mosharov EV, McCabe BD, Freyberg R, Wimalasena K, Hsin LW, Sames D, Krantz DE, Katz JL, Sulzer D, Javitch JA.

Nat Commun. 2016 Feb 16;7:10652. doi: 10.1038/ncomms10652.


A role for sigma receptors in stimulant self-administration and addiction.

Katz JL, Hong WC, Hiranita T, Su TP.

Behav Pharmacol. 2016 Apr;27(2-3 Spec Issue):100-15. doi: 10.1097/FBP.0000000000000209. Review.


Dopamine D₂-Like Receptors and Behavioral Economics of Food Reinforcement.

Soto PL, Hiranita T, Xu M, Hursh SR, Grandy DK, Katz JL.

Neuropsychopharmacology. 2016 Mar;41(4):971-8. doi: 10.1038/npp.2015.223. Epub 2015 Jul 24.


In Vivo Significance of In Vitro Studies on G-Protein-Coupled Receptor Heteromers.

Hiranita T.

J Alcohol Drug Depend. 2015 Apr;3(2). pii: e120. Epub 2015 Mar 14. No abstract available.


The Reinforcing Effects of Nicotine in Humans and Nonhuman Primates: A Review of Intravenous Self-Administration Evidence and Future Directions for Research.

Goodwin AK, Hiranita T, Paule MG.

Nicotine Tob Res. 2015 Nov;17(11):1297-310. doi: 10.1093/ntr/ntv002. Epub 2015 Feb 10. Review.


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